Phenotypic Switching and Var Gene Transcription in Plasmodium Falciparum

2003 ◽  
pp. 149-159 ◽  
Author(s):  
Rintis Noviyanti ◽  
Graham V. Brown
Keyword(s):  
Plasmodium Falciparum ◽  
Gene Transcription ◽  
Phenotypic Switching ◽  
Var Gene

scholarly journals Differential var gene transcription in Plasmodium falciparum isolates from patients with cerebral malaria compared to hyperparasitaemia

2006 ◽  
Vol 150 (2) ◽  
pp. 211-218 ◽  
Author(s):  
Helen M. Kyriacou ◽  
Graham N. Stone ◽  
Richard J. Challis ◽  
Ahmed Raza ◽  
Kirsten E. Lyke ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Cerebral Malaria ◽  
Gene Transcription ◽  
Var Gene

The Plasmodium falciparum var gene transcription strategy at the onset of blood stage infection in a human volunteer

2009 ◽  
Vol 58 (4) ◽  
pp. 478-480 ◽  
Author(s):  
Christian W. Wang ◽  
Cornelus C. Hermsen ◽  
Robert W. Sauerwein ◽  
David E. Arnot ◽  
Thor G. Theander ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Gene Transcription ◽  
Blood Stage ◽  
Human Volunteer ◽  
Blood Stage Infection ◽  
Stage Infection ◽  
Var Gene

scholarly journals In Vitro Variant Surface Antigen Expression in Plasmodium falciparum Parasites from a Semi-Immune Individual Is Not Correlated with Var Gene Transcription

PLoS ONE ◽  
2016 ◽  
Vol 11 (12) ◽  
pp. e0166135 ◽  
Author(s):  
Ellen Inga Bruske ◽  
Sandra Dimonte ◽  
Corinna Enderes ◽  
Serena Tschan ◽  
Matthias Flötenmeyer ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Gene Transcription ◽  
Surface Antigen ◽  
Antigen Expression ◽  
Variant Surface Antigen ◽  
Surface Antigen Expression ◽  
Var Gene ◽  
Immune Individual

var gene transcription dynamics in Plasmodium falciparum patient isolates

2010 ◽  
Vol 170 (2) ◽  
pp. 74-83 ◽  
Author(s):  
Karin Blomqvist ◽  
Johan Normark ◽  
Daniel Nilsson ◽  
Ulf Ribacke ◽  
Judy Orikiriza ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Gene Transcription ◽  
Var Gene

scholarly journals var gene transcription and PfEMP1 expression in the rosetting and cytoadhesive Plasmodium falciparum clone FCR3S1.2

2011 ◽  
Vol 10 (1) ◽  
pp. 17 ◽  
Author(s):  
Letusa Albrecht ◽  
Kirsten Moll ◽  
Karin Blomqvist ◽  
Johan Normark ◽  
Qijun Chen ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Gene Transcription ◽  
Var Gene

scholarly journals A distinct 5' flanking var gene region regulates Plasmodium falciparum variant erythrocyte surface antigen expression in placental malaria

2002 ◽  
Vol 45 (1) ◽  
pp. 155-167 ◽  
Author(s):  
Aleida Vazquez-Macias ◽  
Perla Martinez-Cruz ◽  
Maria Cristina Castaneda-Patlan ◽  
Christine Scheidig ◽  
Jurg Gysin ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Surface Antigen ◽  
Placental Malaria ◽  
Antigen Expression ◽  
Gene Region ◽  
Erythrocyte Surface ◽  
Surface Antigen Expression ◽  
Var Gene

scholarly journals DETECTION SENSITIVITY AND QUANTITATION OF PLASMODIUM FALCIPARUM VAR GENE TRANSCRIPTS BY REAL-TIME RT-PCR IN COMPARISON WITH CONVENTIONAL RT-PCR

2006 ◽  
Vol 75 (2) ◽  
pp. 212-218 ◽  
Author(s):  
MICHELLE L. GATTON ◽  
ELIZABETH V. FOWLER ◽  
KARRYN GRESTY ◽  
QIN CHENG ◽  
NANHUA CHEN ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Real Time ◽  
Detection Sensitivity ◽  
Rt Pcr ◽  
Gene Transcripts ◽  
Var Gene

scholarly journals The Plasmodium falciparum var gene switching rate, switching mechanism and patterns of parasite recrudescence described by mathematical modelling

Parasitology ◽  
2002 ◽  
Vol 124 (3) ◽  
pp. 225-235 ◽  
Author(s):  
S. PAGET-MCNICOL ◽  
M. GATTON ◽  
I. HASTINGS ◽  
A. SAUL
Keyword(s):  
Plasmodium Falciparum ◽  
Chronic Infection ◽  
Malaria Parasite ◽  
Gene Repertoire ◽  
Switching Rate ◽  
Specific Immunity ◽  
Parasite Survival ◽  
Gene Switching ◽  
Variant Antigen ◽  
Var Gene

Recrudescing Plasmodium falciparum parasitaemia is attributed to the switching of PfEMP1, a variant antigen family encoded by the var gene repertoire, and the host's immune response. We have developed a mathematical model which incorporates var gene switching, and variant specific, non-variant specific and non-specific immunity. By conducting a sensitivity analysis of the model we have defined the parameter limits which produce chronic and recrudescing infections. We explore 3 switching mechanisms: ordered, random and uncoupled switching. We show that if var genes switch on and off independently at variable rates through the repertoire a chronic clinical infection is predicted. The fastest switching-on rate that produces a chronic infection is 0·03% per generation. The model predicts that non-variant specific immunity plays an important role in reducing disease severity. This work illustrates the complex relationship between the malaria parasite and its host and shows that var gene switching at rates substantially slower than 2% are essential for parasite survival.

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