Decreased activity of lecithin:cholesterol acyltransferase and hepatic lipase in chronic hypothyroid rats: Implications for reverse cholesterol transport

2003 ◽  
pp. 51-56
Author(s):  
Martha Franco ◽  
Graciela Castro ◽  
Luis Romero ◽  
Juan Carlos Regalado ◽  
Claudia Huesca-Gómez ◽  
...  
Keyword(s):  
Reverse Cholesterol Transport ◽  
Hepatic Lipase ◽  
Cholesterol Transport ◽  
Lecithin:Cholesterol Acyltransferase

Effect of sardine proteins on hyperglycaemia, hyperlipidaemia and lecithin:cholesterol acyltransferase activity, in high-fat diet-induced type 2 diabetic rats

2015 ◽  
Vol 115 (1) ◽  
pp. 6-13 ◽  
Author(s):  
Nora Benaicheta ◽  
Fatima Z. Labbaci ◽  
Malika Bouchenak ◽  
Farida O. Boukortt
Keyword(s):  
Insulin Sensitivity ◽  
High Fat Diet ◽  
Reverse Cholesterol Transport ◽  
Serum Insulin ◽  
Diabetic Rats ◽  
Cholesterol Transport ◽  
Lcat Activity ◽  
Lecithin:Cholesterol Acyltransferase ◽  
High Fat

AbstractType 2 diabetes (T2D) is a major risk factor of CVD. The effects of purified sardine proteins (SP) were examined on glycaemia, insulin sensitivity and reverse cholesterol transport in T2D rats. Rats fed a high-fat diet (HFD) for 5 weeks, and injected with a low dose of streptozotocin, were used. The diabetic rats were divided into four groups, and they were fed casein (CAS) or SP combined with 30 or 5 % lipids, for 4 weeks. HFD-induced hyperglycaemia, insulin resistance and hyperlipidaemia in rats fed HFD, regardless of the consumed protein. In contrast, these parameters lowered in rats fed SP combined with 5 or 30 % lipids, and serum insulin values reduced in SP v. CAS. HFD significantly increased total cholesterol and TAG concentrations in the liver and serum, whereas these parameters decreased with SP, regardless of lipid intake. Faecal cholesterol excretion was higher with SP v. CAS, combined with 30 or 5 % lipids. Lecithin:cholesterol acyltransferase (LCAT) activity and HDL3-phospholipids (PL) were higher in CAS-HF than in CAS, whereas HDL2-cholesteryl esters (CE) were lower. Otherwise, LCAT activity and HDL2-CE were higher in the SP group than in the CAS group, whereas HDL3-PL and HDL3-unesterified cholesterol were lower. Moreover, LCAT activity lowered in the SP-HF group than in the CAS-HF group, when HDL2-CE was higher. In conclusion, these results indicate the potential effects of SP to improve glycaemia, insulin sensitivity and reverse cholesterol transport, in T2D rats.

Reverse Cholesterol Transport in Plasma of Patients With Different Forms of Familial HDL Deficiency

1995 ◽  
Vol 15 (5) ◽  
pp. 691-703 ◽  
Author(s):  
Arnold von Eckardstein ◽  
Yadong Huang ◽  
Shili Wu ◽  
Harald Funke ◽  
Giorgio Noseda ◽  
...  
Keyword(s):  
Reverse Cholesterol Transport ◽  
Cholesterol Transport

Smoking prevents the intravascular remodeling of high-density lipoprotein particles: implications for reverse cholesterol transport

Metabolism ◽  
2004 ◽  
Vol 53 (7) ◽  
pp. 858-862 ◽  
Author(s):  
Águeda C.M Zaratin ◽  
Eder C.R Quintão ◽  
Andrei C Sposito ◽  
Valéria S Nunes ◽  
Ana Maria Lottenberg ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
Reverse Cholesterol Transport ◽  
Density Lipoprotein ◽  
High Density ◽  
Cholesterol Transport ◽  
Lipoprotein Particles
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