Pre-transplant end-stage renal disease-related immune risk profile in kidney transplant recipients predicts post-transplant infections

2016 ◽  
Vol 18 (3) ◽  
pp. 415-422 ◽  
Author(s):  
T. Crepin ◽  
E. Gaiffe ◽  
C. Courivaud ◽  
C. Roubiou ◽  
C. Laheurte ◽  
...  
Keyword(s):  
Renal Disease ◽  
Kidney Transplant ◽  
End Stage Renal Disease ◽  
Risk Profile ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Immune Risk Profile ◽  
Post Transplant ◽  
Stage Renal Disease ◽  
End Stage

P1732RECURRENCE OF GLOMERULONEPHRITIS POST TRANSPLANT

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Umesh Lingaraj ◽  
Ricken Mehta ◽  
Shivaprasad SM ◽  
Kishan A ◽  
Leelavathi V ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Renal Disease ◽  
Kidney Transplant ◽  
End Stage Renal Disease ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Post Transplant ◽  
Stage Renal Disease ◽  
End Stage

Abstract Background and Aims Glomerulonephritis (GN) is a major cause of end stage renal disease (ESRD)1. It represents the primary cause of end stage renal disease (ESRD) for 25% of the dialysis population1 and 45% of the transplant population. For patients with GN requiring renal replacement therapy, kidney transplantation is associated with superior outcomes compared with dialysis2. The possibility of recurrence of the original disease after transplantation was described in a seminal paper more than 40 years ago, and it is now clear that all forms of GN may recur after kidney transplantation.3 To study the recurrence of glomerulonephritis post-transplant in a tertiary care centre. Method 120 renal transplant recipients were analyzed from September 2015 to August 2019 at the Institute of Nephro-Urology, Bangalore. It was a retrospective analysis of data Results 120 adult patients underwent kidney transplantation, out of these 70 had GN as primary cause of kidney disease. 85.8% were males, 14.2 % females. 58.9 % were biopsy proven GN, remaining 41.1 % diagnosed based on history and clinical presentation. All but one patient had their first transplant. Out of these kidney transplant recipients 08 (11.4%) had recurrence of GN.  From these 4/08 was recurrent IgA N, 2/08 were PGNMID, 1/08 MGN, 1/08 aHUS. Graft loss due to recurrent GN was seen in 1/08 patients (12.5%). Conclusion Our study showed that 11.4 % of kidney transplant recipients with GN as their cause of ESRD had recurrent GN post kidney transplantation. IgAN was the most type of GN that recurred most frequently followed by PGNMID. Recurrence of GN was in par with other studies and did not affect graft survival

Does Etiology of End-Stage Renal Disease Affect Sleep Quality in Kidney Transplant Recipients?

2007 ◽  
Vol 39 (4) ◽  
pp. 1091-1094 ◽  
Author(s):  
J. Ameli ◽  
H. Kachuee ◽  
S. Assari ◽  
V.R. Rasta ◽  
H.R. Khoddami-Vishte ◽  
...  
Keyword(s):  
Renal Disease ◽  
Sleep Quality ◽  
Kidney Transplant ◽  
End Stage Renal Disease ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Stage Renal Disease ◽  
End Stage

scholarly journals Risks and Benefits of Kidney Transplantation during the COVID Pandemic: Transplant or Not Transplant?

Kidney360 ◽  
2021 ◽  
pp. 10.34067/KID.0002532021
Author(s):  
Maria Ajaimy ◽  
Luz Liriano-Ward ◽  
Jay A Graham ◽  
Enver Akalin
Keyword(s):  
Renal Disease ◽  
Kidney Transplant ◽  
End Stage Renal Disease ◽  
Donor Selection ◽  
Waiting List ◽  
Morbidity And Mortality ◽  
Kidney Transplant Recipients ◽  
Risks And Benefits ◽  
Stage Renal Disease ◽  
End Stage

COVID-19 disease has significantly affected the transplant community by leading to decreased transplant activity and increased waiting list time. As expected, COVID-19 causes substantial mortality in both end-stage renal disease and kidney transplant populations. This is due to underlying chronic kidney disease and a high prevalence of comorbid conditions such as diabetes mellitus, hypertension, and cardiovascular disease in this group. Transplant programs have faced the difficult decision of weighing the risks and benefits of transplantation during the pandemic. On one hand there is a risk of COVID-19 exposure leading to infection while patients are on maximum immunosuppression. Alternatively, there are risks of delaying transplantation, which will increase waitlist-time and may lead to waitlist-associated morbidity and mortality. Cautious and thoughtful selection of both the recipient's and donor's post-transplant management is required during the pandemic to mitigate the risk of morbidity and mortality associated with COVID-19. In this review article we aimed to discuss previous publications related to clinical outcomes of COVID-19 disease in kidney transplant recipients, end-stage renal disease patients on dialysis or on the transplant waiting-list and precautions transplant centers should take in decision making for recipient and donor selection and immunosuppressive management during the pandemic. Nevertheless, transplantation in this milieu does seem to be the correct decision with a careful patient and donor selection with safeguard protocols for infection prevention. Each center should do risk assessment based on their patient's age and medical comorbidities, waitlist time, degree of sensitization, cold ischemia time, status of vaccination, and severity of pandemic in their region.

scholarly journals Transfemoral transcatheter aortic valve implantation in patients with end-stage renal disease and kidney transplant recipients

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Fadi Al-Rashid ◽  
Anja Bienholz ◽  
Heike Annelie Hildebrandt ◽  
Polycarpos-Christos Patsalis ◽  
Matthias Totzeck ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Transcatheter Aortic Valve ◽  
Aortic Valve Implantation ◽  
Stage Renal Disease ◽  
End Stage ◽  
Valve Implantation

Insomnia severity in chronic kidney disease patients with various therapies

Open Medicine ◽  
2012 ◽  
Vol 7 (1) ◽  
pp. 112-117 ◽  
Author(s):  
Marinela Knezevic ◽  
Vladimir Djordjevic ◽  
Ivana Bivolarevic ◽  
Jelena Jovic ◽  
Vidojko Djordjević
Keyword(s):  
Peritoneal Dialysis ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Severity Index ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Insomnia Severity Index ◽  
Stage Renal Disease ◽  
End Stage ◽  
Insomnia Severity

AbstractThe prevalence of insomnia is greater in end-stage renal disease. The aim of our study was to determine the frequency of insomnia and subclinical insomnia in patients with various dialysis therapy and kidney transplant recipients, in order to assess the severity of insomnia and examine whether there is a difference in severity among groups. In cross-sectional study, we evaluated 120 patients with terminal renal failure. Based on therapy, patients were divided into four groups: hemodiafiltration, standard bicarbonate dialysis, peritoneal dialysis and kidney transplant recipients. The severity of insomnia was evaluated through the use of the Insomnia Severity Index (ISI). Most patients who reported any kind of insomnia problems with ISI were on conventional dialysis (80%), followed by hemodiafiltration (76.7%) and peritoneal dialysis (63.3%). Transplant recipients had least difficulties with insomnia (46.7%). Insomnia Severity Index showed that insomnia in end-stage renal patients is not very severe. Most of the patients had “no clinically significant insomnia”. Our findings indicate that patients on hemodiafiltration and transplant recipients have a significantly lower score on Insomnia Severity Index. Patients with end-stage renal disease have high frequency insomnia problems. However, our study shows that insomnia in these patients is not severe. Insomnia is the most frequent and severest in patients on standard bicarbonate dialysis.

Racial Differences in Access to the Kidney Transplant Waiting List for Children and Adolescents With End-Stage Renal Disease

PEDIATRICS ◽  
2000 ◽  
Vol 106 (4) ◽  
pp. 756-761 ◽  
Author(s):  
S. L. Furth ◽  
P. P. Garg ◽  
A. M. Neu ◽  
W. Hwang ◽  
B. A. Fivush ◽  
...  
Keyword(s):  
Renal Disease ◽  
Children And Adolescents ◽  
Kidney Transplant ◽  
Racial Differences ◽  
End Stage Renal Disease ◽  
Waiting List ◽  
Stage Renal Disease ◽  
End Stage

scholarly journals A patient with end-stage renal disease who recovered from coronavirus disease 2019 then received a kidney transplant

2021 ◽  
pp. 101395
Author(s):  
Tianyu Wang ◽  
Tao Qiu ◽  
Ming Wang ◽  
Yan Yuan ◽  
Zhongbao Chen ◽  
...  
Keyword(s):  
Renal Disease ◽  
Kidney Transplant ◽  
End Stage Renal Disease ◽  
Stage Renal Disease ◽  
End Stage

scholarly journals Coronary microvascular dysfunction is associated with degree of anaemia in end‐stage renal disease

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ashwin Radhakrishnan ◽  
Luke C. Pickup ◽  
Anna M. Price ◽  
Jonathan P. Law ◽  
Kirsty C. McGee ◽  
...  
Keyword(s):  
Confidence Interval ◽  
Renal Disease ◽  
Kidney Transplant ◽  
End Stage Renal Disease ◽  
Microvascular Dysfunction ◽  
Left Ventricular ◽  
Coronary Microvascular Dysfunction ◽  
Transplant Candidates ◽  
Stage Renal Disease ◽  
End Stage

Abstract Background Coronary microvascular dysfunction (CMD) is common in end-stage renal disease (ESRD) and is an adverse prognostic marker. Coronary flow velocity reserve (CFVR) is a measure of coronary microvascular function and can be assessed using Doppler echocardiography. Reduced CFVR in ESRD has been attributed to factors such as diabetes, hypertension and left ventricular hypertrophy. The contributory role of other mediators important in the development of cardiovascular disease in ESRD has not been studied. The aim of this study was to examine the prevalence of CMD in a cohort of kidney transplant candidates and to look for associations of CMD with markers of anaemia, bone mineral metabolism and chronic inflammation. Methods Twenty-two kidney transplant candidates with ESRD were studied with myocardial contrast echocardiography, Doppler CFVR assessment and serum multiplex immunoassay analysis. Individuals with diabetes, uncontrolled hypertension or ischaemic heart disease were excluded. Results 7/22 subjects had CMD (defined as CFVR < 2). Demographic, laboratory and echocardiographic parameters and serum biomarkers were similar between subjects with and without CMD. Subjects with CMD had significantly lower haemoglobin than subjects without CMD (102 g/L ± 12 vs. 117 g/L ± 11, p = 0.008). There was a positive correlation between haemoglobin and CFVR (r = 0.7, p = 0.001). Similar results were seen for haematocrit. In regression analyses, haemoglobin was an independent predictor of CFVR (β = 0.041 95% confidence interval 0.012–0.071, p = 0.009) and of CFVR < 2 (odds ratio 0.85 95% confidence interval 0.74–0.98, p = 0.022). Conclusions Among kidney transplant candidates with ESRD, there is a high prevalence of CMD, despite the absence of traditional risk factors. Anaemia may be a potential driver of microvascular dysfunction in this population and requires further investigation.

Sign in / Sign up

Export Citation Format

Share Document