Neuronal Degeneration after Intracerebral Injections of Excitotoxins. A Histological Analysis of Kainic Acid, Ibotenic Acid and Quinolinic Acid Lesions in the Rat Brain

Excitotoxins ◽  
1983 ◽  
pp. 99-111 ◽  
Author(s):  
Christer Köhler
Keyword(s):  
Rat Brain ◽  
Kainic Acid ◽  
Quinolinic Acid ◽  
Histological Analysis ◽  
Neuronal Degeneration ◽  
Ibotenic Acid

Dietary supplementation with α-tocopherol reduces neuroinflammation and neuronal degeneration in the rat brain after kainic acid-induced status epilepticus

2011 ◽  
Vol 45 (10) ◽  
pp. 1136-1142 ◽  
Author(s):  
Michele Betti ◽  
Andrea Minelli ◽  
Patrizia Ambrogini ◽  
Stefano Ciuffoli ◽  
Valentina Viola ◽  
...  
Keyword(s):  
Status Epilepticus ◽  
Rat Brain ◽  
Kainic Acid ◽  
Neuronal Degeneration ◽  
Dietary Supplementation

Scavenger receptor mRNAs in rat brain microglia are induced by kainic acid lesioning and by cytokines

Neuroreport ◽  
1997 ◽  
Vol 8 (5) ◽  
pp. 1077-1081 ◽  
Author(s):  
Raji P. Grewal ◽  
Toru Yoshida ◽  
Caleb E. Finch ◽  
Todd E. Morgan
Keyword(s):  
Rat Brain ◽  
Kainic Acid ◽  
Scavenger Receptor ◽  
Receptor Mrnas

Automated Quantification and Simulation of Hippocampal Images Treated with Kainic Acid from Rat Brain Slices

2021 ◽  
Author(s):  
Hussain Saad Alzahrani ◽  
Faruque Reza ◽  
Tahamina Begum ◽  
Aidy Irman Yajid ◽  
Nazlahshaniza Shafin ◽  
...  
Keyword(s):  
Rat Brain ◽  
Kainic Acid ◽  
Brain Slices ◽  
Automated Quantification

STUDIES OF QUINOLINIC ACID METABOLISM IN RAT BRAIN

1984 ◽  
Vol 7 ◽  
pp. S247 ◽  
Author(s):  
R. Schwarcz ◽  
A. C. Foster
Keyword(s):  
Rat Brain ◽  
Quinolinic Acid ◽  
Acid Metabolism

Increased quinolinic acid metabolism following neuronal degeneration in the rat hippocampus

1987 ◽  
Vol 436 (1) ◽  
pp. 18-24 ◽  
Author(s):  
Carmela Speciale ◽  
Etsuo Okuno ◽  
Robert Schwarcz
Keyword(s):  
Quinolinic Acid ◽  
Acid Metabolism ◽  
Neuronal Degeneration ◽  
Rat Hippocampus

The Effect of Aluminum on Rat Brain and Liver Quinolinic Acid Concentrations

1991 ◽  
pp. 459-462
Author(s):  
J. H. Connick ◽  
G. Lombardi ◽  
F. Moroni ◽  
E. Hall ◽  
A. Taylor ◽  
...  
Keyword(s):  
Rat Brain ◽  
Quinolinic Acid ◽  
Rat Brain And Liver

scholarly journals Rab7 Reduces α-Synuclein Toxicity in Rats and Primary Neurons

2021 ◽  
Author(s):  
Éva M. Szegõ ◽  
Eva M. Szegö ◽  
Chris Van den Haute ◽  
Lennart Höfs ◽  
Veerle Baekelandt ◽  
...  
Keyword(s):  
Dna Damage ◽  
Rat Brain ◽  
Neuronal Degeneration ◽  
Degradation Pathway ◽  
Alpha Synuclein ◽  
Dominant Negative ◽  
Primary Neurons ◽  
Vicious Cycle ◽  
Axon Terminals

Abstract BackgroundDuring the pathogenesis of Parkinson’s disease (PD), aggregation of alpha-synuclein (αSyn) induces a vicious cycle of cellular impairments that lead to neurodegeneration. Consequently, removing toxic αSyn aggregates constitutes a plausible strategy against PD. In this work, we tested whether stimulating the autolysosomal degradation of αSyn aggregates through the Ras-related in brain 7 (Rab7) pathway can reverse αSyn-induced cellular impairment and prevent neurodegeneration in vivo.MethodsThe disease-related A53T mutant of αSyn was expressed in primary neurons and in dopaminergic neurons of the rat brain simultaneously with wild type (WT) Rab7 or its dominant-negative T22N mutant as a control. The cellular integrity was quantified by morphological and biochemical analyses.ResultsIn primary neurons, WT Rab7 rescued the αSyn -induced loss of neurons and neurites. Furthermore, Rab7 decreased the amount of reactive oxygen species and the amount of Triton X-100 insoluble αSyn. In rat brain, WT Rab7 reduced αSyn -induced loss of dopaminergic axon terminals in the striatum and the loss of dopaminergic dendrites in the substantia nigra pars reticulata. Further, WT Rab7 lowered αSyn pathology as quantified by phosphorylated αSyn staining. Finally, WT Rab7 attenuated αSyn-induced DNA damage in primary neurons and rat brain.ConclusionRab7 reduced αSyn-induced pathology, ameliorated αSyn-induced neuronal degeneration, oxidative stress and DNA damage. These findings indicate that Rab7 is able to disrupt the vicious cycle of cellular impairment, αSyn pathology and neurodegeneration present in PD. Stimulation of Rab7 and the autolysosomal degradation pathway could therefore constitute a beneficial strategy for PD.

Role of Phosphatidylinositol-3 Kinase Pathway in NMDA Preconditioning: Different Mechanisms for Seizures and Hippocampal Neuronal Degeneration Induced by Quinolinic Acid

2018 ◽  
Vol 34 (3) ◽  
pp. 452-462 ◽  
Author(s):  
Leandra C. Constantino ◽  
Luisa B. Binder ◽  
Samuel Vandresen-Filho ◽  
Giordano G. Viola ◽  
Fabiana K. Ludka ◽  
...  
Keyword(s):  
Quinolinic Acid ◽  
Neuronal Degeneration ◽  
Phosphatidylinositol 3 Kinase ◽  
Nmda Preconditioning ◽  
Kinase Pathway ◽  
Phosphatidylinositol 3
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