Developmental Regulation of Myelin-Associated Genes in the Normal and the Myelin Deficient Mutant Rat

1990 ◽  
pp. 11-22 ◽  
Author(s):  
M. N. Gordon ◽  
S. Kumar ◽  
A. Espinosa de los Monteros ◽  
S. Scully ◽  
M.-S. Zhang ◽  
...  
Keyword(s):  
Developmental Regulation ◽  
Deficient Mutant ◽  
Myelin Deficient ◽  
Mutant Rat

Extracellular potassium activity and axonal conduction in spinal cord of the myelin-deficient mutant rat

1989 ◽  
Vol 106 (1) ◽  
pp. 41-51 ◽  
Author(s):  
Wise Young ◽  
Jack Rosenbluth ◽  
Joan C. Wojak ◽  
Kaoru Sakatani ◽  
Hyoun Kim
Keyword(s):  
Spinal Cord ◽  
Extracellular Potassium ◽  
Deficient Mutant ◽  
Axonal Conduction ◽  
Myelin Deficient ◽  
Mutant Rat

Low myelin basic protein levels and normal myelin in peripheral nerves of myelin deficient mutant mice (MLD)

Neuroscience ◽  
1980 ◽  
Vol 5 (12) ◽  
pp. 2315-2320 ◽  
Author(s):  
J.-M. Matthieu ◽  
H. Ginalski ◽  
R.L. Friede ◽  
S.R. Cohen
Keyword(s):  
Myelin Basic Protein ◽  
Peripheral Nerves ◽  
Basic Protein ◽  
Mutant Mice ◽  
Deficient Mutant ◽  
Protein Levels ◽  
Myelin Deficient

scholarly journals Myelin instability and oligodendrocyte metabolism in myelin-deficient mutant mice.

1986 ◽  
Vol 103 (6) ◽  
pp. 2673-2682 ◽  
Author(s):  
J M Matthieu ◽  
J M Roch ◽  
F X Omlin ◽  
I Rambaldi ◽  
G Almazan ◽  
...  
Keyword(s):  
Inclusion Bodies ◽  
Basic Protein ◽  
Developmental Change ◽  
Active Phase ◽  
Mutant Mice ◽  
Molecular Forms ◽  
Deficient Mutant ◽  
Compact Structure ◽  
Myelin Associated Glycoprotein ◽  
Myelin Deficient

During the active phase of myelination in myelin-deficient mutant mice (mld), myelin basic protein (MBP) synthesis is defective and the myelin lamellae are uncompacted. In these mutants, we found a fast metabolism of the myelin-associated glycoprotein (MAG) and of sulfatides, and the presence of cholesterol esters and a degradation product of MAG, dMAG, indicating that mld myelin was unstable. The increased synthesis of MAG and Wolfgram protein, two proteins present in uncompacted myelin sheath and paranodal loops, was demonstrated by high levels of messengers. Simultaneously, we found an accumulation of inclusion bodies, vacuoles, and rough endoplasmic reticulum in mld oligodendrocytes. This material was heavily immunostained for MAG. Furthermore, the developmental change between the two molecular forms of MAG (p72MAG/p67MAG) was delayed in mld mice. In 85-d-old mld mice, the MBP content increased and myelin lamellae became better compacted. In these mutants, dMAG was absent and MAG mRNAs were found in normal amounts. Furthermore, the fine structure of mld oligodendrocytes was normal and the MAG immunostaining was similar to age-matched controls. These results support a functional role for MBP in maintaining the metabolic stability and the compact structure of myelin. Furthermore, in the absence of MBP and myelin compaction, the regulation of the synthesis of at least two membrane proteins related to myelin cannot proceed.

Ambiguus motoneurons innervating laryngeal and esophageal muscles are malpositioned in the Reelin-deficient mutant rat, Shaking Rat Kawasaki

2007 ◽  
Vol 127 (2) ◽  
pp. 213-220 ◽  
Author(s):  
Kaheita Hirasugi ◽  
Yasuo Hisa ◽  
Tomiyoshi Setsu ◽  
Toshio Terashima
Keyword(s):  
Deficient Mutant ◽  
Mutant Rat

The role of myelination in learning performance observed in two strains of myelin-deficient mutant mice (shiverer and mld)

1988 ◽  
Vol 50 (2) ◽  
pp. 184-192 ◽  
Author(s):  
Kentaro Inagawa ◽  
Shigeru Watanabe ◽  
Yasuzo Tsukada ◽  
Katsuhiko Mikoshiba
Keyword(s):  
Mutant Mice ◽  
Learning Performance ◽  
Deficient Mutant ◽  
Myelin Deficient
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