Free Radical Mechanisms of DNA Base Damage

1986 ◽  
pp. 39-49 ◽  
Author(s):  
Michael G. Simic ◽  
Slobodan V. Jovanovic
Keyword(s):  
Free Radical ◽  
Base Damage ◽  
Dna Base

scholarly journals Ne-22 Ion-Beam Radiation Damage to DNA: From Initial Free Radical Formation to Resulting DNA-Base Damage

ACS Omega ◽  
2021 ◽  
Author(s):  
Melis Kant ◽  
Pawel Jaruga ◽  
Erdem Coskun ◽  
Samuel Ward ◽  
Alexander D. Stark ◽  
...  
Keyword(s):  
Free Radical ◽  
Radiation Damage ◽  
Ion Beam ◽  
Radical Formation ◽  
Beam Radiation ◽  
Base Damage ◽  
Dna Base ◽  
Free Radical Formation

scholarly journals Oxidative DNA base damage and antioxidant enzyme levels in childhood acute lymphoblastic leukemia

FEBS Letters ◽  
1997 ◽  
Vol 416 (3) ◽  
pp. 286-290 ◽  
Author(s):  
Sema Sentürker ◽  
Bensu Karahalil ◽  
Mine Inal ◽  
Hülya Yilmaz ◽  
Hamza Müslümanoglu ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Antioxidant Enzyme ◽  
Lymphoblastic Leukemia ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Base Damage ◽  
Dna Base

Free Radical-Induced Tandem Base Damage in DNA Oligomers

1997 ◽  
Vol 23 (7) ◽  
pp. 1021-1030 ◽  
Author(s):  
Harold C Box ◽  
Edwin E Budzinski ◽  
Jean B Dawidzik ◽  
Jason S Gobey ◽  
Harold G Freund
Keyword(s):  
Free Radical ◽  
Base Damage ◽  
Dna Oligomers

DNA base damage in mammalian chromatin by hydrogen peroxide/ferric and cupric ions

1990 ◽  
Vol 9 ◽  
pp. 49 ◽  
Author(s):  
Miral Dizdaroglu ◽  
Govind Rao ◽  
Barry Halliwell ◽  
Ewa Gajewski
Keyword(s):  
Hydrogen Peroxide ◽  
Base Damage ◽  
Dna Base

scholarly journals Oxidative DNA base modifications as factors in carcinogenesis.

1998 ◽  
Vol 45 (2) ◽  
pp. 561-572 ◽  
Author(s):  
R Olinski ◽  
P Jaruga ◽  
T H Zastawny
Keyword(s):  
Metastatic Potential ◽  
Base Damage ◽  
Normal Tissues ◽  
Dna Base ◽  
Dna Modifications ◽  
Cancer Initiation ◽  
Base Modifications ◽  
Therapeutic Doses ◽  
Oxidative Base Damage

Reactive oxygen species can cause extensive DNA modifications including modified bases. Some of the DNA base damage has been found to possess premutagenic properties. Therefore, if not repaired, it can contribute to carcinogenesis. We have found elevated amounts of modified bases in cancerous and precancerous tissues as compared with normal tissues. Most of the agents used in anticancer therapy are paradoxically responsible for induction of secondary malignancies and some of them may generate free radicals. The results of our experiments provide evidence that exposure of cancer patients to therapeutic doses of ionizing radiation and anticancer drugs causes base modifications in genomic DNA of lymphocytes. Some of these base damages could lead to mutagenesis in critical genes and ultimately to secondary cancers such as leukemias. This may point to an important role of oxidative base damage in cancer initiation. Alternatively, the increased level of the modified base products may contribute to genetic instability and metastatic potential of tumor cells.

SPECIFIC DNA BASE DAMAGE PRODUCED BY IRRADIATION OF HYDRATED DNA

1991 ◽  
pp. 403 ◽  
Author(s):  
S.G. SWARTS ◽  
M.D. SEVILLA ◽  
K.T. WHEELER
Keyword(s):  
Base Damage ◽  
Dna Base

DNA base damage by β-lactam, tetracycline, bacitracin and rifamycin antibacterial antibiotics

1991 ◽  
Vol 42 (8) ◽  
pp. 1595-1599 ◽  
Author(s):  
Gregory J. Quinlan ◽  
John M.C. Gutteridge
Keyword(s):  
Base Damage ◽  
Dna Base

Abstract 1496: Oxidatively induced DNA base damage in colorectal carcinoma

2010 ◽  
Author(s):  
Guldal Kirkali ◽  
Didem Keles ◽  
Aras Emre Canda ◽  
Cem Terzi ◽  
Pawel Jaruga ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Base Damage ◽  
Dna Base

Study of the Ability of Lutein and Neoxanthin as Standards and in the Extract of Chlamydomonas reinhardtii to Prevent Oxidatively Induced DNA Base Damage Using Ultrasensitive GC–MS/MS Analysis

2020 ◽  
Vol 83 (8) ◽  
pp. 919-926
Author(s):  
Saliha Şahin ◽  
Önder Aybastıer ◽  
Sam Dawbaa ◽  
Büşra Karkar ◽  
Turgay Çakmak
Keyword(s):  
Chlamydomonas Reinhardtii ◽  
Base Damage ◽  
Ms Analysis ◽  
Dna Base
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