A Rodent Model for Cell Transplantation of Hepatic Progenitor Cells

2018 ◽  
pp. 211-219
Author(s):  
Sei Kakinuma ◽  
Akihide Kamiya
Keyword(s):  
Progenitor Cells ◽  
Cell Transplantation ◽  
Rodent Model ◽  
Hepatic Progenitor Cells

Differentiation of Mouse Hepatic Progenitor Cells Induced by Hepatocyte Nuclear Factor-4 and Cell Transplantation in Mice With Liver Fibrosis

2008 ◽  
Vol 86 (9) ◽  
pp. 1178-1186 ◽  
Author(s):  
Atsushi Suetsugu ◽  
Masahito Nagaki ◽  
Hitomi Aoki ◽  
Tsutomu Motohashi ◽  
Takahiro Kunisada ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Progenitor Cells ◽  
Cell Transplantation ◽  
Hepatic Progenitor Cells ◽  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
Hepatocyte Nuclear Factor 4

scholarly journals Hepatic progenitor cells from adult human livers for cell transplantation

Gut ◽  
2008 ◽  
Vol 57 (8) ◽  
pp. 1129-1138 ◽  
Author(s):  
T S Weiss ◽  
M Lichtenauer ◽  
S Kirchner ◽  
P Stock ◽  
H Aurich ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Cell Transplantation ◽  
Hepatic Progenitor Cells ◽  
Adult Human ◽  
Human Livers

scholarly journals Generation of human hepatic progenitor cells with regenerative and metabolic capacities from primary hepatocytes

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Takeshi Katsuda ◽  
Juntaro Matsuzaki ◽  
Tomoko Yamaguchi ◽  
Yasuhiro Yamada ◽  
Marta Prieto-Vila ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Cell Transplantation ◽  
Human Infant ◽  
Hepatic Progenitor Cells ◽  
Chemically Induced ◽  
Cell Source ◽  
Donor Shortage ◽  
Inducing Factors ◽  
Transplantation Therapy

Hepatocytes are regarded as the only effective cell source for cell transplantation to treat liver diseases; however, their availability is limited due to a donor shortage. Thus, a novel cell source must be developed. We recently reported that mature rodent hepatocytes can be reprogrammed into progenitor-like cells with a repopulative capacity using small molecule inhibitors. Here, we demonstrate that hepatic progenitor cells can be obtained from human infant hepatocytes using the same strategy. These cells, named human chemically induced liver progenitors (hCLiPs), had a significant repopulative capacity in injured mouse livers following transplantation. hCLiPs redifferentiated into mature hepatocytes in vitro upon treatment with hepatic maturation-inducing factors. These redifferentiated cells exhibited cytochrome P450 (CYP) enzymatic activities in response to CYP-inducing molecules and these activities were comparable with those in primary human hepatocytes. These findings will facilitate liver cell transplantation therapy and drug discovery studies.

scholarly journals Generation of human hepatic progenitor cells with regenerative and metabolic capacities from primary hepatocytes

2019 ◽  
Author(s):  
Takeshi Katsuda ◽  
Juntaro Matsuzaki ◽  
Tomoko Yamaguchi ◽  
Yasuhiro Yamada ◽  
Kazunori Hosaka ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Cell Transplantation ◽  
Human Infant ◽  
Hepatic Progenitor Cells ◽  
Chemically Induced ◽  
Cell Source ◽  
Donor Shortage ◽  
Inducing Factors ◽  
Transplantation Therapy

AbstractHepatocytes are regarded as the only effective cell source for cell transplantation to treat liver diseases; however, their availability is limited due to a donor shortage. Thus, a novel cell source must be developed. We recently reported that mature rodent hepatocytes can be reprogrammed into progenitor-like cells with a repopulative capacity using small molecule inhibitors. Here, we demonstrate that hepatic progenitor cells can be obtained from human infant hepatocytes using the same strategy. These cells, named human chemically induced liver progenitors (hCLiPs), had a significant repopulative capacity in injured mouse livers following transplantation. hCLiPs redifferentiated into mature hepatocytes in vitro upon treatment with hepatic maturation-inducing factors. These redifferentiated cells exhibited cytochrome P450 (CYP) enzymatic activities in response to CYP-inducing molecules and these activities were comparable with those in primary human hepatocytes. These findings will facilitate liver cell transplantation therapy and drug discovery studies.

Wnt signaling pathway regulates the differentiation of hepatic progenitor cells

2010 ◽  
Vol 34 (8) ◽  
pp. S41-S41
Author(s):  
Yang Bi ◽  
Yun He ◽  
Tingyu Li ◽  
Tao Feng ◽  
Tongchuan He
Keyword(s):  
Wnt Signaling ◽  
Progenitor Cells ◽  
Signaling Pathway ◽  
Wnt Signaling Pathway ◽  
Hepatic Progenitor Cells

“Blastosphere”: A new culture method for human fetal hepatic progenitor cells

2001 ◽  
Vol 120 (5) ◽  
pp. A542-A543
Author(s):  
T HIROSE ◽  
K YASUCHIKA ◽  
T FUJIKAWA ◽  
H FUJII ◽  
S OE ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Culture Method ◽  
Hepatic Progenitor Cells
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