Principles of Pharmacokinetic Modeling and Dosimetry

1997 ◽  
pp. 123-149
Author(s):  
Douglas J. Crawford-Brown
Keyword(s):  
Pharmacokinetic Modeling

Pharmacokinetic Modeling in Nano-formulations: Concept, Implementation and Challenges

2019 ◽  
Vol 24 (43) ◽  
pp. 5175-5180 ◽  
Author(s):  
Jatinder Kaur Mukker ◽  
Ravi Shankar Prasad Singh
Keyword(s):  
Drug Delivery ◽  
Modeling And Simulation ◽  
Small Molecules ◽  
Pharmacokinetic Modeling ◽  
Simulation Techniques ◽  
Modeling Techniques

The properties of nanoparticles can be exploited to overcome challenges in drug delivery. By virtue of its design and size, the pharmacokinetics of nanoparticles are different than other small molecules. Modeling and simulation techniques have great potential to be used in nanoformulation development; however, their use in optimization of nanoformulation is very limited. This review highlights the differences in absorption, distribution, metabolism and excretion (ADME) characteristics of nanoparticles, use of modeling and simulation techniques in nanoformulation development and challenges in the implementation of modeling techniques.

Population Pharmacokinetic Modeling of Etoposide Free Concentrations in Solid Tumor

2016 ◽  
Vol 33 (7) ◽  
pp. 1657-1670 ◽  
Author(s):  
Maiara Cássia Pigatto ◽  
Bibiana Verlindo de Araujo ◽  
Bruna Gaelzer Silva Torres ◽  
Stephan Schmidt ◽  
Paolo Magni ◽  
...  
Keyword(s):  
Solid Tumor ◽  
Pharmacokinetic Modeling ◽  
Population Pharmacokinetic ◽  
Population Pharmacokinetic Modeling
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