Ia Gene Expression in Non-Bone Marrow Derived Cells During Graft Vs Host Disease in the Mouse

H-2 Antigens ◽  
1987 ◽  
pp. 559-569
Author(s):  
P. Michael Stuart ◽  
Jerold G. Woodward
Keyword(s):  
Gene Expression ◽  
Bone Marrow ◽  
Host Disease ◽  
Graft Vs Host Disease ◽  
Bone Marrow Derived Cells

scholarly journals Second bone marrow transplantation for leukemic relapse without graft-vs.-host disease prophylaxis

1993 ◽  
Vol 43 (4) ◽  
pp. 324-325 ◽  
Author(s):  
Francois-Xavier Mahon ◽  
Gerald Marit ◽  
Florence Viard ◽  
Philippe Bernard ◽  
Josy Reiffers
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Marrow Transplantation ◽  
Host Disease ◽  
Graft Vs Host Disease ◽  
Leukemic Relapse

scholarly journals Development of graft-vs.-host disease-like syndrome in cyclosporine-treated rats after syngeneic bone marrow transplantation. I. Development of cytotoxic T lymphocytes with apparent polyclonal anti-Ia specificity, including autoreactivity.

1985 ◽  
Vol 161 (4) ◽  
pp. 718-730 ◽  
Author(s):  
A D Hess ◽  
L Horwitz ◽  
W E Beschorner ◽  
G W Santos
Keyword(s):  
Bone Marrow ◽  
T Lymphocytes ◽  
Class Ii ◽  
Target Cells ◽  
Histocompatibility Antigens ◽  
Host Disease ◽  
Graft Vs Host Disease ◽  
Major Histocompatibility Antigens ◽  
Multiple Strains ◽  
Inhibition Studies

Lethally irradiated rats reconstituted with syngeneic bone marrow and treated with cyclosporine (CsA) for 40 d develop a graft-vs.-host disease-like syndrome (GVHD) after CsA therapy. We attempted to assess the development of autoreactivity in these animals. Results revealed that a majority of the animals with syngeneic GVHD develop autocytotoxic T lymphocytes of the OX8 phenotype. In addition to reactivity with self, these cells were capable of lysing appropriate target cells from a variety of different rat strains. The target antigens appeared to be class II major histocompatibility antigens, because lysis could be effectively blocked by an anti-Ia monoclonal antibody. Cold target inhibition studies indicated that one effector cell was capable of lysing various target cells, and provided evidence against a polyclonal activation of multiple anti-Ia-reactive cells. These results suggested that the anti-class II autoreactive cell associated with syngeneic GVHD either recognizes a common class II determinant ("public" epitope) shared by multiple strains of rats, or was polyspecific with respect to "private" class II determinants.

scholarly journals Xenogeneic humoral Graft-Vs-Host disease following Hamster-to-Rat bone marrow transplantation

2000 ◽  
Vol 32 (5) ◽  
pp. 1036-1037 ◽  
Author(s):  
T Miki ◽  
Y.-H Lee ◽  
A Tandin ◽  
V Subbotin ◽  
R Kuddus ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Marrow Transplantation ◽  
Host Disease ◽  
Graft Vs Host Disease ◽  
Rat Bone

Graft-vs-host-disease-associated conjunctival chemosis and central serous chorioretinopathy after bone marrow transplant

2002 ◽  
Vol 134 (2) ◽  
pp. 293-295 ◽  
Author(s):  
Lulu L Cheng ◽  
Alvin K.H Kwok ◽  
Nelson M.S Wat ◽  
E.L Neoh ◽  
Hayden C.K Jon ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplant ◽  
Central Serous Chorioretinopathy ◽  
Marrow Transplant ◽  
Host Disease ◽  
Graft Vs Host Disease
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