Conotruncal Malformation Complex: Examples of Possible Monogenic Inheritance

PEDIATRICS ◽  
1979 ◽  
Vol 63 (6) ◽  
pp. 890-893
Author(s):  
Marvin E. Miller ◽  
David W. Smith
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Family History ◽  
Congenital Heart ◽  
Recurrence Risk ◽  
Strong Family History ◽  
Cardiac Defects ◽  
Monogenic Inheritance ◽  
Congenital Cardiac Defects ◽  
Malformation Complex

Two families are described in which there is possible monogenic inheritance of congenital cardiac defects within the spectrum of faulty conotruncal septation (CTS). Evidence for a genetic control of conotruncal septation arises from genetic and embryologic studies of similar defects in the Keeshond dog model, the excess of sibship pairs with conotruncal septation defects in sibship pairs with congenital heart disease, and previously reported pedigrees of families with multiple affected individuals with conotruncal septation defects. It is suggested that in the small number of cases of congenital cardiac defects in which there is a strong family history for CTS defects, a higher recurrence risk should be considered rather than the usual polygenic recurrence risk of 3% that is usually given in such situations.

scholarly journals Genetic control of Pyrenophora teres virulence to three barley accessions

2017 ◽  
Vol 38 (SI 2 - 6th Conf EFPP 2002) ◽  
pp. 612-614
Author(s):  
N. Mironenko ◽  
O. Filatova ◽  
O. Afanasenko
Keyword(s):  
Genetic Control ◽  
Resistance Genes ◽  
Pyrenophora Teres ◽  
Avirulence Genes ◽  
Monogenic Inheritance ◽  
Barley Resistance ◽  
Barley Genotypes

Ascospore progeny of cross of Pyrenophora teres f. teres isolates was evaluated on virulence to three barley genotypes. Monogenic inheritance of virulence (26 a:17 v and 31 a:18 v) was shown to cultivar Harbin and accession c 21272 and supported by results of two fungal backcrosses. The existence of three unlinked avirulence genes to CI 4922 is suggested (37 a:7 v). The model of interaction between barley resistance genes and avirulence genes with postulated fungal genotypes is proposed.

scholarly journals Basic Mechanisms of Monogenic Inheritance

Epilepsia ◽  
1999 ◽  
Vol 40 (s3) ◽  
pp. 4-8 ◽  
Author(s):  
Andreas Ziegler
Keyword(s):  
Monogenic Inheritance

Aluminium tolerance in lentil (Lens culinarisMedik.) with monogenic inheritance pattern

2014 ◽  
Vol 134 (1) ◽  
pp. 105-110 ◽  
Author(s):  
Dharmendra Singh ◽  
Harsh Kumar Dikshit ◽  
Arun Kumar
Keyword(s):  
Aluminium Tolerance ◽  
Inheritance Pattern ◽  
Monogenic Inheritance

scholarly journals HCC and liver disease risks in homozygous PNPLA3 p.I148M carriers approach monogenic inheritance

2015 ◽  
Vol 62 (4) ◽  
pp. 980-981 ◽  
Author(s):  
Marcin Krawczyk ◽  
Caroline S. Stokes ◽  
Stefano Romeo ◽  
Frank Lammert
Keyword(s):  
Liver Disease ◽  
Monogenic Inheritance ◽  
Disease Risks

scholarly journals Novel series os pea symbiotic mutants induced in the SGE line

2012 ◽  
Vol 10 (1) ◽  
pp. 19-26
Author(s):  
Viktor E Tsyganov ◽  
Vera A Voroshilova ◽  
Sergey M Rozov ◽  
Aleksey U Borisov ◽  
Igor A Tikhonovich
Keyword(s):  
Mutant Phenotype ◽  
Complementation Analysis ◽  
Chemical Mutagenesis ◽  
Font Size ◽  
Monogenic Inheritance ◽  
Additional Mutation ◽  
Recessive Phenotype ◽  
Laboratory Line

 Using ethylmethansulphonate the chemical mutagenesis of the pea laboratory line SGE was performed. During analysis of 425 families (2069 plants) of М<sub>2</sub> progeny 45 putative mutants were selected, among them 30 mutants forming ineffective nodules (Fix<sup>–</sup> phenotype), 13 mutantsunable to form nodules (Nod<sup>–</sup> phenotype), and 2 mutants forming a few nodules (Nod<sup>+/–</sup> phenotype). For 1 Nod<sup>–</sup> and 5 Fix<sup>–</sup> mutants monogenic inheritance and recessive phenotype manifestation were demonstrated. For Fix<sup>– </sup>mutant SGEFix<sup>–</sup>–9 an additional mutation leading to Nod<sup>+/–</sup> phenotype was shown. Complementation analysis showed that the mutant phenotype of the SGEFix<span style="font-size:11px"><sup>-</sup> - </span>5 line is caused by a mutation in the sym33 gene, of theSGEFix<sup>–</sup>–6 linein the sym40 gene, of the SGEFix<sup>–</sup>–7 line in the sym27 gene, and of the SGEFix<sup>–</sup>–8 linein the sym25 gene.

scholarly journals Inheritance of cowpea resistance to Cowpea aphid-borne mosaic vírus

2021 ◽  
Vol 56 ◽  
Author(s):  
Jeferson Araújo Silva ◽  
Antonio Félix da Costa ◽  
Ana Maria Benko-Iseppon ◽  
Lílian Margarete Paes Guimarães ◽  
Diego Arruda Huggins de Sá Leitão ◽  
...  
Keyword(s):  
Mosaic Virus ◽  
Vigna Unguiculata ◽  
Visual Inspection ◽  
Inheritance Of Resistance ◽  
Chi Square ◽  
Monogenic Inheritance ◽  
Cowpea Resistance ◽  
Cowpea Aphid ◽  
Chi Square Test

Abstract: The objective of this work was to evaluate the inheritance of resistance to Cowpea aphid-borne mosaic virus (CABMV) in cowpea (Vigna unguiculata). The study was performed between parental genotypes IT85F-2687 (resistant) and 'BR-14 Mulato' (susceptible), generating F1, F2, and F7 populations and backcrosses with both parental genotypes. CABMV was inoculated on plants from all generations, which were then evaluated through visual inspection and description of characteristic symptoms. A chi-square test was performed after the phenotypic classification of all plants. A segregation proportion of 1:3 (resistant:susceptible) in population F2 and of 1:1 in population F7 was accepted, showing a recessive monogenic inheritance.

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