Structure and Regulation of Duck Globin Genes

1984 ◽  
pp. 109-129 ◽  
Author(s):  
Gary V. Paddock ◽  
Fu-Kuen Lin ◽  
Robert Frankis ◽  
William McNeill ◽  
Jim Gaubatz
Keyword(s):  
Globin Genes

Gene expression and structure of globin genes of carp

2002 ◽  
Vol 68 (sup2) ◽  
pp. 1289-1290
Author(s):  
SONOMI MINAGAWA ◽  
MASATO MIYATA ◽  
IKUO HIRONO ◽  
TAKASHI AOKI
Keyword(s):  
Gene Expression ◽  
Globin Genes

scholarly journals Repetitive DNA sequences near three humanβ-type globin genes

1980 ◽  
Vol 8 (15) ◽  
pp. 3319-3333 ◽  
Author(s):  
Lesley W. Coggins ◽  
G.Joan Grindlay ◽  
J.Keith Vass ◽  
Alison A. Slater ◽  
Paul Montague ◽  
...  
Keyword(s):  
Repetitive Dna ◽  
Dna Sequences ◽  
Repetitive Dna Sequences ◽  
Globin Genes

scholarly journals CD14+ monocytes repress gamma globin expression at early stages of erythropoiesis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Steven Heshusius ◽  
Esther Heideveld ◽  
Marieke von Lindern ◽  
Emile van den Akker
Keyword(s):  
Mononuclear Cells ◽  
Therapeutic Option ◽  
Globin Genes ◽  
Beta Globin ◽  
Hematopoietic Progenitors ◽  
Peripheral Blood Mononuclear ◽  
Temporal Regulation ◽  
Gamma Globin ◽  
Cd34 Cells ◽  
Adult Hemoglobin

AbstractIn β-hemoglobinopathies, reactivation of gamma- at the expense of beta-globin is a prominent therapeutic option. Expression of the globin genes is not strictly intrinsically regulated during erythropoiesis, supported by the observation that fetal erythroid cells switch to adult hemoglobin expression when injected in mice. We show cultured erythroblasts are a mix of HbA restrictive and HbA/HbF expressing cells and that the proportion of cells in the latter population depends on the starting material. Cultures started from CD34+ cells contain more HbA/HbF expressing cells compared to erythroblasts cultured from total peripheral blood mononuclear cells (PBMC). Depletion of CD14+ cells from PBMC resulted in higher HbF/HbA percentages. Conversely, CD34+ co-culture with CD14+ cells reduced the HbF/HbA population through cell–cell proximity, indicating that CD14+ actively repressed HbF expression in adult erythroid cultures. RNA-sequencing showed that HbA and HbA/HbF populations contain a limited number of differentially expressed genes, aside from HBG1/2. Co-culture of CD14+ cells with sorted uncommitted hematopoietic progenitors and CD34-CD36+ erythroblasts showed that hematopoietic progenitors prior to the hemoglobinized erythroid stages are more readily influenced by CD14+ cells to downregulate expression of HBG1/2, suggesting temporal regulation of these genes. This possibly provides a novel therapeutic avenue to develop β-hemoglobinopathies treatments.

scholarly journals Hemoglobin switching in sheep. Cloning and characterization of the beta A and beta-like embryonic globin genes from genomic DNA.

1980 ◽  
Vol 255 (7) ◽  
pp. 3204-3211
Author(s):  
P.J. Kretschmer ◽  
R.E. Kaufman ◽  
H.C. Coon ◽  
M.J. Chen ◽  
C.E. Geist ◽  
...  
Keyword(s):  
Genomic Dna ◽  
Globin Genes ◽  
Hemoglobin Switching

scholarly journals Tarsius δ- and β-globin genes: conversions, evolution, and systematic implications

1989 ◽  
Vol 264 (1) ◽  
pp. 68-79
Author(s):  
B F Koop ◽  
D Siemieniak ◽  
J L Slightom ◽  
M Goodman ◽  
J Dunbar ◽  
...  
Keyword(s):  
Globin Genes

scholarly journals Expression of human gamma-globin genes in human erythroleukemia (K562) cells.

1987 ◽  
Vol 262 (35) ◽  
pp. 17051-17057
Author(s):  
M Donovan-Peluso ◽  
S Acuto ◽  
M Swanson ◽  
C Dobkin ◽  
A Bank
Keyword(s):  
K562 Cells ◽  
Globin Genes ◽  
Gamma Globin
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