Fulminant Myocarditis—From Lethal Disease to Survival

2003 ◽  
pp. 159-169
Author(s):  
Tohru Izumi ◽  
Naoyoshi Aoyama ◽  
Mototsugu Nishii ◽  
Hitoshi Takehana ◽  
Chieko Matsuda ◽  
...  
Keyword(s):  
Fulminant Myocarditis

Clinical and Morphological Features of Myocardial Damage and the Course of Fulminant Myocarditis on the Background of СOVID-19, Diagnosis and Treatment Tactics

2020 ◽  
Vol 75 (5S) ◽  
pp. 414-425
Author(s):  
Olga S. Oynotkinova ◽  
Evgenii L. Nikonov ◽  
Oleg V. Zayratyants ◽  
Elena V. Rzhevskaya ◽  
Evgenii V. Krukov ◽  
...  
Keyword(s):  
Myocardial Dysfunction ◽  
Myocardial Damage ◽  
Heart Rhythm ◽  
Microvascular Dysfunction ◽  
Symptomatic Treatment ◽  
Clinical Situation ◽  
Diagnosis And Treatment ◽  
Screening Tests ◽  
Fulminant Myocarditis ◽  
Heart Rhythm Disorders

In a review article based on my own clinical experience of managing patients with acute myocardial injury and fulminant myocarditis, taking into account expert recommendations on the clinical treatment of myocardial damage associated with novel coronavirus infection a National clinical geriatric medical research center, division of cardiovascular diseases, the Chinese geriatrics society, Department of cardiology, Beijing Medical Association and European clinics discusses the pathogenesis, diagnosis and treatment of myocardial damage and FM patients, infected with SARS-CoV-2 in the context of the COVID-19 pandemic. Clinical features and diagnostic criteria are presented, including screening tests of markers of myocardial damage in the form of a highly sensitive troponin test, a natriuretic peptide. The article discusses in detail the pathogenesis and mechanisms of myocardial damage, including immune mechanisms, cytokine storm, systemic inflammation with macro- and microvascular dysfunction and the development of myocardial dysfunction with acute heart failure, hypotension, cardiogenic shock and/or life-threatening heart rhythm disorders caused by hypoxia and metabolic disorders at the cellular level. Features of the clinical course of fulminant myocarditis in infected patients (SARS-CoV-2) in the conditions of the COVID-19 pandemic are presented. For the first time, a detailed histo-morphological analysis of pathological myocardial injuries and complications is presented on the basis of unique autopsy material on post-mortem diagnostics of various pathoanatomic autopsies of those who died from COVID-19 in Moscow. Based on the clinical, functional and morphological material, the Protocol of etiopathogenetic treatment is presented. The basis of standard therapy is considered antiviral drugs, immunoglobulin G, the use of monoclonal antibodies to interleukin-6, anticoagulants, glucocorticoids, depending on the clinical situation, cardioprotectors and symptomatic treatment are recommended to maintain the heart, which in combination can achieve a certain clinical effectiveness. As adjuvant cardioprotective targeted therapy, the sodium salt of phosphocreatine is considered in order to preserve the myocardium, maintain its contractility and vital activity.

scholarly journals A Case of Recurrent Fulminant Myocarditis in a Short Time

2016 ◽  
Vol 22 (9) ◽  
pp. S220
Author(s):  
Yutaka Yamagishi ◽  
Mutsuko Takata ◽  
Toshinori Higashikata ◽  
Tomoya Kaneda ◽  
Ryusuke Yamamoto ◽  
...  
Keyword(s):  
Fulminant Myocarditis ◽  
Short Time

scholarly journals FULMINANT MYOCARDITIS DUE TO ARBOVIRUS INFECTION

2021 ◽  
Vol 77 (18) ◽  
pp. 699
Author(s):  
Karina Auristela Gonzalez Carta ◽  
Ivan Mendoza Britto ◽  
Igoor Morr ◽  
Yolimar Meza ◽  
Elias Urbaez ◽  
...  
Keyword(s):  
Fulminant Myocarditis ◽  
Arbovirus Infection

scholarly journals Complement C9 expression is associated with damaged myocardial cells in pediatric sudden death cases of fulminant myocarditis

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Akari Takaya Uno ◽  
Masahito Hitosugi ◽  
Mami Nakamura ◽  
Tomoyuki Nakanishi ◽  
Takahiro Mima ◽  
...  
Keyword(s):  
Sudden Death ◽  
Acute Myocarditis ◽  
Lymphocytic Infiltration ◽  
Pericardial Fluid ◽  
Sirtuin 1 ◽  
Fulminant Myocarditis ◽  
Myocardial Cells ◽  
Hematoxylin And Eosin ◽  
Hematoxylin And Eosin Staining ◽  
Complement C9

Abstract Background Because disease progression is so fast in sudden death of acute fulminant myocarditis, damage of myocardial cells is not evident in routine hematoxylin and eosin staining. To understand damage to myocardial cells and the mechanism of sudden death, immunohistochemical staining was performed for two forensic autopsy cases. Case presentation The patients were a healthy 5-year-old girl and 8-year-old boy. They suddenly died within 2 days of appearance of flu-like symptoms. An autopsy showed accumulation of yellowish-clear pericardial fluid containing fibrin deposits, fluid blood in the heart, and congestion of visceral organs. Histologically, minor necrosis or degeneration of myocardial cells with mainly lymphocytic infiltration was observed sometimes in tissue sections. Immunohistochemically, positive complement C9 staining and negative sirtuin 1 staining were found. These findings suggested wide damage of myocardial cells, even in regions with no marked changes in myocardial cells with hematoxylin and eosin staining. These areas corresponded to those with strong accumulation of lymphocytes. Conclusions Immunohistochemistry for complement C9 and sirtuin 1 might become a new tool for evaluating damage of myocardial cells of fulminant acute myocarditis.

scholarly journals NEAR-DEATH AND BACK IN 10 DAYS: AN UNEXPECTED CASE OF SARS-COV-2 FULMINANT MYOCARDITIS

2021 ◽  
Vol 77 (18) ◽  
pp. 2980
Author(s):  
Yetunde A. Fatade ◽  
Franck Azobou Tonleu ◽  
Avery Calhoun ◽  
Mariana Garcia ◽  
Tuoyo Mene-Afejuku ◽  
...  
Keyword(s):  
Fulminant Myocarditis

scholarly journals FULMINANT MYOCARDITIS AND MULTISYSTEM INFLAMMATORY SYNDROME IN CHILDREN, IN THE LIGHT OF CORONA VIRUS

2021 ◽  
Vol 77 (18) ◽  
pp. 1964
Author(s):  
Vijay Pratap Singh ◽  
Mousa Thalji ◽  
Swaiman Singh ◽  
Hamza Hafeez ◽  
Amandeep Sekhon ◽  
...  
Keyword(s):  
Fulminant Myocarditis ◽  
Corona Virus ◽  
Inflammatory Syndrome

scholarly journals CARDIOGENIC SHOCK, WORSENED BY FULMINANT MYOCARDITIS OR PACING-INDUCED CARDIOMYOPATHY?

2021 ◽  
Vol 77 (18) ◽  
pp. 2277
Author(s):  
Nicholas J. Campbell ◽  
Kimberly O’ Dell ◽  
Abdul-Razaq Adeniyi ◽  
Patrick Stevens
Keyword(s):  
Cardiogenic Shock ◽  
Fulminant Myocarditis

Ventricular Tachycardia in Acute Fulminant Myocarditis: Medical Management and Follow-up

2007 ◽  
Vol 29 (2) ◽  
pp. 416-419 ◽  
Author(s):  
J. R. Sharma ◽  
S. Sathanandam ◽  
S. P. Rao ◽  
S. Acharya ◽  
V. Flood
Keyword(s):  
Ventricular Tachycardia ◽  
Medical Management ◽  
Fulminant Myocarditis
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