Manipulation of Early Mammalian Development: What Does It Tell Us about Cell Lineages?

1986 ◽  
pp. 279-296 ◽  
Author(s):  
Martin H. Johnson
Keyword(s):  
Mammalian Development ◽  
Cell Lineages ◽  
Early Mammalian Development

scholarly journals Early mammalian development: from basic research to the clinic

2019 ◽  
Vol 63 (3-4-5) ◽  
pp. 73-75 ◽  
Author(s):  
Aneta Suwińska ◽  
Anna Ajduk
Keyword(s):  
Embryonic Development ◽  
Basic Research ◽  
Embryonic Cell ◽  
Mammalian Development ◽  
Cell Lineages ◽  
Mammalian Embryos ◽  
New Ideas ◽  
Totipotent Cell ◽  
Early Mammalian Development ◽  
Mammalian Embryonic Development

Preimplantation embryonic development lays the foundations for the future individual. Fertilization, cleavage, differentiation of the first embryonic cell lineages and implantation of the embryo into the maternal uterus are absolutely critical for proper embryogenesis. Solving unanswered questions as well as creating new ideas and theories constitute the main axis of the basic research, which is driven by the curiosity of scientists and their desire to explore the unknown. We researchers have been exploring the development of mammalian embryos for decades, searching for the answer to the most fundamental question in the whole area of biology: how a complex organism derives from a single totipotent cell, a zygote. Due to obvious ethical concerns, animals, such as mice and, currently more and more often, cattle, pigs and rabbits, have become useful models for studying human embryonic development. Unprecedented advancement in cell and molecular biology techniques witnessed in the last years allows us to deepen our understanding of mammalian embryonic development.

scholarly journals STAT signaling is active during early mammalian development

1997 ◽  
Vol 208 (2) ◽  
pp. 190-198 ◽  
Author(s):  
Stephen A. Duncan ◽  
Zhong Zhong ◽  
Zilong Wen ◽  
James E. Darnell
Keyword(s):  
Mammalian Development ◽  
Stat Signaling ◽  
Early Mammalian Development

scholarly journals Heat shock proteins and their role in early mammalian development

1997 ◽  
Vol 29 (3) ◽  
pp. 139-150 ◽  
Author(s):  
David A Walsh ◽  
Marshall J Edwards MJ ◽  
Murray SR Smith
Keyword(s):  
Heat Shock ◽  
Heat Shock Proteins ◽  
Mammalian Development ◽  
Shock Proteins ◽  
Early Mammalian Development

scholarly journals Mammalian development does not recapitulate suspected key transformations in the evolution of the mammalian middle ear

2015 ◽  
Author(s):  
Héctor Ramirez-Chaves ◽  
Stephen Wroe ◽  
Lynne Selwood ◽  
Lyn Hinds ◽  
Chris Leigh ◽  
...  
Keyword(s):  
Middle Ear ◽  
Mammalian Development ◽  
Positional Change ◽  
Lower Jaw ◽  
Dental Eruption ◽  
Mesozoic Mammals ◽  
Differential Positioning ◽  
Jaw Joint ◽  
Early Mammalian Development ◽  
Land Vertebrates

The tympanic ring, malleus and incus of the mammalian middle ear (MME) derive from the ancestral primary jaw joint of land vertebrates. In Mesozoic mammals, evolutionary detachment of the MME from the lower jaw occurred when Meckel’s cartilage - the last connection between MME and dentary – disappeared. This disappearance is famously recapitulated in early mammalian development. Further developmental recapitulation of Mesozoic MME detachment is thought to occur in the form of negative allometry and posterior/medial replacement of MME bones relative to the jaw joint. However, despite being widely accepted, such detailed recapitulation scenarios have never been quantified. Here we show, based on µCT scans of developmental series of several marsupials and monotremes, that negative allometry of MME bones relative to the skull occurs only after MME detachment, ruling it out as a developmental detachment trigger; additionally, there is no positional change of ectotympanic or malleus relative to the dentary. Differential positioning of MME bones in the two monotreme species is also not developmentally recapitulated. Our results challenge the developmental prerequisites of widely accepted evolutionary scenarios regarding MME detachment. Rather, we observe an association of MME detachment and dental eruption, suggesting a detachment trigger relating to the onset of dentary function.

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