The Long-Term Behavioral and Neurobiological Consequences of Treatment with Psychomotor Stimulant Drugs: Implications for Psychopathology

Author(s):  
Terry E. Robinson
2011 ◽  
Vol 35 (9) ◽  
pp. 334-338 ◽  
Author(s):  
Joanna Moncrieff ◽  
Sami Timimi

SummaryWe question whether adult attention-deficit hyperactivity disorder (ADHD) represents a discrete condition that is distinguishable from ordinary behaviour and other psychiatric disorders, and whether it is related to the childhood disorder, since adult and childhood ADHD are said to be characterised by a different range of symptoms. Although studies of stimulant drugs find marginal short-term effects, which can be explained by their known psychoactive properties, there is little evidence that there are any sustained long-term benefits of drug therapy. We suggest that adult ADHD represents one of the latest attempts to medicalise ordinary human difficulties, and that its popularity is partly dependent on marketing and the reinforcing effects of stimulants.


PEDIATRICS ◽  
1973 ◽  
Vol 51 (4) ◽  
pp. 660-667
Author(s):  
Daniel J. Safer ◽  
Richard P. Allen

The effect of the regular intake of stimulant medication for two or more years on growth in weight and height was evaluated for 63 hyperactive children, 29 of whom received dextroamphetamine, 20 of whom received methylphenidate, and 14 of whom received no medication because of parental objection. Major findings were: the long-term use of dextroamphetamine in hyperactive children causes a highly significant suppression of growth in weight and height; the long-term use of methylphenidate causes a less striking growth suppression only when daily doses over 20 mg are administered; tolerance develops to the weight suppressant effects of dextroamphetamine, but not to is inhibition of height growth; increasing the total degree of stimulant drug use over time generally increases the degree of growth suppression.


Author(s):  
Siddhi Manohar Bagwe ◽  
Pravin Popatrao Kale ◽  
Lokesh Kumar Bhatt ◽  
Kedar S. Prabhavalkar

AbstractPancytopenia is a health condition in which there is a reduction in the amount of leucocytes, erythrocytes and thrombocytes. If more than one of the blood cells is low then the condition is called as bicytopenia. The pancytopenic condition is observed in treatment of diseased conditions like thalassemia and hepatitis C. Iatrogenically pancytopenia is caused by some antibiotics and anti-HCV drugs. Medical conditions like aplastic anaemia, lymphoma, copper deficiency, and so forth can also cause pancytopenia. Pancytopenia can in turn decrease the immunity of the person and thereby can be fatal. Current therapies for pancytopenia include bone marrow stimulant drugs, blood transfusion and bone marrow transplant. The current therapies are very excruciating and have long-term side-effects. Therefore, treating these condition using herbal drugs is very important. Herbs like wheatgrass, papaya leaves and garlic are effective in treating single lineage cytopenias. The present review is focused on the potential effects of natural herbs for the treatment of pancytopenia.


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