Interactions between Dietary Proteins and the Human System: Implications for Oral Tolerance and Food-Related Diseases

1997 ◽  
pp. 183-193 ◽  
Author(s):  
William E. Barbeau
Keyword(s):  
Oral Tolerance ◽  
Dietary Proteins ◽  
Human System

scholarly journals Effect of a protein-free diet in the development of food allergy and oral tolerance in BALB/c mice

2015 ◽  
Vol 113 (6) ◽  
pp. 935-943 ◽  
Author(s):  
Josiely Paula-Silva ◽  
Andrezza Fernanda Santiago ◽  
Rafael Pires Oliveira ◽  
Magda Luciana Paula Rosa ◽  
Claudia Rocha Carvalho ◽  
...  
Keyword(s):  
Food Allergy ◽  
Oral Tolerance ◽  
Secretory Iga ◽  
Control Group ◽  
Immune Reactivity ◽  
Dietary Proteins ◽  
Balanced Diet ◽  
Acid Diet ◽  
Single Oral Administration ◽  
Protein Free Diet

The aim of the present study was to investigate the effect of a protein-free diet in the induction of food allergy and oral tolerance in BALB/c mice. The experimental model used was mice that were fed, since weaning up to adulthood, a balanced diet in which all dietary proteins were replaced by amino acid diet (Aa). The absence of dietary proteins did not prevent the development of food allergy to ovalbumin (OVA) in these mice. However, Aa-fed mice produced lower levels of IgE, secretory IgA and cytokines. In addition, when compared with mice from control group, Aa-fed mice had a milder aversive reaction to the allergen measured by consumption of OVA-containing solution and weight loss during food allergy development. In addition, mice that did not have dietary proteins in their diets were less susceptible to induction of oral tolerance. One single oral administration was not enough to suppress specific serum Ig and IgG1 levels in the Aa-fed group, although it was efficient to induce suppression in the control group. The present results indicate that the stimulation by dietary proteins alters both inflammatory reactivity and regulatory immune reactivity in mice probably due to their effect in the maturation of the immune system.

Generation of immunoregulatory CD25+CD4+T cells following induction of oral tolerance

2001 ◽  
Vol 120 (5) ◽  
pp. A321-A321
Author(s):  
A KHORUTS ◽  
K THORSTENSON
Keyword(s):  
T Cells ◽  
Cd4 T Cells ◽  
Oral Tolerance

Studying Complex Human-System Behaviour: Human-in-the-loop Simulation Requirements

2007 ◽  
Author(s):  
David Crone ◽  
Penelope Sanderson ◽  
Neelam Naikar
Keyword(s):  
Human System ◽  
Human In The Loop ◽  
System Behaviour

Oral tolerance prevents the development of experimental asthma

1997 ◽  
Vol 56 (1-3) ◽  
pp. 329
Author(s):  
M Russo
Keyword(s):  
Oral Tolerance
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