The Mechanism of Cell Elongation During Lens Fiber Cell Differentiation

1981 ◽  
pp. 79-98 ◽  
Author(s):  
David C. Beebe ◽  
Martha C. Johnson ◽  
Douglas E. Feagans ◽  
Pamela J. Compart
Keyword(s):  
Cell Differentiation ◽  
Cell Elongation ◽  
Fiber Cell ◽  
Lens Fiber ◽  
Lens Fiber Cell

The mechanism of cell elongation during lens fiber cell differentiation

1982 ◽  
Vol 92 (1) ◽  
pp. 54-59 ◽  
Author(s):  
David C. Beebe ◽  
Pamela J. Compart ◽  
Martha C. Johnson ◽  
Douglas E. Feagans ◽  
Richard N. Feinberg
Keyword(s):  
Cell Differentiation ◽  
Cell Elongation ◽  
Fiber Cell ◽  
Lens Fiber ◽  
Lens Fiber Cell

Bone morphogenetic protein signaling and the initiation of lens fiber cell differentiation

Development ◽  
2002 ◽  
Vol 129 (16) ◽  
pp. 3795-3802 ◽  
Author(s):  
Teri Louise Belecky-Adams ◽  
Ruben Adler ◽  
David C. Beebe
Keyword(s):  
Cell Differentiation ◽  
Growth Factor ◽  
Cell Elongation ◽  
Chicken Embryo ◽  
Vitreous Humor ◽  
Fiber Cell ◽  
Lens Fiber ◽  
Lens Fiber Cell ◽  
Fiber Cells ◽  
Bmp Receptors

Previous studies showed that the retina produces factors that promote the differentiation of lens fiber cells, and identified members of the fibroblast growth factor (FGF) and insulin-like growth factor (IGF) families as potential fiber cell differentiation factors. A possible role for the bone morphogenetic proteins (BMPs) is suggested by the presence of BMP receptors in chicken embryo lenses. We have now observed that phosphorylated SMAD1, an indicator of signaling through BMP receptors, localizes to the nuclei of elongating lens fiber cells. Transduction of chicken embryo retinas and/or lenses with constructs expressing noggin, a secreted protein that binds BMPs and prevents their interactions with their receptors, delayed lens fiber cell elongation and increased cell death in the lens epithelium. In an in vitro explant system, in which chicken embryo or adult bovine vitreous humor stimulates chicken embryo lens epithelial cells to elongate into fiber-like cells, these effects were inhibited by noggin-containing conditioned medium, or by recombinant noggin. BMP2, 4, or 7 were able to reverse the inhibition caused by noggin. Lens cell elongation in epithelial explants was stimulated by treatment with FGF1 or FGF2, alone or in combination with BMP2, but not to the same extent as vitreous humor. These data indicate that BMPs participate in the differentiation of lens fiber cells, along with at least one additional, and still unknown factor.

scholarly journals Fibroblast growth factor receptor signaling is essential for lens fiber cell differentiation

2008 ◽  
Vol 318 (2) ◽  
pp. 276-288 ◽  
Author(s):  
Haotian Zhao ◽  
Tianyu Yang ◽  
Bhavani P. Madakashira ◽  
Cornelius A. Thiels ◽  
Chad A. Bechtle ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Fiber Cell ◽  
Fibroblast Growth ◽  
Lens Fiber ◽  
Lens Fiber Cell ◽  
Growth Factor Receptor Signaling

pRb and p107 regulate E2F activity during lens fiber cell differentiation

Oncogene ◽  
1998 ◽  
Vol 16 (3) ◽  
pp. 399-408 ◽  
Author(s):  
Anuradha M Rampalli ◽  
Chun Y Gao ◽  
Vijay M Chauthaiwale ◽  
Peggy S Zelenka
Keyword(s):  
Cell Differentiation ◽  
Fiber Cell ◽  
Lens Fiber ◽  
Lens Fiber Cell

scholarly journals Characterization of small Maf regulators in lens fiber cell differentiation and cataract formation

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Christine Dang ◽  
Smriti A Agrawal ◽  
Stephanie M Waters ◽  
Hozumi Motohashi ◽  
Salil A. Lachke
Keyword(s):  
Cell Differentiation ◽  
Fiber Cell ◽  
Lens Fiber ◽  
Cataract Formation ◽  
Lens Fiber Cell

scholarly journals Increased O-GlcNAc causes disrupted lens fiber cell differentiation and cataracts

2009 ◽  
Vol 387 (1) ◽  
pp. 70-76 ◽  
Author(s):  
Kai Wang ◽  
Shiuh-Rong Ho ◽  
Weiming Mao ◽  
Ping Huang ◽  
Fengxue Zhang ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Fiber Cell ◽  
Lens Fiber ◽  
Lens Fiber Cell

scholarly journals A role for Wnt/planar cell polarity signaling during lens fiber cell differentiation?

2006 ◽  
Vol 17 (6) ◽  
pp. 712-725 ◽  
Author(s):  
Y. Chen ◽  
R.J.W. Stump ◽  
F.J. Lovicu ◽  
J.W. McAvoy
Keyword(s):  
Cell Differentiation ◽  
Cell Polarity ◽  
Planar Cell Polarity ◽  
Fiber Cell ◽  
Lens Fiber ◽  
Lens Fiber Cell
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