Role of the Vitamin D System in the Pathogenesis of Renal Osteodystrophy

Metabolic Bone Disease in the CAPD Patient

Peritoneal Dialysis International ◽

10.1177/089686088300301s08 ◽

1983 ◽

Vol 3 (1_suppl) ◽

pp. 24-26 ◽

Cited By ~ 3

Author(s):

Francisco Llach

Keyword(s):

Vitamin D ◽

Renal Osteodystrophy ◽

Bone Disease ◽

Metabolic Bone Disease ◽

Osteitis Fibrosa ◽

Prospective Evaluation ◽

Metabolic Bone ◽

Capd Patient

It seems that CAPD may improve some patients with osteomalacia but may be similar to hemodialysis in regard to osteitis fibrosa. However, long-term prospective evaluation of the incidence of bone disease in CAPD patients is necessary before we can determine how CAPD may alter the incidence and expression of renal osteodystrophy. We need more information before we can conclude that CAPD may improve pure osteomalacia. Finally, the data available are insufficient to clarify the role of vitamin D analogues in these patients.

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The Pathogenesis of Renal Osteodystrophy: Role of Vitamin D, Aluminium, Parathyroid Hormone, Calcium and Phosphorus

QJM ◽

10.1093/oxfordjournals.qjmed.a067861 ◽

1985 ◽

Keyword(s):

Vitamin D ◽

Parathyroid Hormone ◽

Renal Osteodystrophy ◽

Calcium And Phosphorus

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Renal Osteodystrophy in Children: The Role of Vitamin D, Phosphorus, and Parathyroid Hormone

American Journal of Kidney Diseases ◽

10.1016/s0272-6386(86)80068-3 ◽

1986 ◽

Vol 7 (4) ◽

pp. 275-284 ◽

Cited By ~ 13

Author(s):

Russell W. Chesney ◽

Otto Mehls ◽

Constantine S. Anast ◽

Edward Brown ◽

Marc R. Hammerman ◽

...

Keyword(s):

Vitamin D ◽

Parathyroid Hormone ◽

Renal Osteodystrophy

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VITAMIN D IN HEALTH AND DISEASE: Role of Parathyroid Hormone and Therapy with Active Vitamin D Sterols in Renal Osteodystrophy

Seminars in Dialysis ◽

10.1111/j.1525-139x.2005.18404.x ◽

2005 ◽

Vol 18 (4) ◽

pp. 290-295 ◽

Cited By ~ 16

Author(s):

Joel D. Hernandez ◽

Katherine Wesseling ◽

Isidro B. Salusky

Keyword(s):

Vitamin D ◽

Parathyroid Hormone ◽

Renal Osteodystrophy ◽

Active Vitamin ◽

Active Vitamin D ◽

Health And Disease ◽

Active Vitamin D Sterols

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The role of vitamin D in metabolic and reproductive disturbances of polycystic ovary syndrome: A narrative mini-review

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000691 ◽

2020 ◽

pp. 1-8

Author(s):

Daniela Menichini ◽

Gianpiero Forte ◽

Beatrice Orrù ◽

Giuseppe Gullo ◽

Vittorio Unfer ◽

...

Keyword(s):

Vitamin D ◽

Polycystic Ovary Syndrome ◽

Embryo Quality ◽

Polycystic Ovary ◽

Vitamin D Supplementation ◽

Endometrial Receptivity ◽

Metabolic Disturbances ◽

Ovary Syndrome ◽

Beneficial Role

Abstract. Vitamin D is a secosteroid hormone that plays a pivotal role in several metabolic and reproductive pathways in humans. Increasing evidence supports the role of vitamin D deficiency in metabolic disturbances and infertility in women with polycystic ovary syndrome (PCOS). Indeed, supplementation with vitamin D seems to have a beneficial role on insulin resistance and endometrial receptivity. On the other hand, exceedingly high levels of vitamin D appear to play a detrimental role on oocytes development and embryo quality. In the current review, we summarize the available evidence about the topic, aiming to suggest the best supplementation strategy in women with PCOS or, more generally, in those with metabolic disturbances and infertility. Based on the retrieved data, vitamin D seems to have a beneficial role on IR, insulin sensitivity and endometrial receptivity, but high levels and incorrect timing of administration seem to have a detrimental role on oocytes development and embryo quality. Therefore, we encourage a low dose supplementation (400–800 IU/day) particularly in vitamin D deficient women that present metabolic disturbances like PCOS. As far as the reproductive health, we advise vitamin D supplementation in selected populations, only during specific moments of the ovarian cycle, to support the luteal phase. However, ambiguities about dosage and timing of the supplementation still emerge from the clinical studies published to date and further studies are required.

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