Glutathione S—transferase and drug resistance

1989 ◽  
pp. 171-187 ◽  
Author(s):  
Lorraine A. Cazenave ◽  
Jeffrey A. Moscow ◽  
Charles E. Myers ◽  
Kenneth H. Cowan
Keyword(s):  
Drug Resistance ◽  
Glutathione S Transferase

scholarly journals Glutathione-S-transferase pi as a determinant of drug resistance in transfectant cell lines.

1990 ◽  
Vol 265 (8) ◽  
pp. 4296-4301
Author(s):  
K Nakagawa ◽  
N Saijo ◽  
S Tsuchida ◽  
M Sakai ◽  
Y Tsunokawa ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Cell Lines ◽  
Glutathione S Transferase

Glutathione S-Transferase Placental Form in Human and Rat Gliomas and Its Possible Role in Drug Resistance

1991 ◽  
pp. 288-294 ◽  
Author(s):  
Akira Hara ◽  
Noboru Sakai ◽  
Shuji Niikawa ◽  
Hiroshi Hirayama ◽  
Hiromu Yamada ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Glutathione S Transferase

scholarly journals The Relationship of Glutathione-S-Transferase and Multi-Drug Resistance-Related Protein 1 in Nitric Oxide (NO) Transport and Storage

Molecules ◽  
2021 ◽  
Vol 26 (19) ◽  
pp. 5784
Author(s):  
Tiffany M. Russell ◽  
Mahan Gholam Azad ◽  
Des R. Richardson
Keyword(s):  
Nitric Oxide ◽  
Drug Resistance ◽  
Ammonia Oxidation ◽  
Iron Complexes ◽  
Physiological Model ◽  
Iron Complex ◽  
Multi Drug Resistance ◽  
Related Protein ◽  
Glutathione S Transferase ◽  
And Storage

Nitric oxide is a diatomic gas that has traditionally been viewed, particularly in the context of chemical fields, as a toxic, pungent gas that is the product of ammonia oxidation. However, nitric oxide has been associated with many biological roles including cell signaling, macrophage cytotoxicity, and vasodilation. More recently, a model for nitric oxide trafficking has been proposed where nitric oxide is regulated in the form of dinitrosyl-dithiol-iron-complexes, which are much less toxic and have a significantly greater half-life than free nitric oxide. Our laboratory has previously examined this hypothesis in tumor cells and has demonstrated that dinitrosyl-dithiol-iron-complexes are transported and stored by multi-drug resistance-related protein 1 and glutathione-S-transferase P1. A crystal structure of a dinitrosyl-dithiol-iron complex with glutathione-S-transferase P1 has been solved that demonstrates that a tyrosine residue in glutathione-S-transferase P1 is responsible for binding dinitrosyl-dithiol-iron-complexes. Considering the roles of nitric oxide in vasodilation and many other processes, a physiological model of nitric oxide transport and storage would be valuable in understanding nitric oxide physiology and pathophysiology.

scholarly journals Glutathione S‐transferase Pi 1 is a valuable predictor for cancer drug resistance in esophageal squamous cell carcinoma

2018 ◽  
Vol 110 (2) ◽  
pp. 795-804 ◽  
Author(s):  
Shinpei Ogino ◽  
Hirotaka Konishi ◽  
Daisuke Ichikawa ◽  
Daiki Matsubara ◽  
Katsutoshi Shoda ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cancer Drug ◽  
Glutathione S Transferase ◽  
Cancer Drug Resistance ◽  
Valuable Predictor

Synovial sarcoma: immunohistochemical expression of p-glycoprotein and glutathione s-transferase-pi and clinical drug resistance

1997 ◽  
Vol 193 (1) ◽  
pp. 21-36 ◽  
Author(s):  
José M. Lopes ◽  
Øyvind S. Bruland ◽  
Bodil Bjerkehagen ◽  
M. Carolina Silva ◽  
Ruth Holm ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Synovial Sarcoma ◽  
Immunohistochemical Expression ◽  
Glutathione S Transferase ◽  
P Glycoprotein ◽  
Clinical Drug

Prognostic effect of drug resistance of glutathione-S-transferase in non small lung cancer

Lung Cancer ◽  
2012 ◽  
Vol 77 ◽  
pp. S21 ◽  
Author(s):  
H. Aziz ◽  
R. Gaafar ◽  
A. Bahnassy ◽  
A. Helal
Keyword(s):  
Lung Cancer ◽  
Drug Resistance ◽  
Glutathione S Transferase ◽  
Prognostic Effect

Rapid development of glutathione-S-transferase-dependent drug resistance in vitro and its prevention by ethacrynic acid

1999 ◽  
Vol 136 (1) ◽  
pp. 47-52 ◽  
Author(s):  
Paula B Caffrey ◽  
Ming Zhu ◽  
Yixin Zhang ◽  
Norihiro Chinen ◽  
Gerald D Frenkel
Keyword(s):  
Drug Resistance ◽  
Ethacrynic Acid ◽  
Rapid Development ◽  
Glutathione S Transferase
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