Indicator Dilution Methods

2000 ◽  
pp. 55-67
Author(s):  
Dale A. Schoeller
Keyword(s):  
Indicator Dilution

Simultaneous Red Cell and Plasma Protein Indicator-Dilution Curves Across the Peripheral Circulation During Open-Heart Surgery

Circulation ◽  
1966 ◽  
Vol 33 (4s1) ◽  
Author(s):  
STANLEY GIANNELLI ◽  
STEPHEN M. AYRES ◽  
WILLIAM I. WOLFF ◽  
META BUEHLER ◽  
E. FOSTER CONKLIN
Keyword(s):  
Plasma Protein ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
Peripheral Circulation ◽  
Indicator Dilution ◽  
Red Cell ◽  
Open Heart ◽  
Dilution Curves

scholarly journals Simulating a Ground Truth for Transit Time Analysis of Indicator Dilution Curves

2020 ◽  
Vol 6 (3) ◽  
pp. 268-271
Author(s):  
Michael Reiß ◽  
Ady Naber ◽  
Werner Nahm
Keyword(s):  
Transit Time ◽  
Sampling Rate ◽  
Ground Truth ◽  
Indicator Dilution ◽  
Cross Sectional ◽  
In Vivo Measurements ◽  
Multiple Indicator Dilution ◽  
Transit Times ◽  
Dilution Curves

AbstractTransit times of a bolus through an organ can provide valuable information for researchers, technicians and clinicians. Therefore, an indicator is injected and the temporal propagation is monitored at two distinct locations. The transit time extracted from two indicator dilution curves can be used to calculate for example blood flow and thus provide the surgeon with important diagnostic information. However, the performance of methods to determine the transit time Δt cannot be assessed quantitatively due to the lack of a sufficient and trustworthy ground truth derived from in vivo measurements. Therefore, we propose a method to obtain an in silico generated dataset of differently subsampled indicator dilution curves with a ground truth of the transit time. This method allows variations on shape, sampling rate and noise while being accurate and easily configurable. COMSOL Multiphysics is used to simulate a laminar flow through a pipe containing blood analogue. The indicator is modelled as a rectangular function of concentration in a segment of the pipe. Afterwards, a flow is applied and the rectangular function will be diluted. Shape varying dilution curves are obtained by discrete-time measurement of the average dye concentration over different cross-sectional areas of the pipe. One dataset is obtained by duplicating one curve followed by subsampling, delaying and applying noise. Multiple indicator dilution curves were simulated, which are qualitatively matching in vivo measurements. The curves temporal resolution, delay and noise level can be chosen according to the requirements of the field of research. Various datasets, each containing two corresponding dilution curves with an existing ground truth transit time, are now available. With additional knowledge or assumptions regarding the detection-specific transfer function, realistic signal characteristics can be simulated. The accuracy of methods for the assessment of Δt can now be quantitatively compared and their sensitivity to noise evaluated.

scholarly journals Oxygen delivery optimization using lithium indicator dilution and pulse power analysis during major surgery in high-risk patients

Critical Care ◽  
2007 ◽  
Vol 11 (Suppl 2) ◽  
pp. P305
Author(s):  
S Lobo ◽  
N Oliveira ◽  
F Lobo ◽  
E Rezende ◽  
B Borges ◽  
...  
Keyword(s):  
High Risk ◽  
Oxygen Delivery ◽  
Power Analysis ◽  
Indicator Dilution ◽  
Pulse Power ◽  
Major Surgery ◽  
High Risk Patients ◽  
Risk Patients

Random walk type models for indicator-dilution studies: comparison of a local density random walk and a first passage times distribution

1986 ◽  
Vol 20 (11) ◽  
pp. 789-796 ◽  
Author(s):  
J M BOGAARD ◽  
J R C JANSEN ◽  
E A VON RETH ◽  
A VERSPRILLE ◽  
M E WISE
Keyword(s):  
Random Walk ◽  
Local Density ◽  
Indicator Dilution ◽  
First Passage Times ◽  
First Passage ◽  
Passage Times

Physiological parameters of indicator dilution curves

1977 ◽  
Vol 233 (3) ◽  
pp. H350-H355
Author(s):  
L. D. Homer ◽  
A. Small
Keyword(s):  
Cardiac Output ◽  
Satisfactory Agreement ◽  
Single Injection ◽  
Time Lag ◽  
Volume Of Distribution ◽  
Physiological Parameters ◽  
Indicator Dilution ◽  
Diethylenetriaminepentaacetic Acid ◽  
Alternative Techniques ◽  
Dilution Curves

A model incorporating the effects of recirculation time lag, cardiac output, clearance, volume of distribution, and the variance of the distribution of recirculation times is applied to the analysis of indicator dilution curves. Experiments on dogs with use of radioactively labeled diethylenetriaminepentaacetic acid were done to evaluate the model. This five-parameter model can be fitted to data obtained during the period from less than 1 min to 3 h after a single injection of indicator. Estimates of cardiac output and clearance are in satisfactory agreement with estimates obtained by alternative techniques. Estimates of the time lag and volume of distribution are of physiologically plausible magnitude. The variance of the distribution of recirculation times is a new parameter, of which the possible usefulness to physiologists is discussed.

The Development of Indicator-Dilution Techniques

1984 ◽  
Vol BME-31 (12) ◽  
pp. 800-807 ◽  
Author(s):  
Edwin D. Trautman ◽  
Ronald S. Newbower
Keyword(s):  
Indicator Dilution ◽  
Indicator Dilution Techniques

scholarly journals Relative Effects of Heart Chambers, Lungs, and Mitral Insufficiency on the Shape of Indicator Dilution Curves

1959 ◽  
Vol 7 (1) ◽  
pp. 141-146 ◽  
Author(s):  
RICHARD W. EMANUEL ◽  
WILLIAM W. LACY ◽  
ELLIOT V. NEWMAN
Keyword(s):  
Indicator Dilution ◽  
Mitral Insufficiency ◽  
Dilution Curves

Detection and quantification of small left-to-right shunts by the phase-plane method

1983 ◽  
Vol 244 (4) ◽  
pp. H622-H627
Author(s):  
A. Fonseca-Costa ◽  
P. Magrassi ◽  
W. A. Zin ◽  
L. J. Romeo
Keyword(s):  
Sampling Method ◽  
Phase Plane ◽  
Sampling Site ◽  
Indicator Dilution ◽  
Terminal Portion ◽  
Systemic Artery ◽  
Anesthetized Dogs ◽  
Phase Plane Method ◽  
High Level ◽  
Dilution Curves

Sixty-five pairs of indicator-dilution curves were obtained in five anesthetized dogs. After the injection of indocyanine dye into the left atrium, blood was simultaneously sampled through dichromatic cuvette densitometers from the femoral artery and the distal pulmonary artery. Dye-dilution curves were recorded from dogs with normal cardiovascular systems and after the surgical production of left-to-right shunts of different magnitudes. The percent of blood shunting was calculated according to the double sampling method and compared with a new method based on the deviation observed in the terminal portion of the indicator-dilution phase-plane loop. A high level of correlation was observed between both methods (r = 0.961). The phase plane shows its utility in the quantification of small left-to-right shunts. The use of only one sampling site at a peripheral systemic artery is an important advantage because there is complete mixture between shunted and unshunted blood.

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