T Lymphocyte Recognition of Small Peptide Antigens: Formation of Neoantigenic Determinants and Clonal Frequency Resulting in IR Gene Control

1983 ◽  
pp. 247-259
Author(s):  
David W. Thomas ◽  
Michael D. Hoffman ◽  
Kun-hwa Hsieh ◽  
George D. Wilner
Keyword(s):  
T Lymphocyte ◽  
Gene Control ◽  
Small Peptide ◽  
Peptide Antigens

Effective Priming of Cytotoxic T Lymphocyte Precursors by Subcutaneous Administration of Peptide Antigens in Liposomes Accompanied by Anti-CD40 and Anti-CTLA-4 Antibodies

Immunobiology ◽  
2000 ◽  
Vol 201 (5) ◽  
pp. 527-540 ◽  
Author(s):  
Daisuke Ito ◽  
Kazumasa Ogasawara ◽  
Kazuhiro Matsushita ◽  
Taiki Morohashi ◽  
Kenichi Namba ◽  
...  
Keyword(s):  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Subcutaneous Administration ◽  
Peptide Antigens

scholarly journals Genetic control of cytolytic T-lymphocyte responses. I. Ir gene control of the specificity of cytolytic T-lymphocyte responses to trinitrophenyl-modified syngeneic cells.

1978 ◽  
Vol 148 (2) ◽  
pp. 341-350 ◽  
Author(s):  
P Billings ◽  
S J Burakoff ◽  
M E Dorf ◽  
B Benacerraf
Keyword(s):  
T Lymphocyte ◽  
Inbred Mouse ◽  
Cross Reactivity ◽  
Mouse Strains ◽  
Gene Control ◽  
F1 Hybrid ◽  
Cytolytic T Lymphocyte ◽  
Lymphocyte Responses ◽  
Hybrid Mice

The ability of cytotoxic T lymphocytes (CTL) induced in vitro to trinitrophenyl (TNP)-modified syngeneic cells to cross-reactively lyse a TNP allogeneic spleen target varies among inbred mouse strains. The cross-reactive CTL phenotype was found to be histocompatibility 2 (H-2) linked and to be dominant in F1 hybrid mice. All strains investigated demonstrated cross-reactivity except for some strains bearing portions of the H-2k haplotype. The gene(s) controlling this response maps to the K and/or I-A region of the H-2 complex. We have termed the immune response (Ir) gene responsible for controlling the specificity of CTL induced to TNP-modified syngeneic cells Ir-X-TNP.

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