TGF-β Regulates Reciprocal Differentiation of CD4 + CD25 + Foxp3 + Regulatory T Cells and IL-17-Producing Th17 Cells from Naïve CD4 + CD25 – T Cells

2008 ◽  
pp. 111-134
Author(s):  
Wanjun Chen
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Th17 Cells

scholarly journals Control of the differentiation of regulatory T cells and TH17 cells by the DNA-binding inhibitor Id3

2010 ◽  
Vol 12 (1) ◽  
pp. 86-95 ◽  
Author(s):  
Takashi Maruyama ◽  
Jun Li ◽  
Jose P Vaque ◽  
Joanne E Konkel ◽  
Weifeng Wang ◽  
...  
Keyword(s):  
T Cells ◽  
Dna Binding ◽  
Regulatory T Cells ◽  
Th17 Cells

scholarly journals Recovery from acute lung injury can be regulated via modulation of regulatory T cells and Th17 cells

2018 ◽  
Vol 88 (5) ◽  
pp. e12715 ◽  
Author(s):  
Linlin Wang ◽  
Xiaocen Wang ◽  
Lin Tong ◽  
Jian Wang ◽  
Maosen Dou ◽  
...  
Keyword(s):  
T Cells ◽  
Acute Lung Injury ◽  
Regulatory T Cells ◽  
Lung Injury ◽  
Th17 Cells

CARDIAC REJECTION IS A TH1 MEDIATED RESPONSE CONTROLLED BY DONOR SPECIFIC REGULATORY T CELLS: NO ROLE FOR TH17 CELLS

2010 ◽  
Vol 90 ◽  
pp. 263
Author(s):  
C. Baan ◽  
A. Peeters ◽  
A. H.M.M. Balk ◽  
E. Dijke ◽  
W. Weimar
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Th17 Cells ◽  
Cardiac Rejection

scholarly journals Notch signaling pathway regulates CD4+CD25+CD127dim/− regulatory T cells and T helper 17 cells function in gastric cancer patients

2019 ◽  
Vol 39 (5) ◽  
Author(s):  
Lu Yang ◽  
Ke-Lei Zhao ◽  
Lei Qin ◽  
Dan-Xia Ji ◽  
Bin Zhang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
T Cells ◽  
Regulatory T Cells ◽  
Notch Signaling ◽  
Cancer Progression ◽  
Th17 Cells ◽  
Cellular Proliferation ◽  
Current Data ◽  
T Helper ◽  
T Helper 17

Abstract Regulatory T cells (Tregs) and T helper 17 (Th17) cells contribute to cancer progression and prognosis. However, regulatory factors associated with Tregs–Th17 balance were not completely understood. We previously demonstrated an immune-modulatory capacity by Notch signaling inactivation to reverse Tregs–Th17 disequilibrium in chronic hepatitis C. Thus, the aim of current study was to assess the role of Notch signaling in modulation Tregs and Th17 cells function in gastric cancer (GC) patients. A total of 51 GC patients and 18 normal controls (NCs) were enrolled. Notch1 and Notch2 mRNA expressions were semiquantified by real-time polymerase chain reaction. Tregs/Th17 percentages, transcriptional factors, and cytokines production were investigated in response to the stimulation of Notch signaling inhibitor DAPT. Both Notch1 and Notch2 mRNA expressions were elevated in GC tissues and peripheral bloods in GC patients. CD4+CD25+CD127dim/− Tregs and Th17 cells percentage was also elevated in GC patients compared with in NCs. DAPT treatment did not affect frequency of either circulating Tregs or Th17 cells, however, reduced FoxP3/RORγt mRNA expression and interleukin (IL)-35/IL-17 production in purified CD4+ T cells from GC patients. Moreover, blockade of Notch signaling also inhibited the suppressive function of purified CD4+CD25+CD127dim/− Tregs from GC patients, which presented as elevation of cellular proliferation and IL-35 secretion. The current data further provided mechanism underlying Tregs–Th17 balance in GC patients. The link between Notch signaling and Th cells might lead to a new therapeutic target for GC patients.

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