A Public Policy Design Strategy for Alzheimer’s Disease

1987 ◽  
pp. 363-369
Author(s):  
Woods Bowman
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Public Policy ◽  
Policy Design ◽  
Design Strategy

Minimalistic Design Approach for Multi-Reactivity against Free Radicals and Metal-Free and Metal-Bound Amyloid-β Peptides: Redox-Based Substitutions of Benzene

2019 ◽  
Author(s):  
Mingeun Kim ◽  
Juhye Kang ◽  
Misun Lee ◽  
Jiyeon Han ◽  
Geewoo Nam ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Free Radicals ◽  
Amyloid Β ◽  
Design Strategy ◽  
Design Approach ◽  
Metal Free

We report a minimalistic redox-based design strategy for engineering compact molecules based on the simplest aromatic framework, benzene, with multi-reactivity against free radicals, metal-free amyloid-β, and metal-bound amyloid-β, implicated in the most common form of dementia, Alzheimer’s disease.

scholarly journals Multitarget drug design strategy in Alzheimer's disease: focus on cholinergic transmission and amyloid-β aggregation

2017 ◽  
Vol 9 (10) ◽  
pp. 953-963 ◽  
Author(s):  
Elena Simoni ◽  
Manuela Bartolini ◽  
Izuddin F Abu ◽  
Alix Blockley ◽  
Cecilia Gotti ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Drug Design ◽  
Amyloid Β ◽  
Design Strategy ◽  
Cholinergic Transmission ◽  
Disease Focus

Multi-Target-Directed Drug Design Strategy: From a Dual Binding Site Acetylcholinesterase Inhibitor to a Trifunctional Compound against Alzheimer’s Disease

2007 ◽  
Vol 50 (26) ◽  
pp. 6446-6449 ◽  
Author(s):  
Maria Laura Bolognesi ◽  
Andrea Cavalli ◽  
Luca Valgimigli ◽  
Manuela Bartolini ◽  
Michela Rosini ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Drug Design ◽  
Binding Site ◽  
Acetylcholinesterase Inhibitor ◽  
Design Strategy
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