Non-epithelial Renal Neoplasms of the Adult Kidney

The Kidney ◽  
2016 ◽  
pp. 141-148
Author(s):  
Chad R. Ritch ◽  
Giovanna A. Giannico ◽  
Lan L. Gellert ◽  
Peter E. Clark ◽  
Omar Hameed
Keyword(s):  
Renal Neoplasms ◽  
Adult Kidney

Polycystin expression is temporally and spatially regulated during renal development

1997 ◽  
Vol 272 (5) ◽  
pp. F602-F609 ◽  
Author(s):  
J. Van Adelsberg ◽  
S. Chamberlain ◽  
V. D'Agati
Keyword(s):  
Plasma Membranes ◽  
Predicted Amino Acid Sequence ◽  
Renal Development ◽  
Polycystic Kidney ◽  
Fetal Kidney ◽  
Spatial Regulation ◽  
Adult Kidney ◽  
A Cell ◽  
Autosomal Dominant Polycystic Kidney ◽  
Membrane Spanning

Mutations in PKD1 cause autosomal dominant polycystic kidney disease (ADPKD), a common genetic disease in which cysts form from kidney tubules. The predicted product of this gene is a novel protein with cell-adhesive and membrane-spanning domains. To test the hypothesis that polycystin, the product of the PKD1 gene, is a cell adhesion molecule, we raised antibodies against peptides derived from the unduplicated, membrane-spanning portion of the predicted amino acid sequence. These antibodies recognized membrane-associated polypeptides of 485 and 245 kDa in human fetal kidney homogenates. Expression was greater in fetal than adult kidney by both Western blot analysis and immunofluorescence. In fetal kidney, polycystin was localized to the plasma membranes of ureteric bud and comma and S-shaped bodies. However, in more mature tubules in fetal kidney, in adult kidney, and in polycystic kidney, the majority of polycystin staining was intracellular. The temporal and spatial regulation of polycystin expression during renal development lead us to speculate that polycystin may play a role in nephrogenesis.

Management and Extended Outcome of Patients With Synchronous Bilateral Solid Renal Neoplasms in the Absence of von Hippel-Lindau Disease

2000 ◽  
Vol 75 (10) ◽  
pp. 1020-1026 ◽  
Author(s):  
Michael L. Blute ◽  
Christopher L. Amling ◽  
Sandra C. Bryant ◽  
Horst Zincke
Keyword(s):  
Renal Neoplasms ◽  
Von Hippel Lindau ◽  
Von Hippel Lindau Disease

scholarly journals Introduction of the Grayscale Median for Ultrasound Tissue Characterization of the Transplanted Kidney

Diagnostics ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 390
Author(s):  
Camilo G. Sotomayor ◽  
Stan Benjamens ◽  
Hildebrand Dijkstra ◽  
Derya Yakar ◽  
Cyril Moers ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Tissue Characterization ◽  
Kidney Transplant Recipients ◽  
Systematic Assessment ◽  
Ultrasound Tissue Characterization ◽  
Adult Kidney ◽  
Mersenne Twister ◽  
History Of

Ultrasound examination is advised for early post-kidney transplant assessment. Grayscale median (GSM) quantification is novel in the kidney transplant field, with no systematic assessment previously reported. In this prospective cohort study, we measured the post-operative GSM in a large cohort of adult kidney transplant recipients (KTR) who consecutively underwent Doppler ultrasound directly after transplantation (within 24 h), compared it with GSM in nontransplanted patients, and investigated its association with baseline and follow-up characteristics. B-mode images were used to calculate the GSM in KTR and compared with GSM data in nontransplanted patients, as simulated from summary statistics of the literature using a Mersenne twister algorithm. The association of GSM with baseline and 1-year follow-up characteristics were studied by means of linear regression analyses. In 282 KTR (54 ± 15 years old, 60% male), the median (IQR) GSM was 55 (45–69), ranging from 22 to 124 (coefficient of variation = 7.4%), without differences by type of donation (p = 0.28). GSM in KTR was significantly higher than in nontransplanted patients (p < 0.001), and associated with systolic blood pressure, history of cardiovascular disease, and donor age (std. β = 0.12, −0.20, and 0.13, respectively; p < 0.05 for all). Higher early post-kidney transplant GSM was not associated with 1-year post-kidney transplant function parameters (e.g., measured and estimated glomerular filtration rate). The data provided in this study could be used as first step for further research on the application of early postoperative ultrasound in KTR.

INITIATING GENETIC EVENTS IN SMALL RENAL NEOPLASMS DETECTED BY COMPARATIVE GENOMIC HYBRIDIZATION

1998 ◽  
Vol 160 (4) ◽  
pp. 1557-1561 ◽  
Author(s):  
JOSEPH C. PRESTI ◽  
HOLGER MOCH ◽  
ARNOLD B. GELB ◽  
DANH HUYNH ◽  
FREDERIC M. WALDMAN
Keyword(s):  
Comparative Genomic Hybridization ◽  
Comparative Genomic ◽  
Renal Neoplasms ◽  
Genomic Hybridization ◽  
Genetic Events

scholarly journals A developmentally plastic adult mouse kidney cell line spontaneously generates multiple adult kidney structures

2015 ◽  
Vol 463 (4) ◽  
pp. 1334-1340 ◽  
Author(s):  
Carol F. Webb ◽  
Michelle L. Ratliff ◽  
Rebecca Powell ◽  
Celeste R. Wirsig-Wiechmann ◽  
Olga Lakiza ◽  
...  
Keyword(s):  
Cell Line ◽  
Kidney Cell ◽  
Adult Mouse ◽  
Mouse Kidney ◽  
Kidney Cell Line ◽  
Adult Kidney

Extracorporeal photopheresis for the treatment of graft rejection in 33 adult kidney transplant recipients

2019 ◽  
Vol 58 (4) ◽  
pp. 515-524
Author(s):  
Mathilde Tamain ◽  
Johnny Sayegh ◽  
Arnaud Lionet ◽  
Philippe Grimbert ◽  
Carole Philipponnet ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Graft Rejection ◽  
Extracorporeal Photopheresis ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Adult Kidney

scholarly journals Beyond a Passive Conduit: Implications of Lymphatic Biology for Kidney Diseases

2020 ◽  
Vol 31 (6) ◽  
pp. 1178-1190 ◽  
Author(s):  
Daniyal J. Jafree ◽  
David A. Long
Keyword(s):  
Kidney Disease ◽  
Therapeutic Potential ◽  
Kidney Diseases ◽  
Transplant Rejection ◽  
Lymphatic Vessels ◽  
Renal Physiology ◽  
Clear Fluid ◽  
Adult Kidney ◽  
And Function ◽  
Development Structure

The kidney contains a network of lymphatic vessels that clear fluid, small molecules, and cells from the renal interstitium. Through modulating immune responses and via crosstalk with surrounding renal cells, lymphatic vessels have been implicated in the progression and maintenance of kidney disease. In this Review, we provide an overview of the development, structure, and function of lymphatic vessels in the healthy adult kidney. We then highlight the contributions of lymphatic vessels to multiple forms of renal pathology, emphasizing CKD, transplant rejection, and polycystic kidney disease and discuss strategies to target renal lymphatics using genetic and pharmacologic approaches. Overall, we argue the case for lymphatics playing a fundamental role in renal physiology and pathology and treatments modulating these vessels having therapeutic potential across the spectrum of kidney disease.

scholarly journals Complications of Radiofrequency Ablation of Hepatic, Pulmonary, and Renal Neoplasms

2010 ◽  
Vol 27 (03) ◽  
pp. 285-295 ◽  
Author(s):  
Matthew Howenstein ◽  
Kent Sato
Keyword(s):  
Radiofrequency Ablation ◽  
Renal Neoplasms
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