Monoclonal Antibodies Against Estrogen Receptor: Specificity, Sensitivity and Potential Applications

1985 ◽  
pp. 190-202 ◽  
Author(s):  
K. McCarty ◽  
J. Snowhite ◽  
E. Cox ◽  
L. Miller ◽  
K. McCarty
Keyword(s):  
Estrogen Receptor ◽  
Monoclonal Antibodies ◽  
Receptor Specificity ◽  
Potential Applications

Monoclonal antibodies demonstrate multiple forms of estrogen receptor in ovarian adenocarcinomas

1985 ◽  
Vol 20 (2) ◽  
pp. 270 ◽  
Author(s):  
J.A. Holt ◽  
M.A. Lorincz ◽  
G.L. Greene ◽  
A.L. Herbst
Keyword(s):  
Estrogen Receptor ◽  
Monoclonal Antibodies ◽  
Multiple Forms ◽  
Ovarian Adenocarcinomas

Interaction of Three Monoclonal Antibodies with the Nonactivated and Activated Forms of the Estrogen Receptor*

Endocrinology ◽  
1990 ◽  
Vol 126 (3) ◽  
pp. 1403-1409 ◽  
Author(s):  
NORA GIAMBIAGI ◽  
JORGE R. PASQUALINI
Keyword(s):  
Estrogen Receptor ◽  
Monoclonal Antibodies

scholarly journals Monoclonal antibodies reveal receptor specificity among G-protein-coupled receptor kinases.

1996 ◽  
Vol 93 (15) ◽  
pp. 7649-7654 ◽  
Author(s):  
M. Oppermann ◽  
M. Diverse-Pierluissi ◽  
M. H. Drazner ◽  
S. L. Dyer ◽  
N. J. Freedman ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
G Protein ◽  
G Protein Coupled Receptor ◽  
Receptor Specificity ◽  
Receptor Kinases ◽  
G Protein Coupled

scholarly journals Microtiter plate immunoenzymometric assay for estrogen receptor

1996 ◽  
Vol 42 (12) ◽  
pp. 1955-1960 ◽  
Author(s):  
V Delage ◽  
J M Teulon ◽  
L Bellanger ◽  
P Seguin ◽  
F Descotes ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Monoclonal Antibodies ◽  
Microtiter Plate ◽  
Breast Adenocarcinoma ◽  
Comparison Study ◽  
Clinical Specimens ◽  
Microtiter Plates ◽  
Two Samples ◽  
Er Status

Abstract The estrogen receptor (ER) status of breast cancer is used both as a prognostic factor and as a predictor of response to endocrine therapy. An immunoenzymometric assay for ER was developed on 96-well microtiter plates (EIA96). This technique involves two monoclonal antibodies directed against different epitopes in the B domain of ER. The two-step protocol (16-18 h and 3 h at 4 degrees C) requires 100 microL of cytosol. This assay showed a detection limit of 0.58 pmol/L. Intra- and interassay CVs of clinical specimens were < or = 5% except for the least concentrated sample (6.5 pmol/L, CV = 6.7%). In a comparison study involving cytosols of breast adenocarcinoma tissue biopsies, we compared the EIA96 with the radioligand assay (RLA) and the Abbott ER-EIA, widely used techniques for determining ER concentration in cytosols of breast cancer tumors. The two EIAs showed excellent agreement; however, two samples showed discrepant results by EIA96 and RLA.

Comparison of immunohistochemical analysis with estrogen receptor SP1 and 1D5 monoclonal antibodies in breast cancer

2012 ◽  
Vol 208 (11) ◽  
pp. 657-661 ◽  
Author(s):  
Klesia Pirola Madeira ◽  
Renata Dalmaschio Daltoé ◽  
Gabriela Modenesi Sirtoli ◽  
Lucas Cunha Dias de Rezende ◽  
Alex Assis de Carvalho ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Monoclonal Antibodies ◽  
Immunohistochemical Analysis

scholarly journals A Comparison of Estrogen Receptor SP1 and 1D5 Monoclonal Antibodies in Routine Clinical Use Reveals Similar Staining Results

2009 ◽  
Vol 132 (3) ◽  
pp. 396-401 ◽  
Author(s):  
Jane E. Brock ◽  
Jason L. Hornick ◽  
Andrea L. Richardson ◽  
Deborah A. Dillon ◽  
Susan C. Lester
Keyword(s):  
Estrogen Receptor ◽  
Monoclonal Antibodies ◽  
Clinical Use
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