Non-Small Cell Lung Carcinoma: EGFR Gene Mutations and Response to Gefitinib

2008 ◽  
pp. 291-306
Author(s):  
Armando Bartolazzi
Keyword(s):  
Lung Carcinoma ◽  
Small Cell Lung Carcinoma ◽  
Gene Mutations ◽  
Small Cell ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma ◽  
Egfr Gene

Relationship between driver gene mutations, their relative protein expressions and survival in non‐small cell lung carcinoma in Macao

2017 ◽  
Vol 12 (4) ◽  
pp. 1416-1423
Author(s):  
Kin Iong Chan ◽  
Hong Ting Vong ◽  
Lai Fong Sin ◽  
Yuk Ching Yip ◽  
Xue Yun Zhong ◽  
...  
Keyword(s):  
Lung Carcinoma ◽  
Small Cell Lung Carcinoma ◽  
Gene Mutations ◽  
Small Cell ◽  
Driver Gene ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma ◽  
Protein Expressions

scholarly journals A Case of Small-cell Lung Carcinoma with EGFR Gene Mutation

Haigan ◽  
2011 ◽  
Vol 51 (7) ◽  
pp. 798-802 ◽  
Author(s):  
Sodai Narumi ◽  
Akira Inoue ◽  
Taizo Shibahara ◽  
Ryotaro Igusa ◽  
Tomohiro Sakakibara ◽  
...  
Keyword(s):  
Gene Mutation ◽  
Lung Carcinoma ◽  
Small Cell Lung Carcinoma ◽  
Small Cell ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma ◽  
Egfr Gene ◽  
Egfr Gene Mutation

scholarly journals Analysis of the effect of NEKs on the prognosis of patients with Non-small-cell lung carcinoma based on bioinformatics

2021 ◽  
Author(s):  
MENGXIA YANG ◽  
YIKUN GUO ◽  
XIAOFEI GUO ◽  
YUN MAO ◽  
SHIJIE ZHU ◽  
...  
Keyword(s):  
Lung Carcinoma ◽  
Small Cell Lung Carcinoma ◽  
Gene Mutations ◽  
Tumor Stage ◽  
Good Prognosis ◽  
Small Cell ◽  
High Expression ◽  
Clinicopathological Parameters ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma

Abstract NEKs are proteins that are involved in various cell processes and play important roles in the formation and development of cancer. However, few studies have examined the role of NEKs in the development of non-small-cell lung carcinoma (NSCLC). To address this problem, the Oncomine, UALCAN, and the Human Protein Atlas databases were used to analyze differential NEK expression and its clinicopathological parameters, while the Kaplan-Meier, cBioPortal, GEPIA, and DAVID databases were used to analyze survival, gene mutations, similar genes, and biological enrichments. The rate of NEK family gene mutation was high (>50%) in patients with NSCLC, in which NEK2/4/6/8/ was overexpressed and significantly correlated with tumor stage and nodal metastasis status. In addition, the high expression of NEK2/3mRNA was significantly associated with poor prognosis in patients with NSCLC, while high expression of NEK1/4/6/7/8/9/10/11mRNA was associated with good prognosis. In summary, these results suggest that NEK2/4/6/8 may be a potential prognostic biomarker for the survival of patients with NSCLC.

Clinical Features And Outcomes Of Patients With Small Cell Lung Carcinoma; Retrospective Analysis

2015 ◽  
Vol 3 (2) ◽  
pp. 47 ◽  
Author(s):  
Duygu Unalmış ◽  
Zehra Yasar ◽  
Melih Buyuksirin ◽  
Gulru Polat ◽  
Fatma Demirci Ucsular ◽  
...  
Keyword(s):  
Retrospective Analysis ◽  
Clinical Features ◽  
Lung Carcinoma ◽  
Small Cell Lung Carcinoma ◽  
Small Cell ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma
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