The Immune Risk Profile and Associated Parameters in Late Life: Lessons from the OCTO and NONA Longitudinal Studies

2009 ◽  
pp. 3-28 ◽  
Author(s):  
Anders Wikby ◽  
Jan Strindhall ◽  
Boo Johansson
2017 ◽  
Vol 1 (suppl_1) ◽  
pp. 211-211
Author(s):  
M. Caldeira ◽  
M. Brunialti ◽  
R. Salomão ◽  
C. Mello Almada Filho ◽  
M. Cendoroglo

2007 ◽  
Vol 42 (8) ◽  
pp. 753-761 ◽  
Author(s):  
Jan Strindhall ◽  
Bengt-Olof Nilsson ◽  
Sture Löfgren ◽  
Jan Ernerudh ◽  
Graham Pawelec ◽  
...  

2011 ◽  
Vol 24 (4) ◽  
pp. 524-531 ◽  
Author(s):  
Charlotte L. Allan ◽  
Claire E. Sexton ◽  
Ukwuori G. Kalu ◽  
Lisa M. McDermott ◽  
Mika Kivimäki ◽  
...  

ABSTRACTBackground: Cardiovascular risk factors and diseases are important etiological factors in depression, particularly late-life depression. Brain changes associated with vascular disease and depression can be detected using magnetic resonance imaging. Using diffusion tensor imaging (DTI), we investigated whether the Framingham Stroke Risk Profile (FSRP), a well-validated risk prediction algorithm, is associated with changes in white-matter connectivity. We hypothesized that depressed participants would show reduced white-matter integrity with higher FSRP, and non-depressed controls (matched for mean vascular risk) would show minimal co-variance with white-matter changes.Methods: Thirty-six participants with major depression (age 71.8 ± 7.7 years, mean FSRP 10.3 ± 7.6) and 25 controls (age 71.8 ± 7.3 years, mean FSRP 10.1 ± 7.7) were clinically interviewed and examined, followed by 60-direction DTI on a 3.0 Tesla scanner. Image analysis was performed using FSL tools (www.fmrib.ox.ac.uk/fsl) to assess the correlation between FSRP and fractional anisotropy (FA). Voxelwise statistical analysis of the FA data was carried out using Tract Based Spatial Statistics. The significance threshold for correlations was set at p < 0.05 using threshold-free cluster-enhancement. Partial correlation analysis investigated significant correlations in each group.Results: Participants in the depressed group showed highly significant correlations between FSRP and FA within the body of corpus callosum (r = −0.520, p = 0.002), genu of corpus callosum (r = −0.468, p = 0.005), splenium of corpus callosum (r = −0.536, p = 0.001), and cortico-spinal tract (r = −0.473, p = 0.005). In controls, there was only one significant correlation in the body of corpus callosum (r = −0.473, p = 0.023).Conclusions: FSRP is associated with impairment in white-matter integrity in participants with depression; these results suggest support for the vascular depression hypothesis.


2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 921-922
Author(s):  
Penny Brennan

Abstract With this study we sought to determine how older adults’ stressors influence their levels and rates of change in pain during the late-life span. We harmonized repeated measures data from two parent longitudinal studies of aging and health, Longitudinal Late-Life Health (LLLH; n=1,1884) and the Health and Retirement Study (HRS; n=7,703), to determine how participants’ stressor levels in the domains of finances, spouse, children, extended family, and friends, and in stressors overall, influenced their average levels and rates of change in painful conditions, pain severity, and pain interference over 13-year (LLLH) and 8-year (HRS) intervals. Participants’ within-person stressor levels declined somewhat, whereas their number of painful conditions, pain severity, pain interference, and prescription painkiller use increased steadily, over these intervals. In both the LLLH and HRS samples, participants who experienced higher average stressor levels over the 13- and 8-year intervals had more numerous painful conditions and higher pain severity over these intervals. In the HRS sample, they also experienced higher levels of pain interference. These effects occurred independent of the demographic characteristics of age, gender, and race. In general, participants’ stressor levels did not influence rates of increase in their pain. Gender and race had some moderating effects on associations between stressors and pain, but these occurred only within certain specific stressor and pain domains. These findings demonstrate an association between stressors and pain across the late-life course. Further research is needed to determine the mediating mechanisms that account for this association and the moderating factors that affect its strength.


2019 ◽  
Vol 10 ◽  
Author(s):  
David DeWolfe ◽  
Malika Aid ◽  
Kevin McGann ◽  
Joshua Ghofrani ◽  
Emma Geiger ◽  
...  

2012 ◽  
Vol 28 (4) ◽  
pp. 417-423 ◽  
Author(s):  
Christopher M. Marano ◽  
Clifford I. Workman ◽  
Elisse Kramer ◽  
Carol R. Hermann ◽  
Yilong Ma ◽  
...  

2008 ◽  
Vol 9 (5) ◽  
pp. 299-308 ◽  
Author(s):  
Anders Wikby ◽  
Ingrid A. Månsson ◽  
Boo Johansson ◽  
Jan Strindhall ◽  
Sven E. Nilsson

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