Critical Role of GRK2 in the Prevention of Chronic Pain

2016 ◽  
pp. 187-213
Author(s):  
Faiza Baameur ◽  
Pooja Singhmar ◽  
Cobi J. Heijnen ◽  
Annemieke Kavelaars
Keyword(s):  
Chronic Pain ◽  
Critical Role ◽  
Prevention Of Chronic Pain

scholarly journals Chronic Pain and Chronic Stress: Two Sides of the Same Coin?

2017 ◽  
Vol 1 ◽  
pp. 247054701770476 ◽  
Author(s):  
Chadi G Abdallah ◽  
Paul Geha
Keyword(s):  
Decision Making ◽  
Posttraumatic Stress Disorder ◽  
Chronic Pain ◽  
Posttraumatic Stress ◽  
Chronic Stress ◽  
Stress Disorder ◽  
Internal State ◽  
Critical Role ◽  
Well Being

Pain and stress share significant conceptual and physiological overlaps. Both phenomena challenge the body’s homeostasis and necessitate decision-making to help animals adapt to their environment. In addition, chronic stress and chronic pain share a common behavioral model of failure to extinguish negative memories. Yet, they also have discrepancies such that the final brain endophenotype of posttraumatic stress disorder, depression, and chronic pain appears to be different among the three conditions, and the role of the hypothalamic-pituitary-adrenal axis remains unclear in the physiology of pain. Persistence of either stress or pain is maladaptive and could lead to compromised well-being. In this brief review, we highlight the commonalities and differences between chronic stress and chronic pain, while focusing particularly on the central role of the limbic brain. We assess the current attempts in the field to conceptualize and understand chronic pain, within the context of knowledge gained from the stress literature. The limbic brain—including hippocampus, amygdala, and ventromedial prefrontal cortex—plays a critical role in learning. These brain areas integrate incoming nociceptive or stress signals with internal state, and generate learning signals necessary for decision-making. Therefore, the physiological and structural remodeling of this learning circuitry is observed in conditions such as chronic pain, depression, and posttraumatic stress disorder, and is also linked to the risk of onset of these conditions.

The Pragmatism of Habit in Preoperative Optimization

2019 ◽  
pp. 77-104
Author(s):  
Heath B. McAnally ◽  
Beth Darnall
Keyword(s):  
Chronic Pain ◽  
Health Behaviors ◽  
Stress Management ◽  
Habit Formation ◽  
Critical Role ◽  
Healthy Diet ◽  
Behavioral Modification ◽  
Preoperative Optimization

As stated in the previous chapter’s introduction, effective preoperative optimization of patients suffering with chronic pain depends on behavioral modification. Chronic pain is largely influenced if not mediated by omission of healthy biopsychosocial-spiritual behaviors (e.g., healthy diet, sleep, exercise, and stress management patterns) and commission of unhealthy ones (e.g., pro-inflammatory diet, toxin consumption). This chapter explores the critical role of habit in directing behavior in general and, in particular, health behaviors. It examines what is currently known about the psychology and neurobiology of habit formation and maintenance. It then turns to a brief overview of the application of these concepts to the perioperative optimization of patients with chronic pain.

Brain mechanisms of chronic pain: critical role of translational approach

2021 ◽  
Author(s):  
Joana Barroso ◽  
Paulo Branco ◽  
A. Vania Apkarian
Keyword(s):  
Chronic Pain ◽  
Critical Role ◽  
Translational Approach

scholarly journals Critical role of nociceptor plasticity in chronic pain

2009 ◽  
Vol 32 (12) ◽  
pp. 611-618 ◽  
Author(s):  
David B. Reichling ◽  
Jon D. Levine
Keyword(s):  
Chronic Pain ◽  
Critical Role

The Role of the SLP in Autism Spectrum Disorder Screening and Assessment

2008 ◽  
Vol 15 (2) ◽  
pp. 50-59 ◽  
Author(s):  
Amy Philofsky
Keyword(s):  
Language Development ◽  
Critical Role ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Children With Asd ◽  
Prevalence Estimates ◽  
Notable Increase ◽  
Screening Assessment ◽  
Critical Components

AbstractRecent prevalence estimates for autism have been alarming as a function of the notable increase. Speech-language pathologists play a critical role in screening, assessment and intervention for children with autism. This article reviews signs that may be indicative of autism at different stages of language development, and discusses the importance of several psychometric properties—sensitivity and specificity—in utilizing screening measures for children with autism. Critical components of assessment for children with autism are reviewed. This article concludes with examples of intervention targets for children with ASD at various levels of language development.

A critical role of iNOS-derived Nitric Oxide (NO) and progesterone in implantation

1998 ◽  
Vol 5 (1) ◽  
pp. 115A-115A
Author(s):  
K CHWALISZ ◽  
E WINTERHAGER ◽  
T THIENEL ◽  
R GARFIELD
Keyword(s):  
Nitric Oxide ◽  
Critical Role
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