Alkylation of Purine Bases by Carbon-Centered Radicals

Author(s):  
Jae O. Kang
Keyword(s):  
2019 ◽  
Vol 8 (4) ◽  
pp. 263-278
Author(s):  
Józef Mazurkiewicz ◽  
Piotr Tomasik ◽  
Wojciech Ciesielski

Author(s):  
Michal Hocek ◽  
Peter Šilhár ◽  
Martin Kuchař ◽  
Zbyněk Hasník ◽  
Vítězslav Bambuch

1910 ◽  
Vol 8 (5) ◽  
pp. 385-393
Author(s):  
Oswald Schreiner ◽  
Edmund C. Shorey

1980 ◽  
Vol 53 (5) ◽  
pp. 1252-1256 ◽  
Author(s):  
Hiroaki Ohya-Nishiguchi ◽  
Yasunori Shimizu ◽  
Noboru Hirota ◽  
Kohji Watanabe

2005 ◽  
Vol 127 (37) ◽  
pp. 12758-12759 ◽  
Author(s):  
Ji-ang Liu ◽  
Christopher J. Petzold ◽  
Luis E. Ramirez-Arizmendi ◽  
James Perez ◽  
Hilkka Kenttämaa

1993 ◽  
Vol 58 (6) ◽  
pp. 1419-1429 ◽  
Author(s):  
Hana Dvořáková ◽  
Antonín Holý

Analogs of antiviral 9-(2-phosphonomethoxyethyl)adenine (PMEA,II), containing modified purine bases 1-deazaadenine (VII, 3-deazapurine (XI), 7-deaza-7-cyanoadenine (XIIIb) and 3-deazaguanine (XXIb) were prepared by alkylation of the heterocyclic bases with bis(2-propyl) 2-chloroethoxymethylphosphonate (V) in dimethylformamide in the presence of sodium hydride or cesium carbonate. The obtained protected derivatives were deblocked with bromotrimethylsilane to give the phosphonic acids. 3-DeazaPMEG (XXIb) is active against DNA viruses and exhibits a marked cytostatic effect against L-1210 leukemia.


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