A Deterministic, Mathematical Model for Hormonal Control of the Menstrual Cycle

2010 ◽  
pp. 39-58
Author(s):  
R. Drew Pasteur ◽  
James F. Selgrade
Keyword(s):  
Mathematical Model ◽  
Menstrual Cycle ◽  
Hormonal Control

Hormonal control of reproduction in the female: the menstrual cycle

2022 ◽  
pp. 433-472
Author(s):  
Elizabeth H. Holt ◽  
Beatrice Lupsa ◽  
Grace S. Lee ◽  
Hanan Bassyouni ◽  
Harry E. Peery
Keyword(s):  
Menstrual Cycle ◽  
Hormonal Control

Normal Menstrual Cycle

2018 ◽  
Author(s):  
Rebecca Pierson ◽  
Kelly Pagidas
Keyword(s):  
Menstrual Cycle ◽  
Luteinizing Hormone ◽  
Luteal Phase ◽  
Follicle Stimulating Hormone ◽  
Follicular Phase ◽  
Gonadotropin Releasing Hormone ◽  
Hormonal Control ◽  
Releasing Hormone ◽  
Normal Menstrual Cycle ◽  
Stimulating Hormone

A normal menstrual cycle is the end result of a sequence of purposeful and coordinated events that occur from intact hypothalamic-pituitary-ovarian and uterine axes. The menstrual cycle is under hormonal control in the reproductively active female and is functionally divided into two phases: the proliferative or follicular phase and the secretory or luteal phase. This tight hormonal control is orchestrated by a series of negative and positive endocrine feedback loops that alter the frequency of the pulsatile secretion of gonadotropin-releasing hormone (GnRH), the pituitary response to GnRH, and the relative secretion of luteinizing hormone and follicle-stimulating hormone from the pituitary gonadotrope with subsequent direct effects on the ovary to produce a series of sex steroids and peptides that aid in the generation of a single mature oocyte and the preparation of a receptive endometrium for implantation to ensue. Any derailment along this programmed pathway can lead to an abnormal menstrual cycle with subsequent impact on the ability to conceive and maintain a pregnancy. This review contains 7 figures and 26 references Key words: follicle-stimulating hormone, follicular phase, gonadotropin-releasing hormone, luteal phase, luteinizing hormone, menstrual cycle, ovulation, progesterone, proliferative phase, secretory phase

A mathematical model of the human menstrual cycle for the administration of GnRH analogues

2013 ◽  
Vol 321 ◽  
pp. 8-27 ◽  
Author(s):  
Susanna Röblitz ◽  
Claudia Stötzel ◽  
Peter Deuflhard ◽  
Hannah M. Jones ◽  
David-Olivier Azulay ◽  
...  
Keyword(s):  
Mathematical Model ◽  
Menstrual Cycle ◽  
Gnrh Analogues ◽  
Human Menstrual Cycle

scholarly journals A Mathematical Model of the Human Menstrual Cycle

1971 ◽  
Vol 11 (10) ◽  
pp. 835-848 ◽  
Author(s):  
W.J. Shack ◽  
P.Y. Tam ◽  
T.J. Lardner
Keyword(s):  
Mathematical Model ◽  
Menstrual Cycle ◽  
Human Menstrual Cycle

scholarly journals High-amplitude network co-fluctuations linked to variation in hormone concentrations over menstrual cycle

2021 ◽  
Author(s):  
Sarah Greenwell ◽  
Joshua Faskowitz ◽  
Laura Pritschet ◽  
Tyler Santander ◽  
Emily G. Jacobs ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Brain Activity ◽  
Endocrine System ◽  
High Amplitude ◽  
Brain Network ◽  
Hormonal Control ◽  
Single Individual ◽  
Hormonal Fluctuations ◽  
Network States

Many studies have shown that the human endocrine system modulates brain function, reporting associations between fluctuations in hormone concentrations and both brain activity and connectivity. However, how hormonal fluctuations impact fast changes in brain network structure over short timescales remains unknown. Here, we leverage ``edge time series'' analysis to investigate the relationship between high-amplitude network states and quotidian variation in sex steroid and gonadotropic hormones in a single individual sampled over the course of two endocrine states, across a natural menstrual cycle and under a hormonal regimen. We find that the frequency of high-amplitude network states are associated with follicle-stimulating and luteinizing hormone, but not the sex hormones estradiol and progesterone. Nevertheless, we show that scan-to-scan variation in the co-fluctuation patterns expressed during network states are robustly linked with the concentration of all four hormones, positing a network-level target of hormonal control. We conclude by speculating on the role of hormones in shaping ongoing brain dynamics.

Emergent Oscillations in Mathematical Model of the Human Menstrual Cycle

CNS Spectrums ◽  
2003 ◽  
Vol 8 (11) ◽  
pp. 805-814 ◽  
Author(s):  
Natalie L. Rasgon ◽  
Lara Pumphrey ◽  
Paolo Prolo ◽  
Shana Elman ◽  
Andre B. Negrao ◽  
...  
Keyword(s):  
Mathematical Model ◽  
Menstrual Cycle ◽  
Luteinizing Hormone ◽  
Follicle Stimulating Hormone ◽  
Oscillatory Behavior ◽  
Follicular Phase ◽  
Gonadal Steroids ◽  
Early Follicular Phase ◽  
Human Menstrual Cycle ◽  
Stimulating Hormone

ABSTRACTBackground:The aim of this study was to develop a mathematical model of the hypothalamo-pituitary-gonadal axis that would reflect available data in humans.Methods:A model of hormonal relationships at the early follicular and midluteal phases of the human menstrual cycle is proposed.Findings:Two distinct temporal patterns of oscillatory behavior have been demonstrated for both pituitary and gonadal steroids in the early follicular phase: first, rapid oscillations in gonadotropin releasing hormone, follicle stimulating hormone, and luteinizing hormone (Q∼1 hour) that were an immediate consequence of the programmed equations. Second, there were slower, undulating, emergent rhythms in luteinizing hormone and follicle stimulating hormone, and also in estrogen, having oscillatory periods of 2–12 hours. There was also a longer-period (Q2–3 days) emergent rhythm in progesterone. In the mid-luteal phase, estrogen and progesterone rhythms were correlated, and all hormones showed an ∼6-hour periodicity.Conclusion:To our knowledge, the oscillatory behavior of peripheral sex steroids in the follicular phase has not been previously noted.

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