Biological Determinants of Host-Parasite Relationship in Mouse Cysticer-Cosis Caused byTaenia crassiceps: Influence of Sex, Major Histocompatibility Complex and Vaccination

1988 ◽  
pp. 325-332
Author(s):  
C. Larralde ◽  
E. Sciutto ◽  
J. Grun ◽  
M. L. Díaz ◽  
T. Govezensky ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
Major Histocompatibility ◽  
Histocompatibility Complex ◽  
Host Parasite Relationship ◽  
Parasite Relationship ◽  
Biological Determinants ◽  
Host Parasite

Detection of host DNA sequences including the H-2 locus of the major histocompatibility complex in schistosomes

Parasitology ◽  
1995 ◽  
Vol 110 (2) ◽  
pp. 163-170 ◽  
Author(s):  
Y. Iwamura ◽  
H. Yonekawa ◽  
Y. Irie
Keyword(s):  
Major Histocompatibility Complex ◽  
Dna Sequences ◽  
Major Histocompatibility ◽  
Male Adult ◽  
Class I Mhc ◽  
Mouse Major Histocompatibility Complex ◽  
Histocompatibility Complex ◽  
Pcr Products ◽  
Primer Sets ◽  
Host Parasite

SUMMARYThe mouse type 2 Alu (B2) sequence was detected in both DNAs of Schistosoma mansoni and S. japonicum except for the cercarial stage by the polymerase chain reaction (PCR). Using several kinds of mouse STMS (sequence tagged microsatellite site) primer sets, PCR products related to the host were found in the DNAs of S. mansoni as well as of S. japonicum. Products could be detected only in the DNA of S. japonicum using certain STMS primer sets. The fact that no products could be amplified from the DNAs of both parasites when other kinds of STMS primer sets were used suggests unequal incorporation of the host DNA into the schistosomes. Furthermore, the sequence of the N-terminal domain of H-2, the mouse major histocompatibility complex (MHC), was detected in the DNAs from S. mansoni miracidium, male adult and S. japonicum adults, whereas the sequence of the C2 domain of H-2 was found only in the DNAs of S. japonicum adults. This evidence that host DNA sequences, including the class I MHC, exist heterogeneously in the DNAs of schistosomes might provide an important insight for further understanding of host-parasite immune interactions.

Relationship of Major Histocompatibility Complex Class II Genes to Inhibitor Antibody Formation in Hemophilia A

1990 ◽  
Vol 64 (04) ◽  
pp. 564-568 ◽  
Author(s):  
Lloyd E Lippert ◽  
Lyman Mc A Fisher ◽  
Lawrence B Schook
Keyword(s):  
Major Histocompatibility Complex ◽  
Factor Viii ◽  
Antibody Formation ◽  
Rflp Analysis ◽  
Class Ii ◽  
Major Histocompatibility ◽  
Odds Ratios ◽  
Inhibitory Antibody ◽  
Histocompatibility Complex ◽  
Hla Dr

SummaryApproximately 14% of transfused hemophiliacs develop an anti-factor VIII inhibitory antibody which specifically neutralizes factor VIII procoagulant activity. In this study an association of the major histocompatibility complex (MHC) with inhibitor antibody formation was evaluated by restriction fragment length polymorphism (RFLP) analysis using BamHI, EcoRI, HindII, PstI, PvuII and TaqI digested genomic DNA probed with DP beta, DQ alpha, DQ beta and DR beta class II MHC gene probes. The RFLP patterns for 16 non-inhibitor and 11 inhibitor hemophiliac patients were analyzed. These 24 enzyme:probe combinations generated 231 fragments. Fifteen (15) fragments associated with the inhibitor phenotype; odds ratios ranged from 5.1 to 45 and lower bounds of 95% confidence intervals were > 1.000 for all 15 fragments. Five (5) fragments associated with non-inhibitors, with odds ratios ranging from 6.4 to 51.7. This report establishes a MHC related genetic basis for the inhibitor phenotype. No statistically significant differences in the distribution of serologically defined HLA-DR phenotypes were observed between the inhibitor and non-inhibitor groups.

Association of susceptibility to spontaneous diabetes in rat with genes of major histocompatibility complex

Diabetes ◽  
1988 ◽  
Vol 37 (10) ◽  
pp. 1438-1443 ◽  
Author(s):  
E. Colle ◽  
S. J. Ono ◽  
A. Fuks ◽  
R. D. Guttmann ◽  
T. A. Seemayer
Keyword(s):  
Major Histocompatibility Complex ◽  
Spontaneous Diabetes ◽  
Major Histocompatibility ◽  
Histocompatibility Complex

Restriction fragment polymorphisms in the major histocompatibility complex of diabetic BB rats

Diabetes ◽  
1984 ◽  
Vol 33 (8) ◽  
pp. 807-809 ◽  
Author(s):  
W. Kastern ◽  
T. Dyrberg ◽  
J. Scholler ◽  
I. Kryspin-Sorensen
Keyword(s):  
Major Histocompatibility Complex ◽  
Restriction Fragment ◽  
Major Histocompatibility ◽  
Histocompatibility Complex ◽  
Bb Rats
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