Effect of Scorpion Toxins on Sodium Channels

1983 ◽  
pp. 273-280 ◽  
Author(s):  
Hans Meves
Keyword(s):  
Sodium Channels ◽  
Scorpion Toxins

scholarly journals Investigation of Binding Modes and Functional Surface of Scorpion Toxins ANEP to Sodium Channels 1.7

Toxins ◽  
2017 ◽  
Vol 9 (12) ◽  
pp. 387 ◽  
Author(s):  
Yongbo Song ◽  
Zeyu Liu ◽  
Qi Zhang ◽  
Chunming Li ◽  
Wei Jin ◽  
...  
Keyword(s):  
Sodium Channels ◽  
Binding Modes ◽  
Scorpion Toxins ◽  
Functional Surface

Functional Anatomy of Scorpion Toxins Affecting Sodium Channels

1998 ◽  
Vol 17 (2) ◽  
pp. 131-159 ◽  
Author(s):  
Dalia Gordon ◽  
Philippe Savarin ◽  
Michael Gurevitz ◽  
Sophie Zinn-Justin
Keyword(s):  
Sodium Channels ◽  
Functional Anatomy ◽  
Scorpion Toxins

Novel paradigms on scorpion toxins that affects the activating mechanism of sodium channels

Toxicon ◽  
2007 ◽  
Vol 49 (2) ◽  
pp. 171-180 ◽  
Author(s):  
Ricardo C. Rodríguez de la Vega ◽  
Lourival D. Possani
Keyword(s):  
Sodium Channels ◽  
Scorpion Toxins

Differential sensitivity of sodium channels from the central and peripheral nervous system to the scorpion toxins Lqh-2 and Lqh-3

2002 ◽  
Vol 16 (4) ◽  
pp. 767-770 ◽  
Author(s):  
◽  
SongQing Lu ◽  
Enrico Leipold ◽  
Dalia Gordon ◽  
Alfred Hansel ◽  
...  
Keyword(s):  
Nervous System ◽  
Peripheral Nervous System ◽  
Sodium Channels ◽  
Differential Sensitivity ◽  
Scorpion Toxins

scholarly journals Subtype Specificity of β-Toxin Tf1a from Tityus fasciolatus in Voltage Gated Sodium Channels

Toxins ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 339 ◽  
Author(s):  
Daniel Mata ◽  
Diogo Tibery ◽  
Leandro Campos ◽  
Thalita Camargos ◽  
Steve Peigneur ◽  
...  
Keyword(s):  
Sodium Channels ◽  
Complex Mixture ◽  
Normal Function ◽  
Structural Function ◽  
Scorpion Toxins ◽  
Voltage Gated ◽  
Voltage Gated Sodium Channels ◽  
Subtype Specificity ◽  
Nav Channels ◽  
Predictive Strength

Scorpion venoms are a complex mixture of components. Among them the most important are peptides, which presents the capacity to interact and modulate several ion channel subtypes, including voltage-gated sodium channels (NaV). Screening the activity of scorpion toxins on different subtypes of NaV reveals the scope of modulatory activity and, in most cases, low channel selectivity. Until now there are approximately 60 scorpion toxins experimentally assayed on NaV channels. However, the molecular bases of interaction between scorpion toxins and NaV channels are not fully elucidated. The activity description of new scorpion toxins is crucial to enhance the predictive strength of the structural–function correlations of these NaV modulatory molecules. In the present work a new scorpion toxin (Tf1a) was purified from Tityus fasciolatus venom by RP-HPLC, and characterized using electrophysiological experiments on different types of voltage-gated sodium channels. Tf1a was able to modify the normal function of NaV tested, showing to be a typical β-NaScTx. Tf1a also demonstrated an unusual capability to alter the kinetics of NaV1.5.

scholarly journals Scorpion Toxins Affecting Sodium Current Inactivation Bind to Distinct Homologous Receptor Sites on Rat Brain and Insect Sodium Channels

1996 ◽  
Vol 271 (14) ◽  
pp. 8034-8045 ◽  
Author(s):  
Dalia Gordon ◽  
Marie-France Martin-Eauclaire ◽  
Sandrine Cestèle ◽  
Charles Kopeyan ◽  
Edmond Carlier ◽  
...  
Keyword(s):  
Rat Brain ◽  
Sodium Channels ◽  
Sodium Current ◽  
Scorpion Toxins ◽  
Receptor Sites

Alpha scorpion toxins binding on rat brain and insect sodium channels reveal divergent allosteric modulations by brevetoxin and veratridine

Toxicon ◽  
1996 ◽  
Vol 34 (3) ◽  
pp. 303-304
Author(s):  
S. Cestele ◽  
R.B. Khalifa ◽  
M. Pelhate ◽  
H. Rochat ◽  
D. Gordon
Keyword(s):  
Rat Brain ◽  
Sodium Channels ◽  
Scorpion Toxins

Alpha scorpion toxins as tools for the study of homologous receptor sites in neuronal sodium channels

Toxicon ◽  
1995 ◽  
Vol 33 (3) ◽  
pp. 268
Author(s):  
D. Gordon ◽  
M.-F. Martin-Eauclaire ◽  
S. Cestele ◽  
Ch. Kopeyan ◽  
E. Zoltkin ◽  
...  
Keyword(s):  
Sodium Channels ◽  
Scorpion Toxins ◽  
Receptor Sites
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