Neural Connections Between the Lower Urinary Tract and the Spinal Cord

1987 ◽  
pp. 53-85 ◽  
Author(s):  
John F. B. Morrison
Keyword(s):  
Spinal Cord ◽  
Urinary Tract ◽  
Lower Urinary Tract ◽  
Neural Connections ◽  
Lower Urinary

Quantitation of lower urinary tract afferents in 3D reconstruction of lumbosacral spinal cord sections v1

2021 ◽  
Author(s):  
John-Paul Fuller-Jackson ◽  
Peregrine B Osborne ◽  
Janet R Keast
Keyword(s):  
Spinal Cord ◽  
Urinary Tract ◽  
3D Reconstruction ◽  
Lower Urinary Tract ◽  
Single Image ◽  
Toxin B ◽  
Image Stack ◽  
Lumbosacral Spinal Cord ◽  
Cholera Toxin B ◽  
Lower Urinary

This protocol details the 3D reconstruction of the lumbosacral spinal cord using alternating cryosections, and then goes through the steps required to quantify lower urinary tract afferents. Using TissueMaker (MBF Bioscience), images of alternating sections can be ordered and aligned prior to the production of a single image stack. In Neurolucida 360 (MBF Bioscience), regions of interest can be defined within the image stack, and the bouton-like immunolabelling of cholera toxin B can be segmented. Once saved, this data can then be extracted using Neurolucida Explorer (MBF Bioscience).

scholarly journals Pathophysiology of the lower urinary tract and CNS

2013 ◽  
Vol 5 (5-S2) ◽  
pp. 126
Author(s):  
Christopher Chapple
Keyword(s):  
Spinal Cord ◽  
Central Nervous System ◽  
Nervous System ◽  
Urinary Tract ◽  
Lower Urinary Tract ◽  
Neural Control ◽  
Neural Mechanisms ◽  
The Other ◽  
Bladder Function ◽  
Lower Urinary

A number of aspects of neural control are potentially important inthe control of bladder function, including both sensory and motorand peripheral and central pathways. It is likely that a combinationof disorders of both central and peripheral neural mechanisms isimportant in the genesis of urgency and the other symptoms of theoveractive bladder (OAB). Given the number of potential pathwaysinvolved, potential pharmacologic targets for OAB exist in the CNS(central nervous system; cerebral cortex, midbrain, spinal cord)and periphery (LUT; lower urinary tract). Antimuscarinics are stillthe mainstay of OAB treatment, but there are also a number ofother potentially efficacious drugs that may also provide benefitagainst the neurologic components of OAB. This review discussesthe impact of neurological abnormalities on lower urinary tractsymptoms and the potential for treatments targeting these pathwaysto improve symptoms.

scholarly journals Anti-Nogo-A Antibodies As a Potential Causal Therapy for Lower Urinary Tract Dysfunction after Spinal Cord Injury

2019 ◽  
Vol 39 (21) ◽  
pp. 4066-4076 ◽  
Author(s):  
Marc P. Schneider ◽  
Andrea M. Sartori ◽  
Benjamin V. Ineichen ◽  
Selina Moors ◽  
Anne K. Engmann ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Urinary Tract ◽  
Lower Urinary Tract ◽  
Lower Urinary Tract Dysfunction ◽  
Causal Therapy ◽  
Cord Injury ◽  
Lower Urinary

scholarly journals Clinical guidelines for the diagnosis and treatment of lower urinary tract dysfunction in patients with spinal cord injury

2020 ◽  
Vol 27 (4) ◽  
pp. 276-288 ◽  
Author(s):  
Noritoshi Sekido ◽  
Yasuhiko Igawa ◽  
Hidehiro Kakizaki ◽  
Takeya Kitta ◽  
Atsushi Sengoku ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Urinary Tract ◽  
Clinical Guidelines ◽  
Lower Urinary Tract ◽  
Diagnosis And Treatment ◽  
Lower Urinary Tract Dysfunction ◽  
Cord Injury ◽  
Lower Urinary
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