The Cooperation between Viral ras Genes and Different Immortalizing Genes Induces the Transformation of Rat Thyroid Epithelial Cells

ras Oncogenes ◽  
1989 ◽  
pp. 311-318
Author(s):  
A. Fusco ◽  
M. T. Berlingieri ◽  
M. Grieco ◽  
M. Santoro ◽  
G. Vecchio
Keyword(s):  
Epithelial Cells ◽  
Ras Genes ◽  
Rat Thyroid

Protein kinase C activities are increased in rat thyroid epithelial cells expressing V-ras genes

1988 ◽  
Vol 157 (3) ◽  
pp. 1093-1103 ◽  
Author(s):  
A. Spina ◽  
E. Chiosi ◽  
G. Illiano ◽  
M.T. Berlingieri ◽  
A. Fusco ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Epithelial Cells ◽  
Ras Genes ◽  
Kinase C ◽  
Rat Thyroid

Increased adenylate cyclase activity in rat thyroid epithelial cells expressing viral ras genes

1987 ◽  
Vol 142 (2) ◽  
pp. 527-535 ◽  
Author(s):  
A. Spina ◽  
A. Di Donato ◽  
G. Colella ◽  
G. Illiano ◽  
M.T. Berlingieri ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Adenylate Cyclase ◽  
Cyclase Activity ◽  
Adenylate Cyclase Activity ◽  
Ras Genes ◽  
Rat Thyroid

scholarly journals Retraction for Fusco et al., “A mos Oncogene-Containing Retrovirus, Myeloproliferative Sarcoma Virus, Transforms Rat Thyroid Epithelial Cells and Irreversibly Blocks Their Differentiation Pattern”

2018 ◽  
Vol 92 (6) ◽  
pp. e02169-17
Author(s):  
Alfredo Fusco ◽  
Giuseppe Portella ◽  
Pier Paolo Di Fiore ◽  
Maria Teresa Berlingieri ◽  
Roberto Di Lauro ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Sarcoma Virus ◽  
Differentiation Pattern ◽  
Rat Thyroid

Muscarinic activation of mitogen-activated protein kinase in rat thyroid epithelial cells

2002 ◽  
Vol 14 (8) ◽  
pp. 665-672 ◽  
Author(s):  
Eugenio Jiménez ◽  
M.Idoia Gámez ◽  
M.Julia Bragado ◽  
Mercedes Montiel
Keyword(s):  
Protein Kinase ◽  
Epithelial Cells ◽  
Mitogen Activated Protein Kinase ◽  
Mitogen Activated Protein ◽  
Rat Thyroid

scholarly journals Ultrastructure of blebbing and phagocytosis of blebs by hyperplastic thyroid epithelial cells in vivo.

1977 ◽  
Vol 72 (3) ◽  
pp. 584-594 ◽  
Author(s):  
J D Zeligs ◽  
S H Wollman
Keyword(s):  
Thyroid Gland ◽  
Epithelial Cells ◽  
Cultured Cells ◽  
Ultrastructural Organization ◽  
Contractile Ring ◽  
Phagocytic Process ◽  
Different Types ◽  
Rat Thyroid

In addition to pseudopods, somewhat pleomorphic blebs were consistently found protruding from the apical surfaces of hyperplastic rat thyroid epithelial cells into the follicular lumens in vivo. Many blebs were knobby, roughly hemispherical protrusions, with a diameter of 2-3 mum. Such blebs had a densely packed microfilamentous core and contained numerous apparent ribosomes. They were morphologically similar to blebs that have been observed in a variety of cultured cells. Other blebs were larger, more elongate, and less knobby, but had a similar ultrastructural organization. Blebs of all sizes appeared to be phagocytosed on some occasions by nearby epithelial cells. The phagocytic process involved partial engulfment of the bleb by a typical epithelial pseudopod, followed by an apparent pinching-off process, presumably resulting in the separation of the bleb from its cells or origin. The pinching-off process was associated with a band of approx. 6-nm diameter microfilaments that developed within the pseudopod cytoplasm surrounding the base of the bleb and is postulated to function as a contractile ring. The finding of blebbing is an intact tissue in vivo indicates that this phenomenon is not restricted to cultured cells, and thus tends to extend the significance of in vitro observations of the process. In relation to their occurrence in the hyperplastic thyroid gland in vivo, possible interconversions are considered between different types of blebs, and between blebs and pseudopods.

scholarly journals Retraction for Fusco et al., “One- and Two-Step Transformations of Rat Thyroid Epithelial Cells by Retroviral Oncogenes”

2018 ◽  
Vol 38 (6) ◽  
Author(s):  
A. Fusco ◽  
M. T. Berlingieri ◽  
P. P. Di Fiore ◽  
G. Portella ◽  
M. Grieco ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Rat Thyroid

Mitosis in rat thyroid epithelial cells in vivo

1979 ◽  
Vol 66 (1) ◽  
pp. 53-77 ◽  
Author(s):  
Joseph D. Zeligs ◽  
Seymour H. Wollman
Keyword(s):  
Epithelial Cells ◽  
Rat Thyroid

Mitosis in rat thyroid epithelial cells in vivo

1979 ◽  
Vol 66 (2) ◽  
pp. 97-108 ◽  
Author(s):  
Joseph D. Zeligs ◽  
Seymour H. Wollman
Keyword(s):  
Epithelial Cells ◽  
Rat Thyroid

CFTR activation in human bronchial epithelial cells by novel benzoflavone and benzimidazolone compounds

2003 ◽  
Vol 285 (1) ◽  
pp. L180-L188 ◽  
Author(s):  
Emanuela Caci ◽  
Chiara Folli ◽  
Olga Zegarra-Moran ◽  
Tonghui Ma ◽  
Mark F. Springsteel ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
High Throughput Screening ◽  
Short Circuit ◽  
Short Circuit Current ◽  
Bronchial Epithelial Cells ◽  
Human Bronchial Epithelial Cells ◽  
Thyroid Cells ◽  
Bronchial Epithelial ◽  
Rat Thyroid ◽  
Better Than

Activators of the CFTR Cl- channel may be useful for therapy of cystic fibrosis. Short-circuit current ( Isc) measurements were done on human bronchial epithelial cells to characterize the best flavone and benzimidazolone CFTR activators identified by lead-based combinatorial synthesis and high-throughput screening. The 7,8-benzoflavone UCcf-029 was a potent activator of Cl- transport, with activating potency (<1 μM) being much better than other flavones, such as apigenin. The benzimidazolone UCcf-853 gave similar Isc but with lower potency (5–20 μM). In combination, the effect induced by maximal UCcf-029 and UCcf-029, UCcf-853, and apigenin increased strongly with increasing basal CFTR activity: for example, Kd for activation by UCcf-029 decreased from >5 to <0.4 μM with increasing basal Isc from ∼4 μA/cm2 to ∼12 μA/cm2. This dependence was confirmed in permeabilized Fischer rat thyroid cells stably expressing CFTR. Our results demonstrate efficacy of novel CFTR activators in bronchial epithelia and provide evidence that activating potency depends on basal CFTR activity.

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