Efficacy of the Combined Treatment with Fluconazole and Thymosin α 1 Against Candida albicans Infection in Morphine-Treated Mice

1993 ◽  
pp. 189-194
Author(s):  
Paolo Di Francesco ◽  
Roberta Gaziano ◽  
Francesca Pica ◽  
Ida Casalinuovo ◽  
Anna Teresa Palamara ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Combined Treatment ◽  
Candida Albicans Infection

THE INFLUENCE OF WHOLE SONICATE BRUCELLA ABORTUS ANTIGEN ON THE CANDIDA ALBICANS INFECTION IN MICE

2009 ◽  
Vol 8 (1) ◽  
pp. 48-59
Author(s):  
A M.J ◽  
A S.S ◽  
A I.A ◽  
A Al-Oubaidy ◽  
A Alwan ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Brucella Abortus ◽  
Candida Albicans Infection

scholarly journals The Negative Effect of Protein Phosphatase Z1 Deletion on the Oxidative Stress Tolerance of Candida albicans Is Synergistic with Betamethasone Exposure

2021 ◽  
Vol 7 (7) ◽  
pp. 540
Author(s):  
Ágnes Jakab ◽  
Tamás Emri ◽  
Kinga Csillag ◽  
Anita Szabó ◽  
Fruzsina Nagy ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Candida Albicans ◽  
Protein Phosphatase ◽  
Combined Treatment ◽  
Specific Protein ◽  
Ergosterol Biosynthesis ◽  
Acid Oxidation ◽  
Menadione Sodium Bisulfite ◽  
Rnaseq Data ◽  
Negative Effect

The glucocorticoid betamethasone (BM) has potent anti-inflammatory and immunosuppressive effects; however, it increases the susceptibility of patients to superficial Candida infections. Previously we found that this disadvantageous side effect can be counteracted by menadione sodium bisulfite (MSB) induced oxidative stress treatment. The fungus specific protein phosphatase Z1 (CaPpz1) has a pivotal role in oxidative stress response of Candida albicans and was proposed as a potential antifungal drug target. The aim of this study was to investigate the combined effects of CaPPZ1 gene deletion and MSB treatment in BM pre-treated C. albicans cultures. We found that the combined treatment increased redox imbalance, enhanced the specific activities of antioxidant enzymes, and reduced the growth in cappz1 mutant (KO) strain. RNASeq data demonstrated that the presence of BM markedly elevated the number of differentially expressed genes in the MSB treated KO cultures. Accumulation of reactive oxygen species, increased iron content and fatty acid oxidation, as well as the inhibiting ergosterol biosynthesis and RNA metabolic processes explain, at least in part, the fungistatic effect caused by the combined stress exposure. We suggest that the synergism between MSB treatment and CaPpz1 inhibition could be considered in developing of a novel combinatorial antifungal strategy accompanying steroid therapy.

scholarly journals CD137 Signaling Is Critical in Fungal Clearance during Systemic Candida albicans Infection

2021 ◽  
Vol 7 (5) ◽  
pp. 382
Author(s):  
Vuvi G. Tran ◽  
Na N. Z. Nguyen ◽  
Byungsuk Kwon
Keyword(s):  
Candida Albicans ◽  
Defense Mechanisms ◽  
Tumor Necrosis ◽  
Fungal Infections ◽  
Fungal Growth ◽  
Wild Type ◽  
Agonistic Antibody ◽  
Innate Defense ◽  
Surface Receptor ◽  
Candida Albicans Infection

Invasive fungal infections by Candida albicans frequently cause mortality in immunocompromised patients. Neutrophils are particularly important for fungal clearance during systemic C. albican infection, yet little has been known regarding which surface receptor controls neutrophils’ antifungal activities. CD137, which is encoded by Tnfrsf9, belongs to the tumor necrosis receptor superfamily and has been shown to regulate neutrophils in Gram-positive bacterial infection. Here, we used genetic and immunological tools to probe the involvement of neutrophil CD137 signaling in innate defense mechanisms against systemic C. albicans infection. We first found that Tnfrsf9−/− mice were susceptible to C. albicans infection, whereas injection of anti-CD137 agonistic antibody protected the host from infection, suggesting that CD137 signaling is indispensable for innate immunity against C. albicans infection. Priming of isolated neutrophils with anti-CD137 antibody promoted their phagocytic and fungicidal activities through phospholipase C. In addition, injection of anti-CD137 antibody significantly augmented restriction of fungal growth in Tnfrsf9−/− mice that received wild-type (WT) neutrophils. In conclusion, our results demonstrate that CD137 signaling contributes to defense mechanisms against systemic C. albicans infection by promoting rapid fungal clearance.

Suppression of humoral response during the course of Candida albicans infection in mice

1984 ◽  
Vol 88 (1) ◽  
pp. 61-63 ◽  
Author(s):  
Juan Carlos Valdez ◽  
Oscar Enrique Meson ◽  
Graciela Aciar de Valdez ◽  
Angel Sirena
Keyword(s):  
Candida Albicans ◽  
Humoral Response ◽  
Candida Albicans Infection

Elimination of Candida albicans Infection of the Radicular Dentin by Intracanal Medications

2003 ◽  
Vol 29 (8) ◽  
pp. 501-504 ◽  
Author(s):  
J SIQUEIRAJR ◽  
I ROCAS ◽  
H LOPES ◽  
F MAGALHAES ◽  
M DEUZEDA
Keyword(s):  
Candida Albicans ◽  
Candida Albicans Infection

scholarly journals Protective effect of a muramyl dipeptide analog encapsulated in or mixed with liposomes against Candida albicans infection.

1983 ◽  
Vol 39 (1) ◽  
pp. 172-178 ◽  
Author(s):  
E B Fraser-Smith ◽  
D A Eppstein ◽  
M A Larsen ◽  
T R Matthews
Keyword(s):  
Candida Albicans ◽  
Protective Effect ◽  
Muramyl Dipeptide ◽  
Candida Albicans Infection

Evaluation of Ag containing hydroxyapatite coatings to the Candida albicans infection

2016 ◽  
Vol 125 ◽  
pp. 12-18 ◽  
Author(s):  
S. Ciuca ◽  
M. Badea ◽  
E. Pozna ◽  
I. Pana ◽  
A. Kiss ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Hydroxyapatite Coatings ◽  
Candida Albicans Infection
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