Site-Specific Protein Labeling Utilizing Lipoic Acid Ligase (LplA) and Bioorthogonal Inverse Electron Demand Diels-Alder Reaction

2018 ◽  
pp. 365-387 ◽  
Author(s):  
Mathis Baalmann ◽  
Marcel Best ◽  
Richard Wombacher
Keyword(s):  
Lipoic Acid ◽  
Specific Protein ◽  
Alder Reaction ◽  
Diels Alder ◽  
Protein Labeling ◽  
Site Specific ◽  
Inverse Electron Demand ◽  
Diels Alder Reaction ◽  
Electron Demand

Two-Step Protein Labeling by Using Lipoic Acid Ligase with Norbornene Substrates and Subsequent Inverse-Electron Demand Diels-Alder Reaction

ChemBioChem ◽  
2015 ◽  
Vol 16 (8) ◽  
pp. 1158-1162 ◽  
Author(s):  
Marcel Best ◽  
Anna Degen ◽  
Mathis Baalmann ◽  
Tobias T. Schmidt ◽  
Richard Wombacher
Keyword(s):  
Lipoic Acid ◽  
Alder Reaction ◽  
Diels Alder ◽  
Protein Labeling ◽  
Inverse Electron Demand ◽  
Diels Alder Reaction ◽  
Electron Demand

A bioorthogonally activatable photosensitiser for site-specific photodynamic therapy

2020 ◽  
Vol 56 (7) ◽  
pp. 1078-1081 ◽  
Author(s):  
Yimin Zhou ◽  
Roy C. H. Wong ◽  
Gaole Dai ◽  
Dennis K. P. Ng
Keyword(s):  
Photodynamic Therapy ◽  
Alder Reaction ◽  
Diels Alder ◽  
Site Specific ◽  
Inverse Electron Demand ◽  
Diels Alder Reaction ◽  
Boron Dipyrromethene ◽  
Electron Demand

Inverse-electron-demand Diels–Alder reaction of a 1,2,4,5-tetrazine-substituted boron dipyrromethene with a biotin-conjugated trans-cyclooctene results in site-specific activation of the photoactivity of the former photosensitiser.

Site-specific one-pot triple click labeling for DNA and RNA

2018 ◽  
Vol 54 (83) ◽  
pp. 11781-11784 ◽  
Author(s):  
Marie-Luise Winz ◽  
Eva Christina Linder ◽  
Juliane Becker ◽  
Andres Jäschke
Keyword(s):  
Alder Reaction ◽  
Diels Alder ◽  
One Pot ◽  
Site Specific ◽  
Click Reactions ◽  
Inverse Electron Demand ◽  
Dna And Rna ◽  
Diels Alder Reaction ◽  
Electron Demand

We report site-specific triple click labeling for DNA and RNA in a one-pot setup by performing inverse electron demand Diels–Alder reaction and strain-promoted and copper catalyzed click reactions sequentially.

Single wall carbon nanotube (SWCNT)–gold nanorod (AuNR) conjugates via thermally-mild reaction conditions

2017 ◽  
Vol 41 (21) ◽  
pp. 12392-12396 ◽  
Author(s):  
Siting Ni ◽  
Jun Zhu ◽  
Mohamed Amine Mezour ◽  
R. Bruce Lennox
Keyword(s):  
Carbon Nanotube ◽  
Covalent Binding ◽  
Alder Reaction ◽  
Diels Alder ◽  
Gold Nanorod ◽  
Reaction Conditions ◽  
Single Wall Carbon ◽  
Inverse Electron Demand ◽  
Diels Alder Reaction ◽  
Electron Demand

A thermally-mild method for covalent binding of SWCNTs to AuNRs, based on an inverse-electron-demand Diels–Alder reaction, is established and discussed.

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