A critical role of iNOS-derived Nitric Oxide (NO) and progesterone in implantation

1998 ◽  
Vol 5 (1) ◽  
pp. 115A-115A
Author(s):  
K CHWALISZ ◽  
E WINTERHAGER ◽  
T THIENEL ◽  
R GARFIELD
Keyword(s):  
Nitric Oxide ◽  
Critical Role

Persistent Pulmonary Hypertension of the Newborn: Role of Nitric Oxide

1995 ◽  
Vol 10 (6) ◽  
pp. 270-282
Author(s):  
Stella Kourembanas
Keyword(s):  
Nitric Oxide ◽  
Pulmonary Hypertension ◽  
Structural Changes ◽  
Critical Role ◽  
Persistent Pulmonary Hypertension ◽  
Cell Contractility ◽  
Vasoactive Mediators ◽  
Nitric Oxide Therapy

Persistent pulmonary hypertension of the newborn (PPHN) is a common cause of respiratory failure in the full-term neonate. Molecular and cellular studies in vascular biology have revealed that endothelial-derived mediators play a critical role in the pathogenesis and treatment of PPHN. Endothelial-derived vasoconstrictors, like endothelin, may increase smooth muscle cell contractility and growth, leading to the physiologic and structural changes observed in the pulmonary arterioles of infants with this disease. On the other hand, decreased production of the endothelial-derived relaxing factor, nitric oxide, may exacerbate pulmonary vasoreactivity and lead to more severe pulmonary hypertension. Exogenous (inhaled) nitric oxide therapy reduces pulmonary vascular resistance and improves oxygenation. The safety and efficacy of this therapy in reducing the need for extracorporeal membrane oxygenation and decreasing long-term morbidity is being tested in several trials nationally and abroad. Understanding the basic mechanisms that regulate the gene expression and production of these vasoactive mediators will lead to improved preventive and therapeutic strategies for PPHN.

scholarly journals Critical Role of Nitric Oxide During the Apoptosis of Peripheral Blood Leukocytes from Patients with AIDS

1999 ◽  
Vol 5 (12) ◽  
pp. 812-819 ◽  
Author(s):  
M. Djavad Mossalayi ◽  
Pierre-André Becherel ◽  
Patrice Debré
Keyword(s):  
Nitric Oxide ◽  
Peripheral Blood ◽  
Critical Role ◽  
Peripheral Blood Leukocytes ◽  
Blood Leukocytes

scholarly journals Critical role of Nitric Oxide on Nicotine-Induced Hyperactivation of Dopaminergic Nigrostriatal System: Electrophysiological and Neurochemical evidence in Rats

2010 ◽  
Vol 16 (3) ◽  
pp. 127-136 ◽  
Author(s):  
Vincenzo Di Matteo ◽  
Massimo Pierucci ◽  
Arcangelo Benigno ◽  
Ennio Esposito ◽  
Giuseppe Crescimanno ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Critical Role ◽  
Nigrostriatal System

Critical Role of Val567 in Substrate Recognition by Neuronal Nitric Oxide Synthase for NO Formation Activity

2003 ◽  
Vol 32 (11) ◽  
pp. 998-999 ◽  
Author(s):  
Hiroto Takahashi ◽  
Yuko Sato ◽  
Magoli Moreau ◽  
Marie-Agnes Sari ◽  
Jean-Luc Boucher ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Substrate Recognition ◽  
Critical Role ◽  
Neuronal Nitric Oxide Synthase ◽  
No Formation ◽  
Oxide Synthase

scholarly journals The Critical Role of Tetrahydrobiopterin (BH4) Metabolism in Modulating Radiosensitivity: BH4/NOS Axis as an Angel or a Devil

2021 ◽  
Vol 11 ◽  
Author(s):  
Yang Feng ◽  
Yahui Feng ◽  
Liming Gu ◽  
Pengfei Liu ◽  
Jianping Cao ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Free Radicals ◽  
Ionizing Radiation ◽  
Molecular Mechanisms ◽  
De Novo ◽  
Antiangiogenic Therapy ◽  
Critical Role ◽  
Cellular Radiosensitivity ◽  
Normal Tissues

Ionizing radiation and radioactive materials have been widely used in industry, medicine, science and military. The efficacy of radiotherapy and adverse effects of normal tissues are closed related to cellular radiosensitivity. Molecular mechanisms underlying radiosensitivity are of significance to tumor cell radiosensitization as well as normal tissue radioprotection. 5,6,7,8-Tetrahydrobiopterin (BH4) is an essential cofactor for nitric oxide synthases (NOS) and aromatic amino acid hydroxylases, and its biosynthesis involves de novo biosynthesis and a pterin salvage pathway. In this review we overview the role of BH4 metabolism in modulating radiosensitivity. BH4 homeostasis determines the role of NOS, affecting the production of nitric oxide (NO) and oxygen free radicals. Under conditions of oxidative stress, such as UV-radiation and ionizing radiation, BH4 availability is diminished due to its oxidation, which subsequently leads to NOS uncoupling and generation of highly oxidative free radicals. On the other hand, BH4/NOS axis facilitates vascular normalization, a process by which antiangiogenic therapy corrects structural and functional flaws of tumor blood vessels, which enhances radiotherapy efficacy. Therefore, BH4/NOS axis may serve as an angel or a devil in regulating cellular radiosensitivity. Finally, we will address future perspectives, not only from the standpoint of perceived advances in treatment, but also from the potential mechanisms. These advances have demonstrated that it is possible to modulate cellular radiosensitivity through BH4 metabolism.

scholarly journals A Critical Role of the Nitric Oxide/cGMP Pathway in Corticostriatal Long-Term Depression

1999 ◽  
Vol 19 (7) ◽  
pp. 2489-2499 ◽  
Author(s):  
Paolo Calabresi ◽  
Paolo Gubellini ◽  
Diego Centonze ◽  
Giuseppe Sancesario ◽  
Maria Morello ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Critical Role ◽  
Long Term Depression ◽  
Cgmp Pathway

scholarly journals Role of protein kinase G in nitric oxide- and cGMP-induced relaxation of newborn ovine pulmonary veins

1999 ◽  
Vol 87 (3) ◽  
pp. 993-998 ◽  
Author(s):  
Yuansheng Gao ◽  
Srinivas Dhanakoti ◽  
Jean-Francois Tolsa ◽  
J. Usha Raj
Keyword(s):  
Nitric Oxide ◽  
Protein Kinase ◽  
Biochemical Study ◽  
Critical Role ◽  
Pulmonary Veins ◽  
Protein Kinase G ◽  
Fourth Generation ◽  
Cgmp Analog ◽  
A Cell

In a variety of systemic blood vessels, protein kinase G (PKG) plays a critical role in mediating relaxation induced by agents that elevate cGMP, such as nitric oxide. The role of PKG in nitric oxide- and cGMP-induced relaxation is less certain in the pulmonary circulation. In the present study, we examined the effects of inhibitors of PKG on the responses of isolated fourth-generation pulmonary veins of newborn lambs (10 ± 1 days of age) to nitric oxide and cGMP. In vessels preconstricted with endothelin-1, nitric oxide and 8-bromo-cGMP (a cell-membrane-permeable cGMP analog) induced concentration-dependent relaxation. The relaxation was significantly attenuated by β-phenyl-1, N 2-etheno-8-bromoguanosine-3′,5′-cyclic monophosphorothionate (Rp-8-Br-PET-cGMPS; a PKG inhibitor) and N-[2-(methylamino)ethyl]5-isoquinolinesulfonamide [H-8; an inhibitor of PKG and protein kinase A (PKA)] but was not affected by KT-5720 (a PKA inhibitor). Biochemical study showed that PKG activity in newborn ovine pulmonary veins was inhibited by 8-Br-PET-cGMPS and H-8 but not by KT-5720. PKA activity was not affected by 8-Br-PET-cGMPS but was inhibited by H-8 and KT-5720. These results suggest that PKG is involved in relaxation of pulmonary veins of newborn lambs induced by nitric oxide and cGMP.

scholarly journals Critical role of vascular peroxidase 1 in regulating endothelial nitric oxide synthase

Redox Biology ◽  
2017 ◽  
Vol 12 ◽  
pp. 226-232 ◽  
Author(s):  
Zhaoya Liu ◽  
Yanbo Liu ◽  
Qian Xu ◽  
Haiyang Peng ◽  
Yixin Tang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Critical Role ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide
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