Role of Reactive Oxygen Species and Lipid Peroxidation in Chemically Induced Toxicity and Carcinogenesis

1988 ◽  
pp. 157-166
Author(s):  
Martyn T. Smith
Keyword(s):  
Reactive Oxygen Species ◽  
Lipid Peroxidation ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Chemically Induced

scholarly journals Antioxidant effect of Mn2+ on capacitation and acrosome reaction of fresh and chilled cattle bull semen

2012 ◽  
Vol 1 (1) ◽  
pp. 18
Author(s):  
Amrit Kaur Bansal ◽  
Ranjna Sundhey Cheema ◽  
Vinod Kumar Gandotra
Keyword(s):  
Reactive Oxygen Species ◽  
Lipid Peroxidation ◽  
Acrosome Reaction ◽  
Reactive Oxygen ◽  
Antioxidant Effect ◽  
Oxygen Species ◽  
Sperm Capacitation ◽  
Bull Semen

The aim of this paper was to investigate the antioxidant effect of Mn2+ (200 mM) on the sperm capacitation and acrosome reaction of fresh and chilled cattle bull semen. It has been found that Mn2+ supplementation improves (P≤0.05) the motility at 0, 2, 4 and 6 h of incubation. MDA (malondialdehyde), end product of lipid peroxidation, decreases significantly (P≤0.05) with the supplementation of manganese at 0- and 6-hr of incubation both in fresh and chilled semen. Manganese also increases acrosome reaction significantly (P≤0.05) both in fresh and chilled semen at 0, 4 and 6 h of incubation. Therefore, our findings suggest the role of Mn2+supplementation in improving the quality of cattle bull semen by its scavenging property<em> i.e.</em> reduction in the production of reactive oxygen species during its storage at 4°C or incubation at 37°C for capacitation.

Free radicals, lipid peroxidation and sperm function

1995 ◽  
Vol 7 (4) ◽  
pp. 659 ◽  
Author(s):  
RJ Aitken
Keyword(s):  
Reactive Oxygen Species ◽  
Lipid Peroxidation ◽  
Reactive Oxygen ◽  
Human Spermatozoa ◽  
Sperm Function ◽  
Oxygen Species ◽  
Normal Sperm ◽  
Oxidative Processes ◽  
Mammalian Spermatozoa

The cellular generation of reactive oxygen species was first observed in mammalian spermatozoa in the late 1940s. The field then remained dormant for 30 years until Thaddeus Mann and Roy Jones published a series of landmark papers in the 1970s in which the importance of lipid peroxidation as a mechanism for damaging mammalian spermatozoa was first intimated. The subsequent demonstration that human spermatozoa produce reactive oxygen species and are susceptible to peroxidative damage has triggered intense interest in the role of oxidative stress in the aetiology of male infertility. Moreover, data have recently been obtained to indicate that, although excessive exposure to reactive oxygen species may be harmful to spermatozoa, in physiological amounts these molecules are of importance in the control of normal sperm function. This review considers the dualistic role of reactive oxygen species and sets out the current understanding of the importance of oxidative processes in both the physiology and the pathology of the human spermatozoon. Extra keywords: human spermatozoa, reactive oxygen species.

Effects of silicon on plant resistance to environmental stresses: review

2013 ◽  
Vol 27 (2) ◽  
pp. 225-232 ◽  
Author(s):  
T. Balakhnina ◽  
A. Borkowska
Keyword(s):  
Reactive Oxygen Species ◽  
Lipid Peroxidation ◽  
Plant Resistance ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Guaiacol Peroxidase ◽  
Oxygen Species ◽  
Abiotic Stressors ◽  
Activity Of Enzymes

Abstract The role of exogenous silicon in enhancing plant resistance to various abiotic stressors: salinity, drought, metal toxicities and ultraviolet radiation are presented. The data on possible involvement of silicon in reducing the reactive oxygen species generation, intensity of lipid peroxidation, and in some cases, increasing the activity of enzymes of the reactive oxygen species detoxificators: superoxide dismutase, ascorbate peroxidase, glutathione reductase, guaiacol peroxidase and catalase are analyzed.

scholarly journals Malondialdehyde as a Prognostic Marker in Patients with Ovarian Adenocarcinoma

2019 ◽  
Vol 70 (7) ◽  
pp. 2561-2565
Author(s):  
Oana Trifanescu ◽  
Maria Iuliana Gruia ◽  
Laurentia Gales ◽  
Raluca Trifanescu ◽  
Alina Mihaela Pascu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Lipid Peroxidation ◽  
Genetic Instability ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Invasion And Metastasis ◽  
Prognostic Role ◽  
Ovarian Adenocarcinoma

Oxidative stress is defined as the imbalance between reactive oxygen species and cellular antioxidative mechanisms. Reactive oxygen species are involved in the development and progression of many cancers and has been showed to activate pro-tumorigenic signalling, increase tumour cell survival, proliferation, invasion and metastasis, DNA damage and genetic instability. These are highly reactive and attack various classes of essentials biomolecules such as proteins, DNA and most important lipids. Malondialdehyde is the best investigated product of lipid peroxidation. The aim of this study was to evaluate the prognostic role of malondialdehyde in patients with ovarian adenocarcinoma and in an experimental model.

Sign in / Sign up

Export Citation Format

Share Document