copper deficiency
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2021 ◽  
Vol 4 (6) ◽  
pp. 27188-27194
Author(s):  
Louise Azevedo Lobo- Lopes ◽  
Sebastião Eurico de Melo- Souza ◽  
Vicente Mamede de Arruda Filho ◽  
Marco Aurélio Fraga Borges

Copper is an essential enzymatic cofactor in many stages of normal functioning of human body, acting mainly in hematological, vascular and neurological functions. Its deficiency is linked to some conditions as highly isolated oral zinc intake, parenteral nutrition and after bariatric surgery. Neurological symptoms due copper deficiency include gait abnormalities, sensitive ataxia and sensitive neuropathic symptoms. We present a case of copper deficiency myelopathy after bariatric surgery. Copper deficiency myelopathy is poorly diagnosed, being imperative the early recognition of the condition aiming better outcomes and neurological recovery.


2021 ◽  
Vol 38 (4) ◽  
pp. 450-461
Author(s):  
Yujin Kim ◽  
Hyun Jung Shin ◽  
Hye Jung Bae ◽  
Nigh Choi ◽  
Eun Jung Cho ◽  
...  

2021 ◽  
Vol 2021 ◽  
pp. 1-3
Author(s):  
Thomas Luo ◽  
Joanna Zurko ◽  
John Astle ◽  
Nirav N. Shah

Copper deficiency is a rare nutritional deficiency with hematological manifestations that mimic those found in myelodysplastic syndrome, a hematological malignancy incurable without allogeneic hematopoietic stem cell transplantation. Bone marrow biopsy findings and peripheral blood counts are oftentimes insufficient to differentiate the two conditions. Moreover, the symptoms of copper deficiency can arise years after the surgery, making diagnosis a challenge. In patients with new-onset pancytopenia, copper deficiency must be considered on the differential, especially in the setting of known risk factors such as bariatric surgery, zinc supplementation, and celiac disease. Herein, we present a case of a 61-year-old female with a remote history of gastric bypass being evaluated for MDS in the context of progressive pancytopenia and new-onset paresthesias. The patient was found to have low serum copper and ceruloplasmin. Copper supplementation largely resolved the hematological abnormalities, but the limb paresthesias remain. This case highlights the need to identify copper deficiency early and distinguish it from MDS in order to prevent permanent neurological deficits and catastrophic response should the patient undergo hematopoietic stem cell transplantation.


Author(s):  
FNU Amisha ◽  
Prachi Saluja ◽  
Nitesh Gautam ◽  
Shubham Biyani ◽  
Sunilkumar Kakadia

Introduction: Copper deficiency or hypocupraemia is a rare cause of anaemia and neutropenia. Case description: We hereby present the case of a 34-year-old female with gastric bypass surgery who presented with neutropenic fever, abdominal pain and diarrhoea, later found to have extended-spectrum beta-lactamase resistant Escherichia coli urinary tract infection and small bowel bacterial overgrowth syndrome, with her anaemia and neutropenia being caused by copper deficiency due to hyperzincaemia induced by using zinc denture adhesive cream. Discussion: Various causes of copper deficiency have been recognized including, but not limited to, malnutrition, gastrectomy, gastric bypass surgery, protein-losing enteropathies (coeliac disease, tropical sprue), Wilson disease and Menkes syndrome. Copper deficiency caused by zinc overuse is not very prevalent. The haematologic abnormalities associated with copper deficiency are neutropenia, sideroblastic anaemia and/or pancytopenia. Conclusion: Because of its low prevalence and nonspecific haematologic and clinical manifestations, the diagnosis of zinc-induced copper deficiency (ZICD) can be missed.


2021 ◽  
Vol 9 (29) ◽  
pp. 8825-8830
Author(s):  
Hiromitsu Ohmori ◽  
Hiroko Kodama ◽  
Masahiko Takemoto ◽  
Masami Yamasaki ◽  
Tomio Matsumoto ◽  
...  

2021 ◽  
Author(s):  
Anna Schulten ◽  
Bjoern Pietzenuk ◽  
Julia Quintana ◽  
Marcus Krause ◽  
Regina Feil ◽  
...  

Copper (Cu) is a cofactor of around 300 Arabidopsis proteins including photosynthetic and mitochondrial electron transfer chain enzymes critical for ATP production and carbon fixation. Plant acclimation to Cu deficiency requires the transcription factor SQUAMOSA PROMOTER-BINDING PROTEIN-LIKE7 (SPL7). We report that in the wild type and in the spl7-1 mutant, respiratory electron flux via Cu-dependent cytochrome c oxidase remained unaffected under both normal and low-Cu cultivation conditions. Contrary to the wild type, supplementing Cu-deficient media with exogenous sugar failed to stimulate growth of spl7-1. The spl7-1 mutant accumulated carbohydrates including the signaling sugar trehalose 6-phosphate, as well as ATP and NADH, also under normal Cu supply and without sugar supplementation. Late flowering of spl7 1 was in agreement with its attenuated sugar responsiveness. Functional TOR and SnRK1 kinase signaling in spl7-1 suggested against fundamental defects in these energy-signaling hubs. Sequencing of chromatin immunoprecipitates combined with transcriptomics identified direct targets of SPL7-mediated positive regulation, including FE SUPEROXIDE DISMUTASE1 (FSD1), COPPER-DEFICIENCY-INDUCED TRANSCRIPTION FACTOR1 (CITF1) and uncharacterized bHLH23 (CITF2), as well as an enriched upstream GTACTRC motif. In summary, transducing energy availability into growth and reproductive development requires the function of SPL7. Our results could help to increase crop yields, especially on Cu-deficient soils.


Cureus ◽  
2021 ◽  
Author(s):  
Mohammad Mousbah AL-Tabbaa ◽  
Emily Horvath
Keyword(s):  

eJHaem ◽  
2021 ◽  
Author(s):  
Kaori Uchino ◽  
Lam Vu Quang ◽  
Megumi Enomoto ◽  
Yuta Nakano ◽  
Saki Yamada ◽  
...  
Keyword(s):  

Author(s):  
Carmelo Gurnari ◽  
Heesun J. Rogers
Keyword(s):  

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