The expression of Cathepsin-D,C-erbB-2 and EGFR in breast cancer and its correlation to lymphatic metastasis

1995 ◽  
Vol 7 (2) ◽  
pp. 97-102
Author(s):  
Liangzhong Xu ◽  
Weiping Zhu ◽  
Taiming Zhang ◽  
Aiping Jing ◽  
Zhenzhou Shen
Keyword(s):  
Breast Cancer ◽  
Lymphatic Metastasis ◽  
Cathepsin D

scholarly journals Reevaluating Cathepsin D as a biomarker for breast cancer: Serum activity levels versus histopathology

2010 ◽  
Vol 9 (1) ◽  
pp. 23-30 ◽  
Author(s):  
Daniel E Abbott ◽  
Naira V Margaryan ◽  
Jacqueline Jeruss ◽  
Seema Khan ◽  
Virginia Kaklamani ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cathepsin D ◽  
Activity Levels ◽  
Serum Activity

Modulation of Cathepsin-D and pS2 Protein Levels in Human Breast Cancer Cell Lines

Tumor Biology ◽  
1996 ◽  
Vol 17 (5) ◽  
pp. 290-298 ◽  
Author(s):  
V. Cappelletti ◽  
L. Fioravanti ◽  
P. Miodini ◽  
G. Di Fronzo
Keyword(s):  
Breast Cancer ◽  
Cell Lines ◽  
Breast Cancer Cell ◽  
Cathepsin D ◽  
Human Breast Cancer ◽  
Human Breast Cancer Cell ◽  
Breast Cancer Cell Lines ◽  
Human Breast ◽  
Protein Levels ◽  
Ps2 Protein

ENDOCYTOSIS OF THE SECRETED PRO-CATHEPSIN D INTO BREAST CANCER CELLS IS PARTLY INDEPENDENT OF THE MANNOSE-6-PHOSPHATE RECEPTORS

1996 ◽  
Vol 88 (1-2) ◽  
pp. 82-82
Author(s):  
Valérie LAURENT ◽  
Reza FARNOUD ◽  
Annick LUCAS ◽  
Christian ROUGEOT ◽  
Marcel GARCIA ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Cathepsin D ◽  
Breast Cancer Cells ◽  
Mannose 6 Phosphate

Studying Lymphatic Metastasis in Breast Cancer: Current Models, Strategies, and Clinical Perspectives

2020 ◽  
Vol 25 (3) ◽  
pp. 191-203 ◽  
Author(s):  
Briana To ◽  
Daniel Isaac ◽  
Eran R. Andrechek
Keyword(s):  
Breast Cancer ◽  
Lymphatic Metastasis

scholarly journals Large Pore Mesoporous Silica and Organosilica Nanoparticles for Pepstatin A Delivery in Breast Cancer Cells

Molecules ◽  
2019 ◽  
Vol 24 (2) ◽  
pp. 332 ◽  
Author(s):  
Saher Rahmani ◽  
Jelena Budimir ◽  
Mylene Sejalon ◽  
Morgane Daurat ◽  
Dina Aggad ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Cells ◽  
Cathepsin D ◽  
Breast Cancer Cells ◽  
Potent Inhibitor ◽  
Mesoporous Silica Nanoparticles ◽  
Sol Gel ◽  
Pepstatin A

(1) Background: Nanomedicine has recently emerged as a new area of research, particularly to fight cancer. In this field, we were interested in the vectorization of pepstatin A, a peptide which does not cross cell membranes, but which is a potent inhibitor of cathepsin D, an aspartic protease particularly overexpressed in breast cancer. (2) Methods: We studied two kinds of nanoparticles. For pepstatin A delivery, mesoporous silica nanoparticles with large pores (LPMSNs) and hollow organosilica nanoparticles (HOSNPs) obtained through the sol–gel procedure were used. The nanoparticles were loaded with pepstatin A, and then the nanoparticles were incubated with cancer cells. (3) Results: LPMSNs were monodisperse with 100 nm diameter. HOSNPs were more polydisperse with diameters below 100 nm. Good loading capacities were obtained for both types of nanoparticles. The nanoparticles were endocytosed in cancer cells, and HOSNPs led to the best results for cancer cell killing. (4) Conclusions: Mesoporous silica-based nanoparticles with large pores or cavities are promising for nanomedicine applications with peptides.

Cathepsin D in Breast Cancer Tissue

1990 ◽  
Vol 5 (4) ◽  
pp. 203-206 ◽  
Author(s):  
P. Gonzalez Gancedo ◽  
M.L. G-Casaus ◽  
J. Ruiz Cacho ◽  
F. Calero ◽  
J.M. Inocente ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cathepsin D ◽  
Clinical Stage ◽  
Point Of View ◽  
Axillary Lymph Nodes ◽  
Cancer Tissue ◽  
Axillary Lymph ◽  
Statistical Point ◽  
High Concentrations ◽  
Dependent State

The cathepsin D concentration in 18 women with benign breast pathology has a cut-off value of 43 pmol/mg of protein. High values have been detected in two cases of chronic mastitis. These high values of cathepsin D were found in a study of 62 patients suffering from breast cancer and are independent of the hormone dependent state of the tumour. The cathepsin D concentration may have a prognostic function in breast cancer determination, as high concentrations are found in combination with other prognostic factors such as clinical stage, size of the tumour, state of the axillary lymph nodes and in the histological differentiation grade, where from a statistical point of view, the combination is important.

Cathepsin D and Prognosis in Breast Cancer

1990 ◽  
Vol 322 (5) ◽  
pp. 297-302 ◽  
Author(s):  
Atul K. Tandon ◽  
Gary M. Clark ◽  
Gary C. Chamness ◽  
John M. Chirgwin ◽  
William L. McGuire
Keyword(s):  
Breast Cancer ◽  
Cathepsin D

Clinical significance of cathepsin D assay in breast cancer tissues

1995 ◽  
Vol 60 (4) ◽  
pp. 221-226 ◽  
Author(s):  
Yukashi Itoh ◽  
Shunzo Kobayashi ◽  
Hirotaka Iwase ◽  
Hiroko Yamashita ◽  
Tatsuya Kuzushima ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinical Significance ◽  
Cathepsin D ◽  
Cancer Tissues

Abstract P6-14-08: Lucanthone Inhibits Autophagy and Promotes Cathepsin D-Mediated Apoptosis in Breast Cancer Cells

2010 ◽  
Author(s):  
JS Carew ◽  
CM Espitia ◽  
JA Esquivel II ◽  
D Mahalingam ◽  
KR Kelly ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Cathepsin D ◽  
Breast Cancer Cells
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