Measurement of Hematopoietic Stem Cell Proliferation, Self-Renewal, and Expansion Potential

Author(s):  
Ivan N. Rich
1991 ◽  
Vol 628 (1 Negative Regu) ◽  
pp. 126-139 ◽  
Author(s):  
ARTHUR E. BOGDEN ◽  
PATRICE CARDE ◽  
EVELYNE DESCHAMPS DE PAILLETTE ◽  
JACQUES-PIERRE MOREAU ◽  
MAURICE TUBIANA ◽  
...  

1992 ◽  
Vol 47 (9) ◽  
pp. 1324-1332 ◽  
Author(s):  
Jens Freund ◽  
Afroditi Kapurniotu ◽  
Tadeusz A. Holak ◽  
Maryse Lenfant ◽  
Wolfgang Voelter

The solid phase synthesis of the inhibitor of hematopoietic stem cell proliferation, Ac–Ser–Asp–Lys–Pro–OH, and its derivative Ac–Ala–Asp–Lys–Pro–OH is described. 1H and 13C NMR investigations demonstrate that both peptides show no prefered conformation in water solution. Both peptides exist in a Pro-cis-trans equilibrium ratio of 9 (trans) : 1 (cis). Thymosin β4 is believed to be the precursor molecule of the tetrapeptide Ac–SDKP. The attachement of the random coil tetrapeptide to a rigid helical fragment could facilitate its in vivo enzymatic cleavage.


Science ◽  
2010 ◽  
Vol 328 (5986) ◽  
pp. 1689-1693 ◽  
Author(s):  
L. Yvan-Charvet ◽  
T. Pagler ◽  
E. L. Gautier ◽  
S. Avagyan ◽  
R. L. Siry ◽  
...  

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