Evaluating Zika Virus Pathogenesis in Immunocompromised Mice

2020 ◽  
pp. 23-40
Author(s):  
Bryan D. Griffin ◽  
David Safronetz ◽  
Darwyn Kobasa
Keyword(s):  
Zika Virus ◽  
Immunocompromised Mice

scholarly journals Preventive effects of folic acid on Zika virus-associated poor pregnancy outcomes in immunocompromised mice

2020 ◽  
Vol 16 (5) ◽  
pp. e1008521
Author(s):  
Yogy Simanjuntak ◽  
Hui-Ying Ko ◽  
Yi-Ling Lee ◽  
Guann-Yi Yu ◽  
Yi-Ling Lin
Keyword(s):  
Folic Acid ◽  
Pregnancy Outcomes ◽  
Zika Virus ◽  
Immunocompromised Mice ◽  
Preventive Effects

scholarly journals Using immunocompromised mice to identify mechanisms of Zika virus transmission and pathogenesis

Immunology ◽  
2018 ◽  
Vol 153 (4) ◽  
pp. 443-454 ◽  
Author(s):  
Clayton W. Winkler ◽  
Karin E. Peterson
Keyword(s):  
Zika Virus ◽  
Virus Transmission ◽  
Immunocompromised Mice

scholarly journals Mapping the evolutionary landscape of Zika virus infection in immunocompromised mice

2020 ◽  
Vol 6 (2) ◽  
Author(s):  
Katherine E E Johnson ◽  
Maria G Noval ◽  
Margarita V Rangel ◽  
Elfie De Jesus ◽  
Adam Geber ◽  
...  
Keyword(s):  
Zika Virus ◽  
Viral Genome ◽  
Transmission Model ◽  
Transmission Route ◽  
Zikv Infection ◽  
Adaptive Process ◽  
Specific Organ ◽  
Vector Borne ◽  
Immunocompromised Mice

Abstract The fundamental basis of how arboviruses evolve in nature and what regulates the adaptive process remain unclear. To address this problem, we established a Zika virus (ZIKV) vector-borne transmission system in immunocompromised mice to study the evolutionary characteristics of ZIKV infection. Using this system, we defined factors that influence the evolutionary landscape of ZIKV infection and show that transmission route and specific organ microenvironments impact viral diversity and defective viral genome production. In addition, we identified in mice the emergence of ZIKV mutants previously seen in natural infections, including variants present in currently circulating Asian and American strains, as well as mutations unique to the mouse infections. With these studies, we have established an insect-to-mouse transmission model to study ZIKV evolution in vivo. We also defined how organ microenvironments and infection route impact the ZIKV evolutionary landscape, providing a deeper understanding of the factors that regulate arbovirus evolution and emergence.

scholarly journals Mapping the evolutionary landscape of Zika virus infection in immunocompromised mice

2019 ◽  
Author(s):  
Maria G. Noval ◽  
Margarita V. Rangel ◽  
Katherine E. Johnson ◽  
Elfie De Jesus ◽  
Adam Gerber ◽  
...  
Keyword(s):  
Zika Virus ◽  
Viral Genome ◽  
Transmission Model ◽  
Viral Diversity ◽  
Transmission Route ◽  
Zikv Infection ◽  
Adaptive Process ◽  
Specific Organ ◽  
Vector Borne ◽  
Immunocompromised Mice

AbstractThe fundamental basis of how arboviruses evolve in nature and what regulates the adaptive process remain unclear. To address this problem, we established a Zika virus (ZIKV) vector-borne transmission system in immunocompromised mice that mimics evolutionary characteristics of ZIKV infection in humans. Using this system, we defined factors that influence the evolutionary landscape of ZIKV infection and show that transmission route and specific organ microenvironments impact viral diversity and defective viral genome (DVG) production. In addition, we identified in mice the emergence of ZIKV mutants previously seen in natural infections, including variants present in currently circulating strains, as well as mutations unique to the mouse infections. With these studies, we have established an insect-to-mouse transmission model to study ZIKV evolution. We also defined how organ microenvironments and infection route impact the ZIKV evolutionary landscape, providing a deeper understanding of the factors that regulate arbovirus evolution and emergence.

Preventing Transmission of Zika Virus in Labor and Delivery Settings Through Implementation of Standard Precautions — United States, 2016

2016 ◽  
Vol 65 (11) ◽  
Author(s):  
Christine K. Olson ◽  
Martha Iwamoto ◽  
Kiran M. Perkins ◽  
Kara N.D. Polen ◽  
Jeffrey Hageman ◽  
...  
Keyword(s):  
United States ◽  
Zika Virus ◽  
Labor And Delivery ◽  
Standard Precautions

Increase in Reported Prevalence of Microcephaly in Infants Born to Women Living in Areas with Confirmed Zika Virus Transmission During the First Trimester of Pregnancy — Brazil, 2015

2016 ◽  
Vol 65 (9) ◽  
Author(s):  
Wanderson Kleber de Oliveira ◽  
Juan Cortez-Escalante ◽  
Wanessa Tenório Gonçalves Holanda De Oliveira ◽  
Greice Madeleine Ikeda do Carmo ◽  
Cláudio Maierovitch Pessanha Henriques ◽  
...  
Keyword(s):  
Zika Virus ◽  
Virus Transmission ◽  
First Trimester ◽  
First Trimester Of Pregnancy

Increase in Reported Prevalence of Microcephaly in Infants Born to Women Living in Areas with Confirmed Zika Virus Transmission During the First Trimester of Pregnancy — Brazil, 2015

2016 ◽  
Vol 65 (9) ◽  
pp. 242-247 ◽  
Author(s):  
Wanderson Kleber de Oliveira ◽  
Juan Cortez-Escalante ◽  
Wanessa Tenório Gonçalves Holanda De Oliveira ◽  
Greice Madeleine Ikeda do Carmo ◽  
Cláudio Maierovitch Pessanha Henriques ◽  
...  
Keyword(s):  
Zika Virus ◽  
Virus Transmission ◽  
First Trimester ◽  
First Trimester Of Pregnancy

Transmission of Zika Virus Through Sexual Contact with Travelers to Areas of Ongoing Transmission — Continental United States, 2016

2016 ◽  
Vol 65 (8) ◽  
Author(s):  
Susan L. Hills ◽  
Kate Russell ◽  
Morgan Hennessey ◽  
Charnetta Williams ◽  
Alexandra M. Oster ◽  
...  
Keyword(s):  
United States ◽  
Zika Virus ◽  
Sexual Contact
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