The Role of Eicosanoids in Human Glomerular Disease

1989 ◽  
pp. 389-421
Author(s):  
Alessandro Pierucci ◽  
Giulio Alberto Cinotti
Keyword(s):  
Glomerular Disease

scholarly journals The Beneficial Role of Retinoids in Glomerular Disease

2015 ◽  
Vol 2 ◽  
Author(s):  
Sandeep K. Mallipattu ◽  
John Cijiang He
Keyword(s):  
Glomerular Disease ◽  
Beneficial Role

The role of cell cycle proteins in Glomerular disease

2003 ◽  
Vol 23 (6) ◽  
pp. 569-582 ◽  
Author(s):  
Siân V Griffin ◽  
Raimund Pichler ◽  
Takehiko Wada ◽  
Michael Vaughan ◽  
Raghu Durvasula ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Glomerular Disease ◽  
Cell Cycle Proteins

scholarly journals The Evolving Role of Novel Biomarkers in Glomerular Disease: A Review

2021 ◽  
Vol 77 (1) ◽  
pp. 122-131
Author(s):  
Corey Cavanaugh ◽  
Mark D. Okusa
Keyword(s):  
Glomerular Disease ◽  
Novel Biomarkers

scholarly journals TRPC6 channels and their binding partners in podocytes: role in glomerular filtration and pathophysiology

2010 ◽  
Vol 299 (4) ◽  
pp. F689-F701 ◽  
Author(s):  
Stuart E. Dryer ◽  
Jochen Reiser
Keyword(s):  
Cell Biology ◽  
Transient Receptor Potential ◽  
Receptor Potential ◽  
Glomerular Disease ◽  
Slit Diaphragm ◽  
Trpc Channels ◽  
Structural Elements ◽  
Signaling Dynamics ◽  
Transient Receptor

Loss or dysfunction of podocytes is a major cause of glomerular kidney disease. Several genetic forms of glomerular disease are caused by mutations in genes that encode structural elements of the slit diaphragm or the underlying cytoskeleton of podocyte foot processes. The recent discovery that gain-of-function mutations in Ca2+-permeable canonical transient receptor potential-6 channels (TRPC6) underlie a subset of familial forms of focal segmental glomerulosclerosis (FSGS) has focused attention on the basic cellular physiology of podocytes. Several recent studies have examined the role of Ca2+ dynamics in normal podocyte function and their possible contributions to glomerular disease. This review summarizes the properties of TRPC6 and related channels, focusing on their permeation and gating properties, the nature of mutations associated with familial FSGS, and the role of TRPC channels in podocyte cell biology as well as in glomerular pathophysiology. TRPC6 interacts with several proteins in podocytes, including essential slit diaphragm proteins and mechanosensitive large-conductance Ca2+-activated K+ channels. The signaling dynamics controlling ion channel function and localization in podocytes appear to be quite complex.

scholarly journals COVID-19 and renal involvement; evolving role of thromboinflammation, vascular and glomerular disease in the pathogenesis

2021 ◽  
Vol 10 (3) ◽  
pp. e23-e23
Author(s):  
Tella Sadighpour ◽  
Muhammed Mubarak ◽  
Parastoo Sabaeifard ◽  
Sanam Saeifar ◽  
Fatemeh Kenari
Keyword(s):  
Renal Involvement ◽  
Glomerular Disease
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