Repetitive Behavioral Assessments for Compound Screening in Mouse Models of Autism Spectrum Disorders

2016 ◽  
pp. 293-310 ◽  
Author(s):  
Stacey J. Sukoff Rizzo
Keyword(s):  
Autism Spectrum Disorders ◽  
Mouse Models ◽  
Autism Spectrum ◽  
Compound Screening ◽  
Behavioral Assessments ◽  
Spectrum Disorders

scholarly journals Prosocial effects of oxytocin in two mouse models of autism spectrum disorders

2013 ◽  
Vol 72 ◽  
pp. 187-196 ◽  
Author(s):  
Brian L. Teng ◽  
Randal J. Nonneman ◽  
Kara L. Agster ◽  
Viktoriya D. Nikolova ◽  
Tamara T. Davis ◽  
...  
Keyword(s):  
Autism Spectrum Disorders ◽  
Mouse Models ◽  
Autism Spectrum ◽  
Spectrum Disorders

scholarly journals Synaptic Plasticity in Mouse Models of Autism Spectrum Disorders

2012 ◽  
Vol 16 (6) ◽  
pp. 369 ◽  
Author(s):  
Leeyup Chung ◽  
Alexandra L. Bey ◽  
Yong-Hui Jiang
Keyword(s):  
Autism Spectrum Disorders ◽  
Synaptic Plasticity ◽  
Mouse Models ◽  
Autism Spectrum ◽  
Spectrum Disorders

scholarly journals mTOR Suppresses Macroautophagy During Striatal Postnatal Development and Is Hyperactive in Mouse Models of Autism Spectrum Disorders

2020 ◽  
Vol 14 ◽  
Author(s):  
Ori J. Lieberman ◽  
Veronica Cartocci ◽  
Irena Pigulevskiy ◽  
Maya Molinari ◽  
Josep Carbonell ◽  
...  
Keyword(s):  
Autism Spectrum Disorders ◽  
Postnatal Development ◽  
Mouse Models ◽  
Autism Spectrum ◽  
Spectrum Disorders

scholarly journals Understanding intellectual disability and autism spectrum disorders from common mouse models: synapses to behaviour

Open Biology ◽  
2019 ◽  
Vol 9 (6) ◽  
pp. 180265 ◽  
Author(s):  
Vijaya Verma ◽  
Abhik Paul ◽  
Anjali Amrapali Vishwanath ◽  
Bhupesh Vaidya ◽  
James P. Clement
Keyword(s):  
Autism Spectrum Disorders ◽  
Intellectual Disability ◽  
Mouse Models ◽  
Autism Spectrum ◽  
Therapeutic Strategies ◽  
World Population ◽  
Normal Brain ◽  
Social And Emotional ◽  
Spectrum Disorders ◽  
Emotional Deficits

Normal brain development is highly dependent on the timely coordinated actions of genetic and environmental processes, and an aberration can lead to neurodevelopmental disorders (NDDs). Intellectual disability (ID) and autism spectrum disorders (ASDs) are a group of co-occurring NDDs that affect between 3% and 5% of the world population, thus presenting a great challenge to society. This problem calls for the need to understand the pathobiology of these disorders and to design new therapeutic strategies. One approach towards this has been the development of multiple analogous mouse models. This review discusses studies conducted in the mouse models of five major monogenic causes of ID and ASDs: Fmr1, Syngap1, Mecp2, Shank2/3 and Neuroligins/Neurnexins. These studies reveal that, despite having a diverse molecular origin, the effects of these mutations converge onto similar or related aetiological pathways, consequently giving rise to the typical phenotype of cognitive, social and emotional deficits that are characteristic of ID and ASDs. This convergence, therefore, highlights common pathological nodes that can be targeted for therapy. Other than conventional therapeutic strategies such as non-pharmacological corrective methods and symptomatic alleviation, multiple studies in mouse models have successfully proved the possibility of pharmacological and genetic therapy enabling functional recovery.

scholarly journals Mutant Mouse Models of Autism Spectrum Disorders

2012 ◽  
Vol 33 (5) ◽  
pp. 225-239 ◽  
Author(s):  
Giovanni Provenzano ◽  
Giulia Zunino ◽  
Sacha Genovesi ◽  
Paola Sgadó ◽  
Yuri Bozzi
Keyword(s):  
Autism Spectrum Disorders ◽  
Mouse Models ◽  
Autism Spectrum ◽  
Repetitive Behaviors ◽  
Mouse Strains ◽  
Targeted Deletion ◽  
Behavioral Traits ◽  
Genetic Complexity ◽  
Spectrum Disorders ◽  
Targeted Inactivation

Autism spectrum disorders (ASDs) are a heterogeneous group of neurodevelopmental diseases characterized by a triad of specific behavioral traits: abnormal social interactions, communication deficits and stereotyped or repetitive behaviors. Several recent studies showed that ASDs have a strong genetic basis, contributing to the discovery of a number of ASD-associated genes. Due to the genetic complexity of these disorders, mouse strains with targeted deletion of ASD genes have become an essential tool to investigate the molecular and neurodevelopmental mechanisms underlying ASD. Here we will review the most relevant genetic mouse models developed by targeted inactivation of ASD-associated genes, and discuss their importance for the development of novel pharmacological therapies of these disorders.

Mouse models have limitations for development of medications for autism spectrum disorders, but also show much promise

2012 ◽  
Vol 7 (1) ◽  
pp. 1-4
Author(s):  
Stephen I Deutsch ◽  
Maria R Urbano ◽  
Christian Zemlin
Keyword(s):  
Autism Spectrum Disorders ◽  
Mouse Models ◽  
Autism Spectrum ◽  
Spectrum Disorders
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