Estrogen Induced Cathepsin D in Breast Cancer: From Biology to Clinical Applications

1989 ◽  
pp. 171-186 ◽  
Author(s):  
Henri Rochefort ◽  
Patrick Augereau ◽  
Pierre Briozzo ◽  
Jean-Paul Brouillet ◽  
Françoise Capony ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cathepsin D ◽  
Clinical Applications

The estrogen-regulated 52K-cathepsin-D in breast cancer: From biology to clinical applications

1987 ◽  
Vol 14 (4) ◽  
pp. 377-384 ◽  
Author(s):  
Henri Rochefort ◽  
Françoise Capony ◽  
Patrick Augereau ◽  
Vincent Cavailles ◽  
Marcel Garcia ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cathepsin D ◽  
Clinical Applications

Cathepsin D in breast cancer: mechanisms and clinical applications, a 1999 overview

2000 ◽  
Vol 291 (2) ◽  
pp. 157-170 ◽  
Author(s):  
Henri Rochefort ◽  
Marcel Garcia ◽  
Murielle Glondu ◽  
Valérie Laurent ◽  
Emmanuelle Liaudet ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cathepsin D ◽  
Clinical Applications

Clinical applications of circulating tumor DNA in monitoring breast cancer drug resistance

2020 ◽  
Vol 16 (34) ◽  
pp. 2863-2878
Author(s):  
Yang Liu ◽  
Qian Du ◽  
Dan Sun ◽  
Ruiying Han ◽  
Mengmeng Teng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Resistance ◽  
Digital Pcr ◽  
Circulating Tumor Dna ◽  
Resistance Mechanisms ◽  
Clinical Applications ◽  
Current Status ◽  
Cancer Drug ◽  
Genomic Alteration ◽  
Tumor Dna

Breast cancer is one of the leading causes of cancer-related deaths in women worldwide. Unfortunately, treatments often fail because of the development of drug resistance, the underlying mechanisms of which remain unclear. Circulating tumor DNA (ctDNA) is free DNA released into the blood by necrosis, apoptosis or direct secretion by tumor cells. In contrast to repeated, highly invasive tumor biopsies, ctDNA reflects all molecular alterations of tumors dynamically and captures both spatial and temporal tumor heterogeneity. Highly sensitive technologies, including personalized digital PCR and deep sequencing, make it possible to monitor response to therapies, predict drug resistance and tailor treatment regimens by identifying the genomic alteration profile of ctDNA, thereby achieving precision medicine. This review focuses on the current status of ctDNA biology, the technologies used to detect ctDNA and the potential clinical applications of identifying drug resistance mechanisms by detecting tumor-specific genomic alterations in breast cancer.

scholarly journals Reevaluating Cathepsin D as a biomarker for breast cancer: Serum activity levels versus histopathology

2010 ◽  
Vol 9 (1) ◽  
pp. 23-30 ◽  
Author(s):  
Daniel E Abbott ◽  
Naira V Margaryan ◽  
Jacqueline Jeruss ◽  
Seema Khan ◽  
Virginia Kaklamani ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cathepsin D ◽  
Activity Levels ◽  
Serum Activity

Clinical Applications of Circulating Tumor Cells in Breast Cancer

2019 ◽  
pp. 147-160 ◽  
Author(s):  
Erin F. Cobain ◽  
Costanza Paoletti ◽  
Jeffrey B. Smerage ◽  
Daniel F. Hayes
Keyword(s):  
Breast Cancer ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Clinical Applications

Modulation of Cathepsin-D and pS2 Protein Levels in Human Breast Cancer Cell Lines

Tumor Biology ◽  
1996 ◽  
Vol 17 (5) ◽  
pp. 290-298 ◽  
Author(s):  
V. Cappelletti ◽  
L. Fioravanti ◽  
P. Miodini ◽  
G. Di Fronzo
Keyword(s):  
Breast Cancer ◽  
Cell Lines ◽  
Breast Cancer Cell ◽  
Cathepsin D ◽  
Human Breast Cancer ◽  
Human Breast Cancer Cell ◽  
Breast Cancer Cell Lines ◽  
Human Breast ◽  
Protein Levels ◽  
Ps2 Protein

The expression of Cathepsin-D,C-erbB-2 and EGFR in breast cancer and its correlation to lymphatic metastasis

1995 ◽  
Vol 7 (2) ◽  
pp. 97-102
Author(s):  
Liangzhong Xu ◽  
Weiping Zhu ◽  
Taiming Zhang ◽  
Aiping Jing ◽  
Zhenzhou Shen
Keyword(s):  
Breast Cancer ◽  
Lymphatic Metastasis ◽  
Cathepsin D

ENDOCYTOSIS OF THE SECRETED PRO-CATHEPSIN D INTO BREAST CANCER CELLS IS PARTLY INDEPENDENT OF THE MANNOSE-6-PHOSPHATE RECEPTORS

1996 ◽  
Vol 88 (1-2) ◽  
pp. 82-82
Author(s):  
Valérie LAURENT ◽  
Reza FARNOUD ◽  
Annick LUCAS ◽  
Christian ROUGEOT ◽  
Marcel GARCIA ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Cathepsin D ◽  
Breast Cancer Cells ◽  
Mannose 6 Phosphate
Sign in / Sign up

Export Citation Format

Share Document