Gene Therapy for Cerebrovascular Disease and Central Nervous System Trauma

2001 ◽  
pp. 201-223
Author(s):  
R. Loch Macdonald
Keyword(s):  
Gene Therapy ◽  
Central Nervous System ◽  
Nervous System ◽  
Cerebrovascular Disease ◽  
Central Nervous System Trauma

scholarly journals Treating Complex Nervous System Vascular Disorders through a “Needle Stick”: Origins, Evolution, and Future of Neuroendovascular Therapy

Neurosurgery ◽  
2001 ◽  
Vol 48 (3) ◽  
pp. 463-475 ◽  
Author(s):  
L. Nelson Hopkins ◽  
Giuseppe Lanzino ◽  
Lee R. Guterman
Keyword(s):  
Gene Therapy ◽  
Central Nervous System ◽  
Nervous System ◽  
Molecular Basis ◽  
Nervous System Diseases ◽  
Central Nervous System Diseases ◽  
Biological Factors ◽  
Device Development ◽  
The Past ◽  
Established Treatment

Abstract IN THE PAST few decades, dramatic improvements have occurred in the field of neuroendovascular surgery. Endovascular therapy today is a well-established treatment modality for a variety of cerebrovascular and nonvascular central nervous system diseases. The foundation of this spectacular evolution was laid by the efforts of pioneering visionaries who often worked alone and under difficult, almost impossible, conditions. Ongoing device development and refinement have revolutionized the field at a dizzying, exhilarating pace. With a better understanding of the molecular basis of diseases and further advancements in gene therapy, neuroendovascular techniques have an enormous potential for application to the entire spectrum of central nervous system diseases as a minimally invasive vehicle for the delivery of biological factors.

Capsid-Engineering for Central Nervous System-Directed Gene Therapy with Adeno-Associated Virus Vectors

2021 ◽  
Vol 32 (19-20) ◽  
pp. 1096-1119
Author(s):  
Josephine Macdonald ◽  
Jennifer Marx ◽  
Hildegard Büning
Keyword(s):  
Gene Therapy ◽  
Central Nervous System ◽  
Nervous System ◽  
Adeno Associated Virus ◽  
Virus Vectors

2-(Aminomethyl)chromans that inhibit iron-dependent lipid peroxidation and protect against central nervous system trauma and ischemia

1992 ◽  
Vol 35 (23) ◽  
pp. 4464-4472 ◽  
Author(s):  
E. Jon Jacobsen ◽  
Fred J. VanDoornik ◽  
Donald E. Ayer ◽  
Kenneth L. Belonga ◽  
J. Mark Braughler ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Central Nervous System ◽  
Nervous System ◽  
Central Nervous System Trauma
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