Evidence for Association of Epstein-Barr Virus with Malignant Lymphoepithelial Lesion of Salivary Gland

1987 ◽  
pp. 79-83 ◽  
Author(s):  
S. Clift ◽  
A. Lanier ◽  
K. Kline ◽  
W. Henle ◽  
G. Henle ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Epstein Barr Virus ◽  
Lymphoepithelial Lesion ◽  
Barr Virus ◽  
Epstein Barr

Lymphoepithelioma-like carcinoma of the submandibular salivary gland associated with Epstein?Barr virus in a North African woman

2004 ◽  
Vol 445 (4) ◽  
pp. 419-420 ◽  
Author(s):  
Karima Mrad ◽  
Ehsen Ben Brahim ◽  
Maha Driss ◽  
Imene Abbes ◽  
Mounir Marakchi ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Epstein Barr Virus ◽  
African Woman ◽  
Submandibular Salivary Gland ◽  
North African ◽  
Barr Virus ◽  
Epstein Barr

Undifferentiated Carcinoma with Lymphoid Stroma of the Major Salivary Glands

1990 ◽  
Vol 99 (3) ◽  
pp. 236-238 ◽  
Author(s):  
Karen R. Cleary ◽  
John G. Batsakis
Keyword(s):  
Salivary Glands ◽  
Epstein Barr Virus ◽  
Undifferentiated Carcinoma ◽  
Response To Therapy ◽  
Lymphoepithelial Carcinoma ◽  
Lymphoepithelial Lesion ◽  
Barr Virus ◽  
Lymphoid Stroma ◽  
Major Salivary Glands ◽  
Epstein Barr

Undifferentiated carcinoma with lymphoid stroma or lymphoepithelial carcinoma of the major salivary glands is a demographically and histopathologically unique malignancy. Although whites may have the disease, it is preponderantly a carcinoma of North American Eskimos and native Greenlanders. The carcinoma shares many features with undifferentiated nasopharyngeal carcinomas, from which it must be distinguished: histologic appearance, putative relationship with Epstein-Barr virus, predilection for mongoloid races, and response to therapy. In some cases, the carcinoma appears to have evolved from a lymphoepithelial lesion.

scholarly journals Detection of Epstein-Barr virus DNA in salivary gland tumors.

1992 ◽  
Vol 95 (6) ◽  
pp. 860-868 ◽  
Author(s):  
SHINICHI TAIRA ◽  
MINORU OKUDA ◽  
TOYORO OSATO ◽  
FUMIO MIZUNO
Keyword(s):  
Salivary Gland ◽  
Epstein Barr Virus ◽  
Salivary Gland Tumors ◽  
Barr Virus ◽  
Epstein Barr

Absence of Epstein-Barr virus encoded RNA and latent membrane protein (LMP1) in salivary gland neoplasms

1999 ◽  
Vol 113 (10) ◽  
pp. 906-908 ◽  
Author(s):  
A. M. Pollock ◽  
M. Toner ◽  
M. McMenamin ◽  
J. Walker ◽  
C. I. Timon
Keyword(s):  
Salivary Gland ◽  
Membrane Protein ◽  
Epstein Barr Virus ◽  
Undifferentiated Carcinoma ◽  
Latent Membrane Protein ◽  
Positive Signal ◽  
Salivary Gland Tumours ◽  
Barr Virus ◽  
Epstein Barr

AbstractA series of 55 (42 benign and 13 malignant) salivary gland tumours were investigated by immunohistochemistry, to detect Epstein-Barr virus (EBV) latent membrane protein (LMP1) and byin situhybridization for EBV-encoded RNA. Non-neoplastic gland from all the patients with tumours and 15 control glands were also examined. All cases, both neoplastic and non-neoplastic were negative for LMP1 and failed to show any positive signal byin situhybridization for EBV RNA. One undifferentiated carcinoma from a European patient was included in the group. These results confirm previous reports of an ethnic association between EBV and undifferentiated carcinomas of the salivary gland. They do not support an aetiological role for EBV in other salivary gland tumours.

scholarly journals Role of Viral Infections in the Pathogenesis of Sjögren’s Syndrome: Different Characteristics of Epstein-Barr Virus and HTLV-1

2020 ◽  
Vol 9 (5) ◽  
pp. 1459 ◽  
Author(s):  
Hideki Nakamura ◽  
Toshimasa Shimizu ◽  
Atsushi Kawakami
Keyword(s):  
Salivary Gland ◽  
Sjögren’S Syndrome ◽  
Epstein Barr Virus ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Cell Leukemia Virus Type ◽  
Barr Virus ◽  
Epstein Barr ◽  
Sjögren‘S Syndrome

Viruses are possible pathogenic agents in several autoimmune diseases. Sjögren’s syndrome (SS), which involves exocrine dysfunction and the appearance of autoantibodies, shows salivary gland- and lacrimal gland-oriented clinical features. Epstein-Barr virus (EBV) is the most investigated pathogen as a candidate that directly induces the phenotype found in SS. The reactivation of the virus with various stimuli induced a dysregulated form of EBV that has the potential to infect SS-specific B cells and plasma cells that are closely associated with the function of an ectopic lymphoid structure that contains a germinal center (GC) in the salivary glands of individuals with SS. The involvement of human T-cell leukemia virus type 1 (HTLV-1) in SS has been epidemiologically established, but the disease concept of HTLV-1-associated SS remains unexplained due to limited evidence from basic research. Unlike the cell-to-cell contact between lymphocytes, biofilm-like structures are candidates as the mode of HTLV-1 infection of salivary gland epithelial cells (SGECs). HTLV-1 can infect SGECs with enhanced levels of inflammatory cytokines and chemokines that are secreted from SGECs. Regardless of the different targets that viruses have with respect to affinitive lymphocytes, viruses are involved in the formation of pathological alterations with immunological modifications in SS.

scholarly journals Prevalence of human papillomavirus and Epstein–Barr virus in salivary gland diseases

2014 ◽  
Vol 42 (5) ◽  
pp. 1093-1101 ◽  
Author(s):  
Frank Cheau-Feng Lin ◽  
Pei-Liang Chen ◽  
Tang-Yi Tsao ◽  
Chia-Ru Li ◽  
Kee-Ching Jeng ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Human Papillomavirus ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Salivary Gland Diseases ◽  
Epstein Barr
Sign in / Sign up

Export Citation Format

Share Document