In Situ Analysis of Epstein-Barr Viral Expression in Nasopharyngeal Carcinoma

Author(s):  
Pathmanathan Rajadurai ◽  
K. Gilligan ◽  
U. Prasad ◽  
P. Busson ◽  
M. El-Sayed ◽  
...  
Oncology ◽  
1989 ◽  
Vol 46 (5) ◽  
pp. 310-317 ◽  
Author(s):  
Maria Li Lung ◽  
Kwok Hung Chan ◽  
Wai Pang Lam ◽  
Sio Kei Kou ◽  
Damon Choy ◽  
...  

2016 ◽  
Vol 25 (4) ◽  
pp. 304-309 ◽  
Author(s):  
Alicia Rumayor Piña ◽  
Harim Tavares dos Santos ◽  
Roman Carlos ◽  
Albina Altemani ◽  
Oslei Paes de Almeida

Background. Nasopharyngeal carcinoma (NPC) is highly associated with Epstein-Barr virus (EBV), particularly the undifferentiated nonkeratinizing subtype. Prevalence of EBV in NPC in countries such as Guatemala and Brazil has not been studied. Methods. We analyzed 19 cases of NPC, 11 from Guatemala and 8 from Brazil, for the presence of EBV by in situ hybridization and immunohistochemistry. Additionally, 19 hyperplastic adenoids from children were analyzed for EBV by in situ hybridization, 12 from Guatemala and 7 from Brazil. Results. All the NPC cases from Guatemala and 5 from Brazil were of the undifferentiated nonkeratinizing type. EBV-negative cases comprised 2 keratinizing NPC and 1 differentiated nonkeratinizing NPC. All undifferentiated nonkeratinizing NPC from both samples showed intense positivity for EBER, while LMP-1 only focally and scarcely expressed. EBER was positive in 75% and 43% of the adenoids from Guatemala and Brazil, respectively. Conclusions. All undifferentiated nonkeratinizing NPC irrespective of origin from Guatemala or Brazil were highly associated with EBV.


2006 ◽  
Vol 134 (4) ◽  
pp. 639-645 ◽  
Author(s):  
Kazunari Nakao ◽  
Masato Mochiki ◽  
Ken-Ichi Nibu ◽  
Masashi Sugasawa ◽  
Hiroshi Uozaki

2014 ◽  
Vol 05 (06) ◽  
pp. 517-522 ◽  
Author(s):  
Ameera A. M. Adam ◽  
Nazik E. Abdullah ◽  
Lamyaa A. M. El Hassan ◽  
Elwaleed M. Elamin ◽  
Muntaser E. Ibrahim ◽  
...  

1997 ◽  
Vol 107 (4) ◽  
pp. 523-526 ◽  
Author(s):  
Shigeyuki Murono ◽  
Tomokazu Yoshizaki ◽  
Saichiro Tanaka ◽  
Hajime Takeshita ◽  
Chang-Soo Park ◽  
...  

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