scholarly journals Preventive effects of folic acid on Zika virus-associated poor pregnancy outcomes in immunocompromised mice

2020 ◽  
Vol 16 (5) ◽  
pp. e1008521
Author(s):  
Yogy Simanjuntak ◽  
Hui-Ying Ko ◽  
Yi-Ling Lee ◽  
Guann-Yi Yu ◽  
Yi-Ling Lin
Keyword(s):  
Folic Acid ◽  
Pregnancy Outcomes ◽  
Zika Virus ◽  
Immunocompromised Mice ◽  
Preventive Effects

Evaluating Zika Virus Pathogenesis in Immunocompromised Mice

2020 ◽  
pp. 23-40
Author(s):  
Bryan D. Griffin ◽  
David Safronetz ◽  
Darwyn Kobasa
Keyword(s):  
Zika Virus ◽  
Immunocompromised Mice

scholarly journals Embryotoxic impact of Zika virus in a rhesus macaque in vitro implantation model†

2020 ◽  
Vol 102 (4) ◽  
pp. 806-816 ◽  
Author(s):  
Lindsey N Block ◽  
Matthew T Aliota ◽  
Thomas C Friedrich ◽  
Michele L Schotzko ◽  
Katherine D Mean ◽  
...  
Keyword(s):  
Rhesus Macaque ◽  
Pregnancy Outcomes ◽  
Zika Virus ◽  
Negative Impact ◽  
Culture Media ◽  
Blastocyst Formation ◽  
Placental Development ◽  
Zikv Infection ◽  
The Impact

Abstract Zika virus (ZIKV) infection is associated with adverse pregnancy outcomes in humans, and infection in the first trimester can lead to miscarriage and stillbirth. Vertical and sexual transmissions of ZIKV have been demonstrated, yet the impact of infection during the initial stages of pregnancy remains unexplored. Here we defined the impact of ZIKV on early embryonic and placental development with a rhesus macaque model. During in vitro fertilization (IVF), macaque gametes were inoculated with a physiologically relevant dose of 5.48log10 plaque-forming units (PFU) of Zika virus/H.sapiens-tc/PUR/2015/PRVABC59_v3c2. Exposure at fertilization did not alter blastocyst formation rates compared to controls. To determine the impact of ZIKV exposure at implantation, hatched blastocysts were incubated with 3.26log10, 4.26log10, or 5.26log10 PFU, or not exposed to ZIKV, followed by extended embryo culture for 10 days. ZIKV exposure negatively impacted attachment, growth, and survival in comparison to controls, with exposure to 5.26log10 PFU ZIKV resulting in embryonic degeneration by day 2. Embryonic secretion of pregnancy hormones was lower in ZIKV-exposed embryos. Increasing levels of infectious virus were detected in the culture media post-exposure, suggesting that the trophectoderm is susceptible to productive ZIKV infection. These results demonstrate that ZIKV exposure severely impacts the zona-free blastocyst, whereas exposure at the time of fertilization does not hinder blastocyst formation. Overall, early stages of pregnancy may be profoundly sensitive to infection and pregnancy loss, and the negative impact of ZIKV infection on pregnancy outcomes may be underestimated.

scholarly journals Adding folic acid to corn Masa flour: Partnering to improve pregnancy outcomes and reduce health disparities

2018 ◽  
Vol 106 ◽  
pp. 26-30 ◽  
Author(s):  
Alina L. Flores ◽  
Amy M. Cordero ◽  
Michael Dunn ◽  
Joseph E. Sniezek ◽  
Miguel A. Arce ◽  
...  
Keyword(s):  
Health Disparities ◽  
Folic Acid ◽  
Pregnancy Outcomes ◽  
Corn Masa

The preventive effects of edible folic acid on cardiomyocyte apoptosis and survival in early onset triple-transgenic Alzheimer's disease model mice

2017 ◽  
Vol 33 (1) ◽  
pp. 83-92 ◽  
Author(s):  
Kuan-Ho Lin ◽  
Chih-Hao Chiu ◽  
Wei-Wen Kuo ◽  
Da-Tong Ju ◽  
Chia-Yao Shen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Folic Acid ◽  
Early Onset ◽  
Disease Model ◽  
Cardiomyocyte Apoptosis ◽  
Preventive Effects

Homocysteine, folic acid and vitamin B12 in relation to pre- and postnatal health aspects

2005 ◽  
Vol 43 (10) ◽  
Author(s):  
Rima Obeid ◽  
Wolfgang Herrmann
Keyword(s):  
Folic Acid ◽  
Vitamin B12 ◽  
Pregnancy Outcomes ◽  
Pregnancy Complications ◽  
Plasma Homocysteine ◽  
Vitamin B ◽  
Total Plasma ◽  
Vitamin Status ◽  
B Vitamin ◽  
Early Abortion

AbstractStudies linking hyperhomocysteinemia (HHCY) and B-vitamin deficiency to some health aspects in children have been accumulating. Low B-vitamin status inearly life, even as early as the time of conception, may endanger the potential for new life and may negatively influence the health of the offspring. Early abortion, pregnancy complications and poor pregnancy outcomes have been linked to elevated concentrations of total plasma homocysteine (tHcy) and low folate or vitamin B

scholarly journals Adequacy of Nutrients Intake among Jordanian Pregnant Women in Comparison to Dietary Reference Intakes

2019 ◽  
Vol 16 (18) ◽  
pp. 3440 ◽  
Author(s):  
Reema F. Tayyem ◽  
Sabika S. Allehdan ◽  
Razan M. Alatrash ◽  
Fida F. Asali ◽  
Hiba A. Bawadi
Keyword(s):  
Folic Acid ◽  
Pregnant Women ◽  
Pregnancy Outcomes ◽  
Maternal Nutrition ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Food Sources ◽  
Cross Sectional ◽  
Dietary Reference Intakes ◽  
Demographic Questionnaire

Objective: Maternal nutrition is considered an important pillar in the pregnancy outcomes for both mother and infant. A mother’s malnutrition and inadequate nutrient intake is associated with many undesirable pregnancy outcomes. Hence, assessing the nutritional status of the mother in the early stages of the pregnancy and preventing any inadequacy can preclude many health problems for both mother and infant. Therefore, this study aimed to assess the adequacy of nutrient intakes among Jordanian pregnant women as compared to their corresponding dietary reference intakes (DRIs). Methods: This cross-sectional study was conducted at a major University Hospital in Jordan. Three hundred pregnant women were invited to participate in the study and 286 agreed to participate. Fifty pregnant women were enrolled at week 9, then 96 pregnant women were at week 20 and 137 pregnant women were at week 30 of pregnancy. The participants completed the interview-based demographic questionnaire, pregnancy physical activity questionnaire, and quantitative food frequency questionnaire (FFQ). Results: The mean energy intake was 2768.9 ± 767.8 kcal/day and it was significantly higher in the 3rd trimester (p < 0.05). Women in the 3rd trimester consumed significantly more protein, carbohydrates, and sugar than women in the 1st and 2nd trimesters (p < 0.05). The pregnant women in the 3rd trimester consumed more sodium than women in the 1st and 2nd trimesters (p < 0.05). The vitamin K intake was significantly (p = 0.045) lower in the 2nd trimester than the 1st and 3rd trimesters. The calcium intake was significantly higher in the 3rd trimester than the 1st and 2nd trimesters (p = 0.021). The total micronutrient (vitamins B1, B2, B3, B6, B12, and D, calcium, and iron) intakes derived from dietary supplements and food sources throughout the 3 trimesters was significantly higher in the 3rd trimester than the 1st and 2nd trimesters (p < 0.05). The vitamin D, calcium, and iron intakes had the most significant increases between the 1st and 3rd trimesters (p < 0.001), while folic acid intake was significantly higher in the 1st trimester than the 2nd and 3rd trimester (p < 0.001). Most women exceeded the tolerable upper intake level (UL) for sodium in all trimesters, while 82% of women exceeded the UL of folic acid in the 1st trimester and from the supplement, not the diet. Conclusion: While the intake of some nutrients from food alone remains below the DRIs in the diets of pregnant women, the intake of other nutrients is above the UL. Raising the awareness of pregnant women about their diet and how a supplement intake can reduce the risk of inadequate intake for many micronutrients and improve their pregnancy outcomes is of great importance.

scholarly journals Pregnancy outcomes after maternal Zika virus infection in a non-endemic region: prospective cohort study

2019 ◽  
Vol 25 (5) ◽  
pp. 633.e5-633.e9 ◽  
Author(s):  
C. Rodó ◽  
A. Suy ◽  
E. Sulleiro ◽  
A. Soriano-Arandes ◽  
N. Maiz ◽  
...  
Keyword(s):  
Cohort Study ◽  
Virus Infection ◽  
Prospective Cohort Study ◽  
Pregnancy Outcomes ◽  
Zika Virus ◽  
Prospective Cohort ◽  
Endemic Region ◽  
Zika Virus Infection

scholarly journals Using immunocompromised mice to identify mechanisms of Zika virus transmission and pathogenesis

Immunology ◽  
2018 ◽  
Vol 153 (4) ◽  
pp. 443-454 ◽  
Author(s):  
Clayton W. Winkler ◽  
Karin E. Peterson
Keyword(s):  
Zika Virus ◽  
Virus Transmission ◽  
Immunocompromised Mice
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