Illicit and Counterfeit Drug Analysis by Morphologically Directed Raman Spectroscopy

After more than 40 years of development, surface-enhanced Raman spectroscopy (SERS) has become a powerful and mature analytical tool. It has been widely used in surface science, materials science, biomedicine, drug analysis, food safety, environmental testing, etc. SERS technology has molecular-level detection accuracy, which can effectively amplify signals and has obvious advantages in realizing trace substance detection. In present article, a comprehensive review of the SERS technology and related applications in microbial identification is carried out, and its future research hotspots and development directions are discussed.

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Trace drug analysis by surface-enhanced Raman spectroscopy

10.1117/12.411716 ◽

2000 ◽

Cited By ~ 6

Author(s):

Stuart Farquharson ◽

Vincent Y. Lee

Keyword(s):

Raman Spectroscopy ◽

Surface Enhanced Raman Spectroscopy ◽

Drug Analysis ◽

Surface Enhanced ◽

Surface Enhanced Raman

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Counterfeit formulations: analytical perspective on anorectics

Forensic Toxicology ◽

10.1007/s11419-020-00564-5 ◽

2021 ◽

Author(s):

Dan Osei Mensah Bonsu ◽

Constance Afoakwah ◽

Maria de la Paz Aguilar-Caballos

Keyword(s):

Method Development ◽

Legal Status ◽

Chemical Constituents ◽

Analytical Techniques ◽

Drug Analysis ◽

Counterfeit Drugs ◽

Preparation Methods ◽

Specific Chemical ◽

Counterfeit Drug ◽

International Agencies

Abstract Purpose This paper examines the scope of anorectics in counterfeit weight-reducing formulations and provides insight into the present state of research in determining such adulterants. Analytical techniques utilised in profiling adulterants found in slimming products, including limitations and mitigation steps of these conventional methods are also discussed. The current legal status of the anorectics and analogues routinely encountered in non-prescription slimming formulations is also explored. Methods All reviewed literature was extracted from Scopus, Web of Science, PubMed, and Google Scholar databases using relevant search terms, such as, ‘counterfeit drugs’, ‘weight loss drugs’, ‘weight-reducing drugs’, ‘slimming drugs’, ‘anorectic agents’, and ‘counterfeit anorexics’. Legislation related to anorectics was obtained from the portals of various government and international agencies. Results Anorectics frequently profiled in counterfeit slimming formulations are mostly amphetamine derivatives or its analogues. Five routinely reported pharmacological classes of adulterants, namely anxiolytics, diuretics, antidepressants, laxatives, and stimulants, are mainly utilised as coadjuvants in fake weigh-reducing formulations to increase bioavailability or to minimise anticipated side effects. Liquid and gas chromatography coupled with mass spectrometric detectors are predominantly used techniques for anorectic analysis due to the possibility of obtaining detailed information of adulterants. However, interference from the complex sample matrices of these fake products limits the accuracy of these methods and requires robust sample preparation methods for enhanced sensitivity and selectivity. The most common anorectics found in counterfeit slimming medicines are either completely banned or available by prescription only, in many countries. Conclusions Slimming formulations doped with anorectic cocktails to boost their weight-reducing efficacy are not uncommon. Liquid chromatography combined with mass spectrometry remains the gold standard for counterfeit drug analysis, and requires improved preconcentration methods for rapid and quantitative identification of specific chemical constituents. Extensive method development and validation, targeted at refining existing techniques while developing new ones, is expected to improve the analytical profiling of counterfeit anorectics significantly.

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