Amelioration of Chemotherapy-Induced Toxicity by Cotreatment with AcSDKP, a Tetrapeptide Inhibitor of Hematopoietic Stem Cell Proliferation

1991 ◽  
Vol 628 (1 Negative Regu) ◽  
pp. 126-139 ◽  
Author(s):  
ARTHUR E. BOGDEN ◽  
PATRICE CARDE ◽  
EVELYNE DESCHAMPS DE PAILLETTE ◽  
JACQUES-PIERRE MOREAU ◽  
MAURICE TUBIANA ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Hematopoietic Stem ◽  
Stem Cell Proliferation

scholarly journals Synthesis and Two-Dimensional 1Η and 13C NMR Investigations of an Inhibitor of Hematopoietic Stem Cell Proliferation Ac–Ser–Asp–Lys–Pro–OH

1992 ◽  
Vol 47 (9) ◽  
pp. 1324-1332 ◽  
Author(s):  
Jens Freund ◽  
Afroditi Kapurniotu ◽  
Tadeusz A. Holak ◽  
Maryse Lenfant ◽  
Wolfgang Voelter
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Solid Phase ◽  
Water Solution ◽  
Random Coil ◽  
Hematopoietic Stem ◽  
Stem Cell Proliferation ◽  
Equilibrium Ratio

The solid phase synthesis of the inhibitor of hematopoietic stem cell proliferation, Ac–Ser–Asp–Lys–Pro–OH, and its derivative Ac–Ala–Asp–Lys–Pro–OH is described. 1H and 13C NMR investigations demonstrate that both peptides show no prefered conformation in water solution. Both peptides exist in a Pro-cis-trans equilibrium ratio of 9 (trans) : 1 (cis). Thymosin β4 is believed to be the precursor molecule of the tetrapeptide Ac–SDKP. The attachement of the random coil tetrapeptide to a rigid helical fragment could facilitate its in vivo enzymatic cleavage.

scholarly journals ATP-Binding Cassette Transporters and HDL Suppress Hematopoietic Stem Cell Proliferation

Science ◽  
2010 ◽  
Vol 328 (5986) ◽  
pp. 1689-1693 ◽  
Author(s):  
L. Yvan-Charvet ◽  
T. Pagler ◽  
E. L. Gautier ◽  
S. Avagyan ◽  
R. L. Siry ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Atp Binding ◽  
Hematopoietic Stem ◽  
Stem Cell Proliferation ◽  
Atp Binding Cassette Transporters ◽  
Atp Binding Cassette

Angiotensin II regulates hematopoietic stem cell proliferation, differentiation and engraftment efficacy

2014 ◽  
Vol 42 (8) ◽  
pp. S43
Author(s):  
Seungbum Kim ◽  
Christopher Cogle ◽  
Michael Zingler ◽  
Edward Scott ◽  
Mohan Raizada
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Angiotensin Ii ◽  
Hematopoietic Stem Cell ◽  
Hematopoietic Stem ◽  
Stem Cell Proliferation

scholarly journals Leukemic marrow infiltration reveals a novel role for Egr3 as a potent inhibitor of normal hematopoietic stem cell proliferation

Blood ◽  
2015 ◽  
Vol 126 (11) ◽  
pp. 1302-1313 ◽  
Author(s):  
Hui Cheng ◽  
Sha Hao ◽  
Yanfeng Liu ◽  
Yakun Pang ◽  
Shihui Ma ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Cell Proliferation ◽  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Potent Inhibitor ◽  
Hematopoietic Stem ◽  
Stem Cell Proliferation ◽  
Leukemic Infiltration ◽  
Key Points

Key Points Increased quiescence of HSCs and HPCs in leukemogenesis, and reversible suppression of HSCs was observed in leukemic bone marrow. A novel inhibitory role of Egr3 in HSC proliferation was revealed by leukemic infiltration in bone marrow.

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